ASGR1 and LAMTOR5

Number of citations of the paper that reports this interaction (PubMedID 23241634)
0

Data Source:
BioGRID (two hybrid)

		ASGR1	LAMTOR5
Description		asialoglycoprotein receptor 1	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane	Cytoplasm Lysosome Lysosomal Membrane Cytosol Late Endosome Membrane Protein-containing Complex Ragulator Complex FNIP-folliculin RagC/D GAP
	Molecular Function	Asialoglycoprotein Receptor Activity Protein Binding D-mannose Binding Carbohydrate Binding Pattern Recognition Receptor Activity Identical Protein Binding Fucose Binding Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Molecular Adaptor Activity
	Biological Process	Endocytosis Receptor-mediated Endocytosis Immune Response	Regulation Of Cell Size Response To Virus Positive Regulation Of Gene Expression Viral Genome Replication Positive Regulation Of TOR Signaling Positive Regulation Of Interleukin-8 Production TORC1 Signaling Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of TORC1 Signaling
Pathways		Asparagine N-linked glycosylation	Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs		Von Willebrand factor human
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Iron status biomarkers (ferritin levels) ( 33536631) LDL cholesterol levels ( 32203549) Liver enzyme levels (alkaline phosphatase) ( 22001757 33972514) Low density lipoprotein cholesterol levels ( 32154731 33339817) Medication use (HMG CoA reductase inhibitors) ( 31015401) Serum alkaline phosphatase levels ( 29403010 31666285 33339817 33547301) Total cholesterol levels ( 33339817)
Interacting Genes		44 interacting genes: AHNAK2 AMIGO1 APH1A APP ASGR2 ATP1B4 BLCAP CERS2 CLDN7 CLEC4G CPLX4 CREB3L1 CYB5R3 DHFR ERGIC3 FAM209A FCGR1A FNDC9 GPX8 HIBADH HIVEP1 HSP90AA1 HSP90B1 IGFBP5 KIR2DL3 LAMTOR5 LEUTX LMNA MCEMP1 NEMP1 NLK PDZK1IP1 RBBP6 RNF19B SAR1A SLC10A1 SLC35H1 SNCA SPAG4 SUSD3 TG TMX2 VKORC1 VSIR	63 interacting genes: ACAA2 AKR1C2 ALB ANKRD46 ASGR1 BHMT C9 CD74 CEP126 CEP70 CFB CLIC5 DBI DNAJA3 ECT2 EEF1A1 EIF3A EIF4B GAPDH GIT1 GIT2 GPRASP1 HEBP2 HSPA9 ITGB1 KEAP1 KIF1B KMT2E LRIF1 MAF1 MCPH1 MED12L MEOX2 MKLN1 MT2A MYF6 MYH3 MYOG NCOA6 PDK1 PEG10 PPARA RABIF RBP4 SERPINA1 SFPQ SHB SKP1 SMAD4 SNX5 TAF9 TBC1D4 TCAP TCF12 TGFB1 TOP2B TP53 TRIM55 TRIM63 UTP14A YTHDC1 ZBTB16 ZNF592
Entrez ID		432	10542
HPRD ID		00151	09773
Ensembl ID		ENSG00000141505	ENSG00000134248
Uniprot IDs		P07306 Q6FGQ5	A0A8Z5A536 O43504
PDB IDs		1DV8 5JPV 5JQ1 6YAU 8TS0	3MS6 3MSH 5VOK 5X6U 5X6V 5Y38 5Y39 5Y3A 5YK3 5YK5 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3 7T3A 7T3B 7T3C 7UX2 7UXC 7UXH 8DHB
Enriched GO Terms of Interacting Partners?		Membrane Nuclear Inner Membrane	Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Animal Organ Development Negative Regulation Of Glycolytic Process Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Glucose Metabolic Process Muscle Organ Development Regulation Of Skeletal Muscle Tissue Development Regulation Of Carbohydrate Catabolic Process Negative Regulation Of ATP Metabolic Process Disordered Domain Specific Binding Cell Activation Centrosome Striated Muscle Tissue Development RNA Polymerase II Transcription Regulator Complex Regulation Of Nucleobase-containing Compound Metabolic Process Response To Muscle Activity Muscle Structure Development Muscle Tissue Morphogenesis Negative Regulation Of Growth Regulation Of MiRNA Transcription Protein Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Small Molecule Metabolic Process Leukocyte Activation Positive Regulation Of RNA Metabolic Process Muscle Tissue Development Regulation Of Purine Nucleotide Metabolic Process Striated Muscle Atrophy Regulation Of Muscle Cell Differentiation Lymphocyte Activation Lymphocyte Differentiation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of DNA-templated Transcription Hexose Metabolic Process Protein-containing Complex Binding Germ Cell Migration Regulation Of MiRNA Metabolic Process Anterior/posterior Pattern Specification Positive Regulation Of Skeletal Muscle Fiber Development Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Sarcomere Organization Regulation Of Striated Muscle Tissue Development Muscle Atrophy Heart Development Identical Protein Binding
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