ASGR1 and HSP90B1

Number of citations of the paper that reports this interaction (PMID 12167617)
6

Data Source:
HPRD (in vivo)

		ASGR1	HSP90B1
Gene Name		asialoglycoprotein receptor 1	heat shock protein 90kDa beta (Grp94), member 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Integral Component Of Plasma Membrane	Extracellular Region Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Focal Adhesion Membrane Midbody Extracellular Matrix Melanosome Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Endocytic Vesicle Lumen
	Molecular Function	Asialoglycoprotein Receptor Activity Protein Binding Carbohydrate Binding Protein Homodimerization Activity Metal Ion Binding	RNA Binding Calcium Ion Binding Protein Binding ATP Binding Protein Phosphatase Binding Virion Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding
	Biological Process	Receptor-mediated Endocytosis Cellular Response To Extracellular Stimulus	Response To Hypoxia Toll-like Receptor Signaling Pathway Protein Folding Receptor-mediated Endocytosis Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Protein Transport ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Actin Rod Assembly Negative Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity Cellular Protein Metabolic Process Innate Immune Response Sequestering Of Calcium Ion Cellular Response To ATP
Pathways			Toll-Like Receptors Cascades Trafficking and processing of endosomal TLR Scavenging by Class A Receptors ATF6-alpha activates chaperones ATF6-alpha activates chaperone genes Unfolded Protein Response (UPR) Innate Immune System
Drugs			Rifabutin 2-Chlorodideoxyadenosine 1-Methoxy-2-(2-Methoxyethoxy)Ethane Adenosine-5\'-Diphosphate N-Ethyl-5\'-Carboxamido Adenosine Radicicol METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE
Diseases
GWAS		Liver enzyme levels (alkaline phosphatase) ( 22001757)	Coronary heart disease ( 21626137)
Protein-Protein Interactions		12 interactors: APP ASGR2 CERS2 CLEC4G DHFR HIVEP1 HSP90AA1 HSP90B1 NLK RBBP6 TG VKORC1	21 interactors: APOB ASGR1 BIRC2 CCT2 CSNK2A1 CSNK2A2 EGFR ERBB2 FANCC HSPA9 LRP1 MAPK6 MDM2 MTTP NKX3-1 POLR2E TG TLR1 TLR2 TLR4 TXNDC11
Entrez ID		432	7184
HPRD ID		00151	01860
Ensembl ID		ENSG00000141505	ENSG00000166598
Uniprot IDs		P07306 Q6FGQ5	B4DHT9 P14625
PDB IDs		1DV8
Enriched GO Terms of Interacting Partners?		Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Cellular Metabolic Process Regulation Of Nitric-oxide Synthase Activity Endocytosis Receptor-mediated Endocytosis Regulation Of Oxidoreductase Activity Actin Rod Assembly Synaptic Growth At Neuromuscular Junction Reactive Oxygen Species Metabolic Process Vitamin Metabolic Process Collateral Sprouting In Absence Of Injury Response To Unfolded Protein Protein Import Into Mitochondrial Outer Membrane Serine Phosphorylation Of STAT3 Protein Sequestering Of Calcium Ion Collateral Sprouting Axon Midline Choice Point Recognition Serine Phosphorylation Of STAT Protein Small Molecule Metabolic Process Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Iodide Transport Axon Choice Point Recognition Vitamin K Metabolic Process Vesicle-mediated Transport	Cellular Response To Stimulus Response To External Stimulus Immune Response-regulating Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Detection Of Molecule Of Bacterial Origin Response To Stimulus Innate Immune Response Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Lipoprotein Transport Cellular Response To Triacyl Bacterial Lipopeptide Detection Of Triacyl Bacterial Lipopeptide Negative Regulation Of Mitotic Cell Cycle Cellular Response To Lipid Detection Of Biotic Stimulus Macrophage Activation Response To Abiotic Stimulus Toll-like Receptor Signaling Pathway Positive Regulation Of Nucleocytoplasmic Transport Immune System Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Immune Response Cell Communication Response To Stress Positive Regulation Of Nitric Oxide Biosynthetic Process Activation Of Innate Immune Response Cellular Metabolic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Immune Response Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Protein Transport Defense Response Cellular Protein Metabolic Process Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Transport Detection Of Bacterial Lipoprotein Signal Transduction Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Innate Immune Response Regulation Of Establishment Of Protein Localization Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Cell Proliferation Regulation Of Mitotic Cell Cycle Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Interleukin-6 Production Positive Regulation Of Cytokine Biosynthetic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Tagcloud ?			adaptive attenuates attractive carcinogen ceramides chaperone compensatory controversial cre dena diethyl expansion gp96 grp94 hccs hepatocyte hepatocytes hyperplasia maintains nitrosoamine oncogenesis paralog perturbs pharmacologically predisposes probed recombinase steatotic vital
Tagcloud (Difference) ?			adaptive attenuates attractive carcinogen ceramides chaperone compensatory controversial cre dena diethyl expansion gp96 grp94 hccs hepatocyte hepatocytes hyperplasia maintains nitrosoamine oncogenesis paralog perturbs pharmacologically predisposes probed recombinase steatotic vital
Tagcloud (Intersection) ?