FOXO4 and FOXG1

Number of citations of the paper that reports this interaction (PubMedID 15084259)
0

Data Source:
HPRD (in vivo)

		FOXO4	FOXG1
Description		forkhead box O4	forkhead box G1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck	Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleic Acid Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Enzyme Binding Identical Protein Binding Sequence-specific DNA Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Oxidative Stress Mitotic G2 DNA Damage Checkpoint Signaling Muscle Organ Development Negative Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Angiogenesis Cell Differentiation Response To Nutrient Levels Cellular Response To Oxidative Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Stem Cell Differentiation Negative Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of G0 To G1 Transition Protein K48-linked Ubiquitination Response To Water-immersion Restraint Stress	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuroblast Proliferation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle Neuroblast Proliferation Brain Development Dorsal/ventral Pattern Formation Regulation Of Gene Expression Axon Midline Choice Point Recognition Pyramidal Neuron Migration To Cerebral Cortex Central Nervous System Neuron Differentiation Central Nervous System Neuron Development Cerebral Cortex Development Neurogenesis Forebrain Development Inner Ear Morphogenesis Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Neuron Fate Determination Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Cycle Regulation Of Neural Precursor Cell Proliferation
Pathways		AKT phosphorylates targets in the nucleus Constitutive Signaling by AKT1 E17K in Cancer Ub-specific processing proteases Regulation of localization of FOXO transcription factors FOXO-mediated transcription of cell death genes FOXO-mediated transcription of cell death genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Regulation of FOXO transcriptional activity by acetylation FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes Cardiogenesis	Regulation of MECP2 expression and activity FOXO-mediated transcription of cell cycle genes
Drugs
Diseases			Rett syndrome
GWAS			Daytime nap ( 33568662) Longevity ( 20834067) Manganese levels ( 26025379) Metabolite levels ( 23823483) Number of sexual partners ( 30643258) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Resting oxygen saturation in chronic osbtructive pulmonary disease (pulse oxymetry) ( 24825563) Smoking status (ever vs never smokers) ( 30643258) Takayasu arteritis ( 25604533)
Interacting Genes		15 interacting genes: AKT1 AKT2 CREBBP CTNNB1 ESR1 FOXG1 NLK PIN1 REL SFN SMAD3 SMAD4 TP53 XPO1 YWHAZ	19 interacting genes: APOE AR EEF1G FOXH1 FOXO1 FOXO3 FOXO4 GDF9 HDAC1 HES1 KDM5B SMAD1 SMAD2 SMAD3 SMAD4 SRF TLE1 TLE3 TLE6
Entrez ID		4303	2290
HPRD ID		02070	01283
Ensembl ID		ENSG00000184481	ENSG00000176165
Uniprot IDs		P98177	P55316
PDB IDs		1E17 3L2C	7CBY
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette Intracellular Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Protein Stability Negative Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Protein Stabilization Transcription Coactivator Binding Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Nucleoplasm Negative Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction DNA-binding Transcription Factor Binding Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Phosphoserine Residue Binding Cellular Response To Oxygen-containing Compound Negative Regulation Of Protein Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Localization Regulation Of Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Cell Population Proliferation Regulation Of Cell Cycle Gastrulation Transcription Corepressor Binding Negative Regulation Of Signaling Negative Regulation Of Cell Communication Nucleus Regulation Of Protein Metabolic Process Response To Decreased Oxygen Levels Positive Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Localization To Nucleus Regulation Of Signaling	Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription Regulator Complex Regulation Of Canonical Wnt Signaling Pathway Chromatin Negative Regulation Of RNA Metabolic Process Negative Regulation Of Wnt Signaling Pathway Anatomical Structure Morphogenesis DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific DNA Binding Regulation Of Wnt Signaling Pathway Positive Regulation Of MiRNA Transcription Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process SMAD Protein Complex Animal Organ Morphogenesis Positive Regulation Of MiRNA Metabolic Process Heteromeric SMAD Protein Complex Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of MiRNA Transcription Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MiRNA Metabolic Process DNA-binding Transcription Factor Activity Co-SMAD Binding Regulation Of Nucleobase-containing Compound Metabolic Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Growth Factor Regulation Of Cell Population Proliferation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Activin Responsive Factor Complex Positive Regulation Of Developmental Process Positive Regulation Of Biosynthetic Process I-SMAD Binding Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
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