MPG and THRB

Number of citations of the paper that reports this interaction (PubMedID 14761960)
0

Data Source:
HPRD (in vitro)

		MPG	THRB
Description		N-methylpurine DNA glycosylase	thyroid hormone receptor beta
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Mitochondrial Nucleoid	Chromatin Nucleus Nucleoplasm Nuclear Body RNA Polymerase II Transcription Regulator Complex
	Molecular Function	DNA Binding Damaged DNA Binding Catalytic Activity Alkylbase DNA N-glycosylase Activity Protein Binding Hydrolase Activity DNA N-glycosylase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Enzyme Binding Chromatin DNA Binding Sequence-specific DNA Binding Metal Ion Binding Thyroid Hormone Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA Repair Base-excision Repair DNA Alkylation Repair DNA Damage Response Depurination	Negative Regulation Of Transcription By RNA Polymerase II Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Sensory Perception Of Sound Negative Regulation Of Female Receptivity Regulation Of Heart Contraction Female Courtship Behavior Animal Organ Morphogenesis Cell Differentiation MRNA Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Retinal Cone Cell Development Retinoic Acid Receptor Signaling Pathway Type I Pneumocyte Differentiation Cellular Response To Thyroid Hormone Stimulus Retinal Cone Cell Apoptotic Process
Pathways		Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Displacement of DNA glycosylase by APEX1	Nuclear Receptor transcription pathway SUMOylation of intracellular receptors
Drugs		Cisplatin Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Liothyronine Levothyroxine Dextrothyroxine Amiodarone Liotrix [3,5-Dibromo-4-(4-Hydroxy-3-Phenethylcarbamoyl-Phenoxy)-Phenyl]-Acetic Acid KB-141 2-[4-(4-Hydroxy-3-Isopropyl-Phenoxy)-3,5-Dimethyl-Phenyl]-2h-[1,2,4]Triazine-3,5-Dione Tiratricol GC-24 Eprotirome MB07811 Sobetirome 1-(4-HEXYLPHENYL)PROP-2-EN-1-ONE Thyroid, porcine
Diseases
GWAS		Blood protein levels ( 30072576) Glioblastoma ( 28346443) Hemoglobin levels ( 26366553) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell traits ( 23446634)	Acne (severe) ( 24927181) Amyotrophic lateral sclerosis (sporadic) ( 24529757) antipsychotic drug dosage in schizophrenia or schizoaffective disorder ( 26821981) Appendicular lean mass ( 33097823) Asthma ( 29273806) Atrial fibrillation ( 30061737 29892015) Carotid intima media thickness x smoking interaction ( 32117412) Chronotype ( 30696823) Colorectal cancer ( 34062886) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Erythrocyte cadmium concentration ( 27005419) Extremely high intelligence ( 29520040) Familial squamous cell lung carcinoma ( 29924316) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Height ( 28552196) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 20139978 32888494 27863252 29403010 28017375) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean corpuscular volume ( 29403010 20139978 32888494 27863252 28017375) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Midgestational cytokine/chemokine levels (maternal genetic effect) ( 30134952) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Myopia ( 27182965) Platelet distribution width ( 32888494) PR interval ( 32439900) Red blood cell count ( 29403010 32888494 27863252) Red blood cell traits ( 23222517) Red cell distribution width ( 27863252 32888494) Refractive error ( 32231278) Relative wall thickness x antihypertensive treatment interaction ( 31407531) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure in sickle cell anemia ( 24058526) Triglyceride levels ( 32203549 32154731)
Interacting Genes		13 interacting genes: ACKR5 APP CRK EP300 ESR1 FBXO7 HSD17B14 MLH1 RAD23A RAD23B RXRA TERF2IP THRB	58 interacting genes: ACVR1 ADAT3 ANP32A ATF2 BRD8 BTG1 C1D CAMK2B CCND1 CNOT1 COPS2 CTCF ESR1 FOXO1 HDAC2 HDAC3 HMGN3 JMJD1C LRIF1 MECR MED1 MED21 MMS19 MPG NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NR2F6 NRBF2 NRIP1 NSD1 PPARGC1A PPARGC1B PRKDC PRMT1 PRMT2 PSMC3IP PSMC5 RANBP9 RARA ROBO4 RXRA RXRB RXRG SRC TBL1X TP53 TRIP10 TRIP12 TRIP13 TRIP4 TRIP6 TSG101 UBE2I ZNHIT3
Entrez ID		4350	7068
HPRD ID		06766	07521
Ensembl ID		ENSG00000103152	ENSG00000151090
Uniprot IDs		P29372 Q1W6H1	A0A024R2I8 P10828
PDB IDs		1BNK 1EWN 1F4R 1F6O 3QI5 3UBY 7XFH 7XFJ 7XFM	1BSX 1N46 1NAX 1NQ0 1NQ1 1NQ2 1NUO 1Q4X 1R6G 1XZX 1Y0X 2J4A 2NLL 2PIN 3D57 3GWS 3IMY 3JZC 4ZO1 6KKB 6KKE 6KNU 6KNV 6KNW 7WLX 7WMG 7WMH 7WMJ 7WML 7WMN 7WMO 8RQN
Enriched GO Terms of Interacting Partners?		Enzyme Binding Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Nucleic Acid Metabolic Process Transcription Coregulator Binding Transcription Coactivator Binding Nuclear Receptor Activity Regulation Of Thyroid Hormone Receptor Signaling Pathway Protein-containing Complex Damaged DNA Binding Chromatin Binding Cell Development Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Response To Yeast Transcription By RNA Polymerase II Nuclear Receptor-mediated Signaling Pathway Ubiquitin Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Localization To Chromosome Single-stranded DNA Binding Positive Regulation Of DNA-binding Transcription Factor Activity Proteasome Binding Mating Behavior Macromolecule Metabolic Process Regulation Of Metabolic Process Nuclear Steroid Receptor Activity Regulation Of Primary Metabolic Process Positive Regulation Of Intracellular Signal Transduction Retinoic Acid Receptor Signaling Pathway Negative Regulation Of MiRNA Transcription Intracellular Signal Transduction Ephrin Receptor Binding Hormone-mediated Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleus DNA Damage Response DNA-templated Transcription Reproductive Behavior Positive Regulation Of Protein Localization Regulation Of Innate Immune Response Catabolic Process Positive Regulation Of Metabolic Process Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Macromolecule Metabolic Process Polyubiquitin Modification-dependent Protein Binding Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Biosynthetic Process RNA Metabolic Process	Nuclear Thyroid Hormone Receptor Binding Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Estrogen Receptor Binding Nuclear Receptor Binding Nuclear Receptor-mediated Signaling Pathway Nuclear Retinoic Acid Receptor Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Hormone-mediated Signaling Pathway Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Enzyme Binding Chromatin Regulation Of Macromolecule Metabolic Process Transcription Coregulator Activity Transcription Coactivator Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process MRNA Transcription Chromatin Binding Negative Regulation Of Macromolecule Biosynthetic Process Transcription Corepressor Activity Negative Regulation Of Biosynthetic Process Chromatin Organization MRNA Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Rhythmic Process Transcription Repressor Complex Nuclear Retinoid X Receptor Binding
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