FOXO4 and AKT2

Number of citations of the paper that reports this interaction (PubMedID 11313479)
77

Data Source:
HPRD (in vivo)

		FOXO4	AKT2
Description		forkhead box O4	AKT serine/threonine kinase 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Cell Cortex Membrane Ruffle Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleic Acid Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Enzyme Binding Identical Protein Binding Sequence-specific DNA Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity Molecular Function Activator Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Oxidative Stress Mitotic G2 DNA Damage Checkpoint Signaling Muscle Organ Development Negative Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Angiogenesis Cell Differentiation Response To Nutrient Levels Cellular Response To Oxidative Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Stem Cell Differentiation Negative Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of G0 To G1 Transition Protein K48-linked Ubiquitination Response To Water-immersion Restraint Stress	Glycogen Metabolic Process Glycogen Biosynthetic Process Glucose Metabolic Process Regulation Of Translation Apoptotic Process Signal Transduction Insulin Receptor Signaling Pathway Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Positive Regulation Of Glucose Metabolic Process Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Fatty Acid Beta-oxidation Peripheral Nervous System Myelin Maintenance Cellular Response To Insulin Stimulus Intracellular Signal Transduction Protein Modification Process Negative Regulation Of Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Fat Cell Differentiation Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of D-glucose Import Protein Stabilization Regulation Of Cell Cycle Mammary Gland Epithelial Cell Differentiation Cellular Response To High Light Intensity Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Retinal Rod Cell Apoptotic Process Positive Regulation Of Cap-dependent Translational Initiation Negative Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Cell Motility
Pathways		AKT phosphorylates targets in the nucleus Constitutive Signaling by AKT1 E17K in Cancer Ub-specific processing proteases Regulation of localization of FOXO transcription factors FOXO-mediated transcription of cell death genes FOXO-mediated transcription of cell death genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Regulation of FOXO transcriptional activity by acetylation FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes Cardiogenesis	Activation of BAD and translocation to mitochondria PIP3 activates AKT signaling PIP3 activates AKT signaling Downregulation of ERBB2:ERBB3 signaling Translocation of SLC2A4 (GLUT4) to the plasma membrane Activation of AKT2 PDE3B signalling Inhibition of TSC complex formation by PKB AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the nucleus Negative regulation of the PI3K/AKT network AKT-mediated inactivation of FOXO1A Deactivation of the beta-catenin transactivating complex CD28 dependent PI3K/Akt signaling Co-inhibition by CTLA4 G beta:gamma signalling through PI3Kgamma VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry RAB GEFs exchange GTP for GDP on RABs RUNX2 regulates genes involved in cell migration Regulation of PTEN stability and activity FLT3 Signaling Regulation of localization of FOXO transcription factors Estrogen-dependent nuclear events downstream of ESR-membrane signaling KEAP1-NFE2L2 pathway SARS-CoV-2 targets host intracellular signalling and regulatory pathways Regulation of MITF-M-dependent genes involved in pigmentation
Drugs			N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
Diseases			Ovarian cancer Familial partial lipodystrophy (FPL), including the following four diseases: Kobberling-type lipodystrophy (FPLD1); Dunnigan-type lipodystrophy (FPLD2); Dunnigan-like lipodystrophy (FPLD3); AKT2 associated lipodystrophy
GWAS			Birth weight ( 31043758) Cerebrospinal fluid t-tau:AB1-42 ratio ( 26252872) Cerebrospinal T-tau levels ( 26252872) Diastolic blood pressure ( 28739976) Lean body mass ( 28552196) Lymphocyte count ( 32888494)
Interacting Genes		15 interacting genes: AKT1 AKT2 CREBBP CTNNB1 ESR1 FOXG1 NLK PIN1 REL SFN SMAD3 SMAD4 TP53 XPO1 YWHAZ	43 interacting genes: ABCG8 AKT1 AKT1S1 APOA1 APOB APP APPL1 BLVRA CCL14 CDKN1A CHUK CLIP3 ESR1 FOXO4 FSHR GSK3B H3C1 HSP90AA1 MEOX2 MTCP1 NAMPT PDPK1 PICK1 PIP5K1C PLEKHO1 PNPLA3 POFUT1 POLR1B PRKDC RAB3D REL SH3RF1 SLC2A4 SORBS2 SORBS3 SPRR2A STEAP4 TCL1A TCL1B TMED2 TRIB3 TSC2 XIAP
Entrez ID		4303	208
HPRD ID		02070	01262
Ensembl ID		ENSG00000184481	ENSG00000105221
Uniprot IDs		P98177	B4DG79 P31751
PDB IDs		1E17 3L2C	1GZK 1GZN 1GZO 1MRV 1MRY 1O6K 1O6L 1P6S 2JDO 2JDR 2UW9 2X39 2XH5 3D0E 3E87 3E88 3E8D 8Q61 9C1W
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette Intracellular Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Protein Stability Negative Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Protein Stabilization Transcription Coactivator Binding Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Nucleoplasm Negative Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction DNA-binding Transcription Factor Binding Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Phosphoserine Residue Binding Cellular Response To Oxygen-containing Compound Negative Regulation Of Protein Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Localization Regulation Of Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Cell Population Proliferation Regulation Of Cell Cycle Gastrulation Transcription Corepressor Binding Negative Regulation Of Signaling Negative Regulation Of Cell Communication Nucleus Regulation Of Protein Metabolic Process Response To Decreased Oxygen Levels Positive Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Localization To Nucleus Regulation Of Signaling	Intracellular Signal Transduction Signal Transduction Regulation Of Intracellular Signal Transduction Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Response To Hormone Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Nitric-oxide Synthase Regulator Activity Intracellular Signaling Cassette Regulation Of Innate Immune Response Cytosol Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Hormone Stimulus Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Toll-like Receptor Signaling Pathway Response To Insulin Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Chemical Homeostasis Low-density Lipoprotein Particle Regulation Of Vesicle-mediated Transport Cellular Response To Oxygen-containing Compound Cellular Response To Amyloid-beta Homeostatic Process Response To Peptide Hormone Endocytic Vesicle Lumen Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Catabolic Process Protein Kinase Binding Regulation Of Nitric Oxide Biosynthetic Process Very-low-density Lipoprotein Particle Response To Amyloid-beta Regulation Of Immune System Process Response To Stress Positive Regulation Of Signal Transduction Regulation Of Nitric Oxide Metabolic Process Response To Nutrient Levels Regulation Of Protein Modification Process Protein Serine/threonine Kinase Binding Cholesterol Transfer Activity Regulation Of Defense Response
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