ASGR1 and CPLX4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ASGR1	CPLX4
Description		asialoglycoprotein receptor 1	complexin 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane	Plasma Membrane Membrane SNARE Complex Terminal Bouton Synapse
	Molecular Function	Asialoglycoprotein Receptor Activity Protein Binding D-mannose Binding Carbohydrate Binding Pattern Recognition Receptor Activity Identical Protein Binding Fucose Binding Metal Ion Binding	SNARE Binding Protein Binding Syntaxin Binding
	Biological Process	Endocytosis Receptor-mediated Endocytosis Immune Response	Neurotransmitter Transport Exocytosis Visual Perception Synaptic Vesicle Exocytosis Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Neurotransmitter Secretion Modulation Of Chemical Synaptic Transmission
Pathways		Asparagine N-linked glycosylation
Drugs		Von Willebrand factor human
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Iron status biomarkers (ferritin levels) ( 33536631) LDL cholesterol levels ( 32203549) Liver enzyme levels (alkaline phosphatase) ( 22001757 33972514) Low density lipoprotein cholesterol levels ( 32154731 33339817) Medication use (HMG CoA reductase inhibitors) ( 31015401) Serum alkaline phosphatase levels ( 29403010 31666285 33339817 33547301) Total cholesterol levels ( 33339817)	Cardiac troponin-I levels ( 31014085) Chronotype ( 27494321) Macular thickness ( 30535121) Morning vs. evening chronotype ( 27494321)
Interacting Genes		44 interacting genes: AHNAK2 AMIGO1 APH1A APP ASGR2 ATP1B4 BLCAP CERS2 CLDN7 CLEC4G CPLX4 CREB3L1 CYB5R3 DHFR ERGIC3 FAM209A FCGR1A FNDC9 GPX8 HIBADH HIVEP1 HSP90AA1 HSP90B1 IGFBP5 KIR2DL3 LAMTOR5 LEUTX LMNA MCEMP1 NEMP1 NLK PDZK1IP1 RBBP6 RNF19B SAR1A SLC10A1 SLC35H1 SNCA SPAG4 SUSD3 TG TMX2 VKORC1 VSIR	100 interacting genes: ADIPOQ AGTRAP AIG1 AOC3 APOD AQP1 AQP9 ASGR1 ATP6V0C BMP10 BNIP2 C14orf180 C1GALT1 C3orf52 C5 CACNG1 CCL4L2 CD81 CDIPT CDS2 CLDND2 CLEC4G CLN6 CMTM5 CNIH1 CTSA CTXN3 CYB5B CYBC1 CYP4F2 DEFB127 EMD GAD2 GIMAP1 GRM2 HACD1 HHATL HMOX1 IGFBP5 INSIG2 LHFPL5 LPAR3 MAL MALL MAN2B2 MGAM NINJ2 NRM ORMDL1 PGAP2 PLN PLP2 PLPP4 PNLIPRP1 PTPN9 RTP2 SEC22B SELENOK SFTPC SLC30A2 SLC30A8 SLC35A1 SLC35A4 SLC35B4 SLC38A7 SLC39A9 SMCO4 SMIM1 SNCA STX3 STX8 SYNJ2BP TF TMEM107 TMEM120B TMEM128 TMEM14A TMEM14B TMEM19 TMEM201 TMEM203 TMEM218 TMEM229B TMEM243 TMEM254 TMEM267 TMEM42 TMEM60 TMEM79 TMEM86A TMEM97 TRAF3IP3 TSPO2 UBIAD1 VAMP4 VAMP5 VKORC1 WFDC2 YIPF6 ZFPL1
Entrez ID		432	339302
HPRD ID		00151	13091
Ensembl ID		ENSG00000141505	ENSG00000166569
Uniprot IDs		P07306 Q6FGQ5	Q7Z7G2
PDB IDs		1DV8 5JPV 5JQ1 6YAU 8TS0
Enriched GO Terms of Interacting Partners?		Membrane Nuclear Inner Membrane	Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Protein Binding Chemical Homeostasis Golgi Membrane Cholesterol Binding Intracellular Chemical Homeostasis Monoatomic Cation Homeostasis Pyrimidine Nucleotide-sugar Transmembrane Transport Monoatomic Ion Homeostasis Nucleotide-sugar Transmembrane Transport Homeostatic Process Vitamin K Metabolic Process Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Golgi Apparatus Spindle Pole Centrosome Cellular Homeostasis Hydrogen Peroxide Channel Activity Negative Regulation Of Chaperone-mediated Autophagy Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Inorganic Ion Homeostasis Hydrogen Peroxide Transmembrane Transport Nuclear Inner Membrane Respiratory Burst After Phagocytosis Regulation Of Chemokine Production Negative Regulation Of Lipoprotein Metabolic Process Cellular Response To CAMP Zinc:proton Antiporter Activity Zinc Ion Transmembrane Transporter Activity Pyrimidine Nucleotide-sugar Transmembrane Transporter Activity Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Zinc Ion Transmembrane Transport Menaquinone Metabolic Process Lysosome Zinc Ion Transport Glycerol Transmembrane Transport Multicellular Organismal-level Chemical Homeostasis Intracellular Zinc Ion Homeostasis Positive Regulation Of Chemokine Production Cortical Endoplasmic Reticulum Regulation Of Chaperone-mediated Autophagy Endomembrane System Long-chain Fatty Acid Catabolic Process Regulation Of Cellular Localization
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