MPG and HSD17B14

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		MPG	HSD17B14
Gene Name		N-methylpurine-DNA glycosylase	hydroxysteroid (17-beta) dehydrogenase 14
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Mitochondrial Nucleoid	Cytosol
	Molecular Function	Damaged DNA Binding Alkylbase DNA N-glycosylase Activity Protein Binding DNA-3-methyladenine Glycosylase Activity DNA-7-methylguanine Glycosylase Activity DNA-7-methyladenine Glycosylase Activity DNA-3-methylguanine Glycosylase Activity	Estradiol 17-beta-dehydrogenase Activity Protein Binding Testosterone 17-beta-dehydrogenase (NADP+) Activity
	Biological Process	DNA Repair Base-excision Repair Base-excision Repair, AP Site Formation DNA Dealkylation Involved In DNA Repair Depurination	Steroid Catabolic Process Oxidation-reduction Process
Pathways		Depurination Base Excision Repair Resolution of AP sites via the multiple-nucleotide patch replacement pathway Base-Excision Repair, AP Site Formation Removal of DNA patch containing abasic residue Resolution of AP sites via the single-nucleotide replacement pathway Base-free sugar-phosphate removal via the single-nucleotide replacement pathway Displacement of DNA glycosylase by APE1 Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Resolution of Abasic Sites (AP sites)
Drugs
Diseases
GWAS		Red blood cell traits ( 23446634)
Protein-Protein Interactions		9 interactors: APP EP300 ESR1 HSD17B14 RAD23A RAD23B RXRA TERF2IP THRB	15 interactors: CA8 CDKN2D DDIT3 LINC00152 MIR4435-1HG MPG NEK6 NUDT18 PHF1 PSMA1 SNAPC3 SNRPC SREK1IP1 TBC1D22B WDYHV1
Entrez ID		4350	51171
HPRD ID		06766	16801
Ensembl ID		ENSG00000103152	ENSG00000087076
Uniprot IDs		P29372 Q1W6H1	Q9BPX1
PDB IDs		1BNK 1EWN 1F4R 1F6O 3QI5 3UBY	1YDE
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Steroid Metabolic Process Regulation Of Branching Involved In Prostate Gland Morphogenesis Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Reproduction Response To Steroid Hormone Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Cellular Response To Steroid Hormone Stimulus Mating Behavior Reproductive Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Nitrogen Compound Metabolic Process DNA-templated Transcription, Initiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Multicellular Organismal Reproductive Process Mating Multicellular Organism Reproduction Response To Lipid Cellular Response To DNA Damage Stimulus Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Organic Cyclic Compound Cellular Response To Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Response To Hormone Regulation Of Morphogenesis Of A Branching Structure Prostate Gland Development Positive Regulation Of Viral Process Organ Morphogenesis RNA Metabolic Process Cellular Response To Organic Cyclic Compound Chromosome Organization Regulation Of Cellular Protein Metabolic Process Histone H2B Acetylation Negative Regulation Of DNA Recombination At Telomere Maternal Process Involved In Female Pregnancy Cellular Response To Lipid Epithelium Development Negative Regulation Of Cellular Metabolic Process Gene Expression Posttranscriptional Regulation Of Gene Expression	Cellular Response To DNA Damage Stimulus Deoxyribose Phosphate Catabolic Process Cellular Response To Stress Deoxyribonucleotide Catabolic Process Purine Nucleotide Catabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Deoxyribonucleotide Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Determination Of Dorsal Identity GDP Catabolic Process DGDP Catabolic Process DADP Catabolic Process Nucleotide Catabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription Involved In Anterior/posterior Axis Specification Regulation Of Cell Cycle Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Apoptotic Process Depurination Negative Regulation Of Cell Cycle Programmed Cell Death Cell Cycle Process Cell Death Death MRNA 5'-splice Site Recognition Negative Regulation Of Histone H3-K27 Methylation Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Regulation Of Cellular Protein Metabolic Process Cell Cycle Arrest Organophosphate Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway DNA Damage Checkpoint Purine Ribonucleoside Diphosphate Catabolic Process Nucleobase-containing Small Molecule Catabolic Process G1/S Transition Of Mitotic Cell Cycle DNA Dealkylation Involved In DNA Repair Autophagic Cell Death Base-excision Repair, AP Site Formation Ribonucleoside Diphosphate Catabolic Process Regulation Of Protein Metabolic Process Nucleoside Diphosphate Catabolic Process Cell Cycle Negative Regulation Of Wnt Signaling Pathway Regulation Of Proteolysis SnRNA Transcription ER Overload Response Mitotic Cell Cycle Process Response To Stress
Tagcloud ?		adherens arg1 cadherin cadherins clustered coculture coculturing coimmunoprecipitation csi desmocollin desmoglein desmoplakin desmosomal desmosomes dsc dsc1 dsc1a dsg dsg2 fibrosarcoma ht intercellular junctions lysates plakoglobin portion repeats tagged thr170
Tagcloud (Difference) ?		adherens arg1 cadherin cadherins clustered coculture coculturing coimmunoprecipitation csi desmocollin desmoglein desmoplakin desmosomal desmosomes dsc dsc1 dsc1a dsg dsg2 fibrosarcoma ht intercellular junctions lysates plakoglobin portion repeats tagged thr170
Tagcloud (Intersection) ?