ASGR1 and CERS2

Number of citations of the paper that reports this interaction (PMID 11543633)
7

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		ASGR1	CERS2
Gene Name		asialoglycoprotein receptor 1	ceramide synthase 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Integral Component Of Plasma Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Nuclear Membrane
	Molecular Function	Asialoglycoprotein Receptor Activity Protein Binding Carbohydrate Binding Protein Homodimerization Activity Metal Ion Binding	DNA Binding Protein Binding Sphingosine N-acyltransferase Activity
	Biological Process	Receptor-mediated Endocytosis Cellular Response To Extracellular Stimulus	Sphingolipid Metabolic Process Sphingolipid Biosynthetic Process Small Molecule Metabolic Process Ceramide Biosynthetic Process
Pathways			Sphingolipid metabolism Metabolism of lipids and lipoproteins Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Liver enzyme levels (alkaline phosphatase) ( 22001757)	Rhegmatogenous retinal detachment ( 23585552)
Protein-Protein Interactions		12 interactors: APP ASGR2 CERS2 CLEC4G DHFR HIVEP1 HSP90AA1 HSP90B1 NLK RBBP6 TG VKORC1	9 interactors: ASGR1 ASGR2 ATP6V0C HSP90AA1 PEX6 SLC19A2 SLC22A1 SLC39A1 TMBIM6
Entrez ID		432	29956
HPRD ID		00151	06080
Ensembl ID		ENSG00000141505	ENSG00000143418
Uniprot IDs		P07306 Q6FGQ5	Q96G23
PDB IDs		1DV8
Enriched GO Terms of Interacting Partners?		Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Cellular Metabolic Process Regulation Of Nitric-oxide Synthase Activity Endocytosis Receptor-mediated Endocytosis Regulation Of Oxidoreductase Activity Actin Rod Assembly Synaptic Growth At Neuromuscular Junction Reactive Oxygen Species Metabolic Process Vitamin Metabolic Process Collateral Sprouting In Absence Of Injury Response To Unfolded Protein Protein Import Into Mitochondrial Outer Membrane Serine Phosphorylation Of STAT3 Protein Sequestering Of Calcium Ion Collateral Sprouting Axon Midline Choice Point Recognition Serine Phosphorylation Of STAT Protein Small Molecule Metabolic Process Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Iodide Transport Axon Choice Point Recognition Vitamin K Metabolic Process Vesicle-mediated Transport	Transmembrane Transport Transport Drug Transmembrane Transport Drug Transport Intracellular Protein Transmembrane Transport Protein Transmembrane Transport Receptor-mediated Endocytosis Epinephrine Transport Response To Unfolded Protein Protein Import Into Peroxisome Matrix, Translocation Acetate Ester Transport Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Regulation Of Protein Stability Protein Import Into Mitochondrial Outer Membrane Norepinephrine Transport Protein Import Endocytosis Thiamine Transmembrane Transport Thiamine Transport Thiamine-containing Compound Metabolic Process Ion Transport Folic Acid Transport Chemical Homeostasis Dopamine Transport Cation Transmembrane Transport Chaperone-mediated Protein Complex Assembly Protein Import Into Peroxisome Matrix Pyrimidine-containing Compound Transmembrane Transport Quaternary Ammonium Group Transport Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Establishment Of Protein Localization To Organelle Protein Refolding Vitamin Transmembrane Transport Cation Transport Zinc Ion Transmembrane Transport Cellular Metal Ion Homeostasis Monoamine Transport Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Response To Stimulus Protein Targeting Ion Transmembrane Transport Nitric Oxide Metabolic Process Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Cation Homeostasis Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Cellular Response To Heat Cellular Ion Homeostasis Reactive Nitrogen Species Metabolic Process Posttranscriptional Regulation Of Gene Expression
Tagcloud ?			17beta ceramide ceramides cers4 cers5 cers6 clarify constructs dimerization erbeta estradiol fos fulvestrant fumonisin gper1 investigating lengths luc luciferase mcf pathophysiological plasmids posttranscriptional processess promoters sphingolipid synthases utr
Tagcloud (Difference) ?			17beta ceramide ceramides cers4 cers5 cers6 clarify constructs dimerization erbeta estradiol fos fulvestrant fumonisin gper1 investigating lengths luc luciferase mcf pathophysiological plasmids posttranscriptional processess promoters sphingolipid synthases utr
Tagcloud (Intersection) ?