MPG and HSD17B14

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid, two hybrid)

		MPG	HSD17B14
Name		N-methylpurine DNA glycosylase	hydroxysteroid 17-beta dehydrogenase 14
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Mitochondrial Nucleoid	Cytoplasm Cytosol
	Molecular Function	DNA Binding Damaged DNA Binding Catalytic Activity Alkylbase DNA N-glycosylase Activity Protein Binding Hydrolase Activity DNA N-glycosylase Activity	Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Protein Binding Oxidoreductase Activity Identical Protein Binding D-threo-aldose 1-dehydrogenase Activity
	Biological Process	DNA Repair Base-excision Repair DNA Alkylation Repair DNA Damage Response Depurination	Fucose Metabolic Process Lipid Metabolic Process Steroid Metabolic Process L-fucose Catabolic Process
Pathways		Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Displacement of DNA glycosylase by APEX1	Estrogen biosynthesis
Drugs		Cisplatin Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form	None
GWAS		Blood protein levels ( 30072576 ) Glioblastoma ( 28346443 ) Hemoglobin levels ( 26366553 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular hemoglobin concentration ( 32888494 ) Mean corpuscular volume ( 32888494 ) Red blood cell traits ( 23446634 )	Blood protein levels ( 30072576 ) Resting metabolic rate ( 28476931 )
Novel Interactors		1 novel interactors: RBFOX1	None recorded
Interacting Genes		13 interacting genes: ACKR5 APP CRK EP300 ESR1 FBXO7 HSD17B14 MLH1 RAD23A RAD23B RXRA TERF2IP THRB	24 interacting genes: AKIRIN2 BRIP1 CA8 CDKN2D CYTOR DDIT3 INCA1 MIA3 MIR4435-2HG MPG NEK6 NTAQ1 NUDT18 OTUD3 PGLYRP3 PHF1 PICK1 PIDD1 PSMA1 REL SNAPC3 SNRPC SREK1IP1 TBC1D22B
Entrez ID		4350	51171
HPRD ID		06766	16801
Ensembl ID		ENSG00000103152	ENSG00000087076
Uniprot IDs		P29372 Q1W6H1	A0A140VJH8 Q9BPX1
PDB IDs		1BNK 1EWN 1F4R 1F6O 3QI5 3UBY 7XFH 7XFJ 7XFM	1YDE 5EN4 5HS6 5ICM 5ICS 5JS6 5JSF 5L7T 5L7W 5L7Y 5O42 5O43 5O6O 5O6X 5O6Z 5O72 5O7C 6EMM 6FFB 6G4L 6GBT 6GTB 6GTU 6H0M 6HNO 6QCK 6ZDE 6ZDI 6ZR6 6ZRA 6ZT2
GO Terms Enriched among Interactors		Enzyme Binding Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Nucleic Acid Metabolic Process Transcription Coregulator Binding Transcription Coactivator Binding Nuclear Receptor Activity Regulation Of Thyroid Hormone Receptor Signaling Pathway Protein-containing Complex Damaged DNA Binding Chromatin Binding Cell Development Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Response To Yeast Transcription By RNA Polymerase II Nuclear Receptor-mediated Signaling Pathway Ubiquitin Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Localization To Chromosome Single-stranded DNA Binding Positive Regulation Of DNA-binding Transcription Factor Activity Proteasome Binding Mating Behavior Macromolecule Metabolic Process Regulation Of Metabolic Process Nuclear Steroid Receptor Activity Regulation Of Primary Metabolic Process Positive Regulation Of Intracellular Signal Transduction Retinoic Acid Receptor Signaling Pathway Negative Regulation Of MiRNA Transcription Intracellular Signal Transduction Ephrin Receptor Binding Hormone-mediated Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleus DNA Damage Response DNA-templated Transcription Reproductive Behavior Positive Regulation Of Protein Localization Regulation Of Innate Immune Response Catabolic Process Positive Regulation Of Metabolic Process Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Macromolecule Metabolic Process Polyubiquitin Modification-dependent Protein Binding Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Biosynthetic Process RNA Metabolic Process	None