MPG and ACKR5

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		MPG	ACKR5
Description		N-methylpurine DNA glycosylase	atypical chemokine receptor 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Mitochondrial Nucleoid	Plasma Membrane Membrane
	Molecular Function	DNA Binding Damaged DNA Binding Catalytic Activity Alkylbase DNA N-glycosylase Activity Protein Binding Hydrolase Activity DNA N-glycosylase Activity	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity
	Biological Process	DNA Repair Base-excision Repair DNA Alkylation Repair DNA Damage Response Depurination	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway
Pathways		Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Displacement of DNA glycosylase by APEX1
Drugs		Cisplatin Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Blood protein levels ( 30072576) Glioblastoma ( 28346443) Hemoglobin levels ( 26366553) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell traits ( 23446634)
Interacting Genes		13 interacting genes: ACKR5 APP CRK EP300 ESR1 FBXO7 HSD17B14 MLH1 RAD23A RAD23B RXRA TERF2IP THRB	10 interacting genes: ABHD12 GOSR1 HLA-C ITGA5 MPG OGFR PLPPR3 TMEM101 TMEM30A TMUB2
Entrez ID		4350	11318
HPRD ID		06766	05605
Ensembl ID		ENSG00000103152	ENSG00000166856
Uniprot IDs		P29372 Q1W6H1	O15218
PDB IDs		1BNK 1EWN 1F4R 1F6O 3QI5 3UBY 7XFH 7XFJ 7XFM
Enriched GO Terms of Interacting Partners?		Enzyme Binding Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Nucleic Acid Metabolic Process Transcription Coregulator Binding Transcription Coactivator Binding Nuclear Receptor Activity Regulation Of Thyroid Hormone Receptor Signaling Pathway Protein-containing Complex Damaged DNA Binding Chromatin Binding Cell Development Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Response To Yeast Transcription By RNA Polymerase II Nuclear Receptor-mediated Signaling Pathway Ubiquitin Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Localization To Chromosome Single-stranded DNA Binding Positive Regulation Of DNA-binding Transcription Factor Activity Proteasome Binding Mating Behavior Macromolecule Metabolic Process Regulation Of Metabolic Process Nuclear Steroid Receptor Activity Regulation Of Primary Metabolic Process Positive Regulation Of Intracellular Signal Transduction Retinoic Acid Receptor Signaling Pathway Negative Regulation Of MiRNA Transcription Intracellular Signal Transduction Ephrin Receptor Binding Hormone-mediated Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleus DNA Damage Response DNA-templated Transcription Reproductive Behavior Positive Regulation Of Protein Localization Regulation Of Innate Immune Response Catabolic Process Positive Regulation Of Metabolic Process Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Macromolecule Metabolic Process Polyubiquitin Modification-dependent Protein Binding Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Biosynthetic Process RNA Metabolic Process
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