FOXO4 and XPO1

Number of citations of the paper that reports this interaction (PubMedID 11313479)
77

Data Source:
HPRD (in vivo)

		FOXO4	XPO1
Description		forkhead box O4	exportin 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck	Kinetochore Nucleus Nuclear Envelope Annulate Lamellae Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Membrane Nuclear Membrane Protein-containing Complex Ribonucleoprotein Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleic Acid Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Enzyme Binding Identical Protein Binding Sequence-specific DNA Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	RNA Binding Nuclear Export Signal Receptor Activity Protein Binding Protein Domain Specific Binding Small GTPase Binding DNA-binding Transcription Factor Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Oxidative Stress Mitotic G2 DNA Damage Checkpoint Signaling Muscle Organ Development Negative Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Angiogenesis Cell Differentiation Response To Nutrient Levels Cellular Response To Oxidative Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Stem Cell Differentiation Negative Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of G0 To G1 Transition Protein K48-linked Ubiquitination Response To Water-immersion Restraint Stress	Ribosomal Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Negative Regulation Of Transcription By RNA Polymerase II MRNA Export From Nucleus Protein Export From Nucleus Intracellular Protein Transport Nucleocytoplasmic Transport Response To Xenobiotic Stimulus Regulation Of Centrosome Duplication Protein Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus Regulation Of Protein Catabolic Process Ribosome Biogenesis Regulation Of Protein Export From Nucleus MRNA Transport Cellular Response To Triglyceride Cellular Response To Salt
Pathways		AKT phosphorylates targets in the nucleus Constitutive Signaling by AKT1 E17K in Cancer Ub-specific processing proteases Regulation of localization of FOXO transcription factors FOXO-mediated transcription of cell death genes FOXO-mediated transcription of cell death genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Regulation of FOXO transcriptional activity by acetylation FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes Cardiogenesis	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Rev-mediated nuclear export of HIV RNA NEP/NS2 Interacts with the Cellular Export Machinery Downregulation of TGF-beta receptor signaling Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deactivation of the beta-catenin transactivating complex HuR (ELAVL1) binds and stabilizes mRNA RHO GTPases Activate Formins MAPK6/MAPK4 signaling Mitotic Prometaphase Cyclin A/B1/B2 associated events during G2/M transition Estrogen-dependent nuclear events downstream of ESR-membrane signaling EML4 and NUDC in mitotic spindle formation Heme signaling NPAS4 regulates expression of target genes Maturation of hRSV A proteins Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs			Selinexor
Diseases
GWAS			Atrial fibrillation ( 29892015) Eosinophil count ( 27863252 32888494) Erectile dysfunction ( 30583798) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 28714469) Urinary sodium excretion ( 31409800) White blood cell count ( 32888494)
Interacting Genes		15 interacting genes: AKT1 AKT2 CREBBP CTNNB1 ESR1 FOXG1 NLK PIN1 REL SFN SMAD3 SMAD4 TP53 XPO1 YWHAZ	86 interacting genes: ABL1 ADAR AGFG1 AHR ANP32A ANP32B APC ATF2 BECN1 BIRC5 BRCA2 CCND1 CDC25A CDC42 CDCA4 CDK1 CDKN1B CEBPA CHEK1 CHORDC1 CIITA CRK DDX3X DESI1 DR1 E2F4 E2F5 EIF4E EIF5A ERF FBXO7 FILNC1 FOXO4 HDAC3 HNF4A HSPA9 HSPB1 IRF5 KIF17 LINC01554 LRPPRC MAPK6 NF2 NMD3 NOSIP NPM1 NUCB1 NUCB2 NUP153 NUP214 NUP50 NUP62 NXF3 NXT1 OGT ORC1 PHAX PHB1 PKIA RAD51 RAN RANBP2 RANBP3 RCC1 RCN2 RGS14 RIC8A RPS6KB1 SERPINB1 SERTAD2 SIRT2 SMAD1 SMARCB1 SMURF1 SMURF2 SNUPN SOX2 STAT1 STRADA SUMO2 TERF2IP TERT TOP2A TOP2B TP53 TP73
Entrez ID		4303	7514
HPRD ID		02070	03975
Ensembl ID		ENSG00000184481	ENSG00000082898
Uniprot IDs		P98177	A0A7I2V2Y6 A0A7I2V461 A0A7I2V6B9 B3KWD0 O14980
PDB IDs		1E17 3L2C	1W9C 2L1L 3GB8 4BSM 4BSN 5DIS 6TVO 7B51 9B62
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette Intracellular Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Protein Stability Negative Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Protein Stabilization Transcription Coactivator Binding Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Nucleoplasm Negative Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction DNA-binding Transcription Factor Binding Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Phosphoserine Residue Binding Cellular Response To Oxygen-containing Compound Negative Regulation Of Protein Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Localization Regulation Of Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Cell Population Proliferation Regulation Of Cell Cycle Gastrulation Transcription Corepressor Binding Negative Regulation Of Signaling Negative Regulation Of Cell Communication Nucleus Regulation Of Protein Metabolic Process Response To Decreased Oxygen Levels Positive Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Localization To Nucleus Regulation Of Signaling	Nuclear Transport Nucleocytoplasmic Transport Nuclear Export Nucleoplasm Nucleus Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Cytoplasm Intracellular Transport Protein Export From Nucleus Regulation Of Primary Metabolic Process RNA Transport Establishment Of Localization In Cell Protein Import Into Nucleus Import Into Nucleus Cellular Localization Intracellular Protein Transport Protein-containing Complex Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Cycle Nuclear Pore Establishment Of Protein Localization To Organelle Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Transport Positive Regulation Of Mitotic Cell Cycle Intracellular Signal Transduction Protein Localization To Nucleus Cytosol Positive Regulation Of Metabolic Process RNA Export From Nucleus Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Positive Regulation Of RNA Metabolic Process Chromatin Binding Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Protein Localization To Organelle Negative Regulation Of Mitotic Cell Cycle DNA Binding MRNA Transport Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of DNA-templated Transcription
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