MMP25 and CLU

Number of citations of the paper that reports this interaction (PMID 12860995)
5

Data Source:
HPRD (in vivo, in vitro)

		MMP25	CLU
Gene Name		matrix metallopeptidase 25	clusterin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Plasma Membrane Membrane Integral Component Of Membrane Anchored Component Of Membrane	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Matrix Platelet Alpha Granule Lumen Mitochondrial Membrane Spherical High-density Lipoprotein Particle Chromaffin Granule Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Blood Microparticle Neurofibrillary Tangle Apical Dendrite
	Molecular Function	Metalloendopeptidase Activity Calcium Ion Binding Zinc Ion Binding	Protein Binding ATPase Activity Ubiquitin Protein Ligase Binding Misfolded Protein Binding
	Biological Process	Proteolysis Inflammatory Response Hard Palate Development	Cell Morphogenesis Microglial Cell Activation Release Of Cytochrome C From Mitochondria Platelet Degranulation Lipid Metabolic Process Complement Activation Complement Activation, Classical Pathway Blood Coagulation Response To Virus Protein Import Platelet Activation Central Nervous System Myelin Maintenance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Homooligomerization Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Apoptotic Process Reverse Cholesterol Transport Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Chaperone-mediated Protein Complex Assembly Response To Misfolded Protein Chaperone-mediated Protein Folding Microglial Cell Proliferation Intrinsic Apoptotic Signaling Pathway Regulation Of Beta-amyloid Clearance Regulation Of Neuron Death Positive Regulation Of Neuron Death Positive Regulation Of Beta-amyloid Formation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Beta-amyloid Formation Regulation Of Neuronal Signal Transduction Positive Regulation Of Tau-protein Kinase Activity Positive Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Activation of Matrix Metalloproteinases Degradation of the extracellular matrix	Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS			Alzheimer's disease ( 19734902 19734903 21627779) Alzheimer's disease (late onset) ( 21460841) Panic disorder ( 19165232)
Protein-Protein Interactions		2 interactors: CLU MMP2	44 interactors: APP BAG6 C7 C8B C9 CBY1 CD209 CLUAP1 CYP2E1 DISC1 ELN FOS GRB2 HSPD1 IL24 KATNA1 KEAP1 KLF11 KNSTRN LEP LEPR LIG4 LRP2 LRP8 LYZ MAPK9 MDM2 MMP25 PAXIP1 POLR1C PON1 PRNP RBBP8 RPL23 SYVN1 TGFBR1 TGFBR2 TNIK TSC22D4 TTR VHL VLDLR XRCC6 ZWINT
Entrez ID		64386	1191
HPRD ID		07090	01706
Ensembl ID		ENSG00000008516	ENSG00000120885
Uniprot IDs		Q9NPA2	P10909
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Tau-protein Kinase Activity Microglial Cell Proliferation Regulation Of Neuronal Signal Transduction Positive Regulation Of Neurofibrillary Tangle Assembly Central Nervous System Myelin Maintenance Regulation Of Tau-protein Kinase Activity Negative Regulation Of Protein Homooligomerization Positive Regulation Of Inclusion Body Assembly Regulation Of Beta-amyloid Clearance Positive Regulation Of Beta-amyloid Formation Intramembranous Ossification Negative Regulation Of Protein Oligomerization Positive Regulation Of Immune Response Bone Trabecula Formation Negative Regulation Of Beta-amyloid Formation Blood Vessel Maturation Chaperone-mediated Protein Complex Assembly Microglial Cell Activation Negative Regulation Of Amyloid Precursor Protein Catabolic Process Glial Cell Proliferation Response To Misfolded Protein Regulation Of Immune Response Regulation Of Beta-amyloid Formation Bone Trabecula Morphogenesis Positive Regulation Of Immune System Process Regulation Of Inclusion Body Assembly Reverse Cholesterol Transport Regulation Of Amyloid Precursor Protein Catabolic Process Central Nervous System Myelination Cell Morphogenesis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Protein Oligomerization Macrophage Activation Release Of Cytochrome C From Mitochondria Myelin Maintenance Face Morphogenesis Regulation Of Immune System Process Endodermal Cell Differentiation Head Morphogenesis Positive Regulation Of Nitric Oxide Biosynthetic Process Oligodendrocyte Development Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Trabecula Morphogenesis Face Development Endoderm Formation Positive Regulation Of Tumor Necrosis Factor Production Body Morphogenesis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Cellular Response To Amino Acid Stimulus	Response To Stress Response To Stimulus Regulation Of Protein Metabolic Process Response To Radiation Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Anatomical Structure Development Developmental Process Immune System Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Immune Response Regulation Of Immune System Process Regulation Of Cell Differentiation Defense Response Multicellular Organismal Development Cytolysis Cellular Response To Stimulus Innate Immune Response Nervous System Development Regulation Of Metabolic Process Positive Regulation Of Protein Modification Process Central Nervous System Development Positive Regulation Of Proteolysis Complement Activation, Alternative Pathway Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Response To Light Stimulus Regulation Of Cell Development Response To External Stimulus Positive Regulation Of Cell Differentiation Regulation Of Phosphorylation Generation Of Neurons Alcohol Metabolic Process Positive Regulation Of Metabolic Process System Development Positive Regulation Of Immune System Process Negative Regulation Of Apoptotic Process Response To Organic Substance Negative Regulation Of Programmed Cell Death Positive Regulation Of Protein Phosphorylation Neurogenesis Steroid Metabolic Process Regulation Of Apoptotic Process Apoptotic Process Regulation Of Protein Processing Negative Regulation Of Cell Death Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation
Tagcloud ?		19k adamts4 bmp5 col4a1 compugen foxp1 fractured fst gadd45b gsn ibsp inhba itgb2 lowess mepe morphogenic nherf1 oa op osteocytes pde4a print ptk9 subchondral tgfb1 twist1 vcam1 wingless wnt5b	allometric allometry amphotericin bolus cmin contributions cpeak disposition hplc humans insignificant inspite interspecies mrt parameter perform pharmacokinetic pharmacokinetics predictions preliminary rabbits rationalized scaling t0 triexponential vdarea vss vuss
Tagcloud (Difference) ?		19k adamts4 bmp5 col4a1 compugen foxp1 fractured fst gadd45b gsn ibsp inhba itgb2 lowess mepe morphogenic nherf1 oa op osteocytes pde4a print ptk9 subchondral tgfb1 twist1 vcam1 wingless wnt5b	allometric allometry amphotericin bolus cmin contributions cpeak disposition hplc humans insignificant inspite interspecies mrt parameter perform pharmacokinetic pharmacokinetics predictions preliminary rabbits rationalized scaling t0 triexponential vdarea vss vuss
Tagcloud (Intersection) ?