MAP3K11 and CHUK

Number of citations of the paper that reports this interaction (PMID 10713178)
16

Data Source:
BioGRID (enzymatic study)
HPRD (in vivo)

		MAP3K11	CHUK
Gene Name		mitogen-activated protein kinase kinase kinase 11	conserved helix-loop-helix ubiquitous kinase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Centrosome Microtubule Membrane	Nucleoplasm Cytoplasm Cytosol IkappaB Kinase Complex Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Identical Protein Binding Protein Homodimerization Activity Rac GTPase Binding	Protein Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity Protein Homodimerization Activity Protein Heterodimerization Activity Scaffold Protein Binding
	Biological Process	Activation Of MAPK Activity Protein Phosphorylation Microtubule-based Process JNK Cascade Activation Of JNKK Activity Activation Of JUN Kinase Activity Cell Death Cell Proliferation Peptidyl-tyrosine Phosphorylation Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of JNK Cascade Protein Autophosphorylation	Morphogenesis Of An Epithelial Sheet Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Skeletal Muscle Contraction Protein Phosphorylation Inflammatory Response Immune Response Epidermal Growth Factor Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling I-kappaB Phosphorylation Rho Protein Signal Transduction Lactation Fibroblast Growth Factor Receptor Signaling Pathway Response To Virus Response To Toxic Substance Anatomical Structure Morphogenesis Osteoclast Differentiation Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Response To Hydroperoxide Mammary Gland Epithelial Cell Proliferation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Odontogenesis Of Dentin-containing Tooth Response To Drug Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Amino Acid Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Striated Muscle Cell Differentiation Mammary Gland Alveolus Development Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Response To Tumor Necrosis Factor
Pathways			Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Signaling by EGFRvIII in Cancer AKT phosphorylates targets in the cytosol RIP-mediated NFkB activation via ZBP1 IRAK1 recruits IKK complex Signaling by SCF-KIT Toll Like Receptor TLR1:TLR2 Cascade DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) FCERI mediated NF-kB activation PI3K/AKT activation Toll Like Receptor 5 (TLR5) Cascade PI-3K cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade IRAK1 recruits IKK complex Signaling by PDGF DAP12 interactions GAB1 signalosome TRIF-mediated TLR3/TLR4 signaling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins TCR signaling Downstream signal transduction Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling PI3K/AKT Signaling in Cancer TAK1 activates NFkB by phosphorylation and activation of IKKs complex Adaptive Immune System Downstream TCR signaling PIP3 activates AKT signaling Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs PI3K events in ERBB2 signaling Downstream signaling of activated FGFR TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Innate Immune System Signalling by NGF IKK complex recruitment mediated by RIP1 Cytosolic sensors of pathogen-associated DNA Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Signaling by FGFR RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Activation of NF-kappaB in B cells TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS			Liver enzyme levels ( 18940312)
Protein-Protein Interactions		27 interactors: AKT1 APP CDC42 CHUK CLEC4G COPS5 EPS8 IKBKB KIF17 KIF3A KIF3B KIFAP3 MAP2K4 MAP2K7 MAP3K12 MAP4K1 MAP4K2 MAPK8IP1 MAPK8IP2 MAPK8IP3 PIN1 RAC1 RHOG SH3RF1 STUB1 TRAF6 UBC	75 interactors: AKT1 AKT2 BCL10 BTRC CASP8 CDC37 CHEK1 COPS5 CREBBP CSF2RA CSNK2A1 CTNNB1 CUEDC2 CUL1 EIF2AK2 ERBB2IP ESR1 FKBP5 FOXO3 HIST2H3C HIST3H3 HSP90AA1 HSP90AB1 HTT IKBKAP IKBKB IKBKE IKBKG IRS1 MAP3K1 MAP3K11 MAP3K14 MAP3K4 MAP3K7 MAP3K8 NCOA3 NCOR1 NCOR2 NFKB1 NFKB2 NFKBIA NFKBIB NLRP4 NOTCH3 NR2C2 PAX8 PEBP1 PIAS1 PRKCB PRKCI PRKCQ PRKDC PTPN11 RELA RICTOR RIPK2 RPL27 SRC SRPK1 SRPK2 STAP2 TANK TGFBR1 TNFAIP3 TNFRSF1A TNIP2 TP53 TRAF2 TRAF3IP2 TRAF4 TRIM27 TRPC4AP UBE2E3 UBE2I UBE2N
Entrez ID		4296	1147
HPRD ID		02502	02811
Ensembl ID		ENSG00000173327	ENSG00000213341
Uniprot IDs		Q16584	O15111
PDB IDs			3BRT
Enriched GO Terms of Interacting Partners?		Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade JNK Cascade Regulation Of MAPK Cascade Regulation Of Signal Transduction Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Transferase Activity Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Phosphorylation Response To Stress Regulation Of Phosphorus Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Kinase Activity MAPK Cascade Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Kinase Activity Signal Transduction By Phosphorylation Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Phosphorylation Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Protein Metabolic Process Regulation Of JUN Kinase Activity Fc Receptor Signaling Pathway Innate Immune Response Positive Regulation Of MAPK Cascade Signal Transduction Toll-like Receptor 5 Signaling Pathway Positive Regulation Of Metabolic Process Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Protein Kinase Activity Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Immune System Process Toll-like Receptor 2 Signaling Pathway Positive Regulation Of JNK Cascade Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway	Innate Immune Response Immune Response Immune Response-regulating Signaling Pathway Signal Transduction Positive Regulation Of Cellular Metabolic Process Immune System Process Signaling Defense Response Positive Regulation Of Metabolic Process Cell Communication Regulation Of Signal Transduction Regulation Of Innate Immune Response Cellular Response To Organic Substance Regulation Of Signaling Regulation Of Immune Response Regulation Of Immune System Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor Signaling Pathway Positive Regulation Of Signal Transduction Intracellular Signal Transduction Activation Of Innate Immune Response Cellular Response To Stimulus Regulation Of Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Organic Substance Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Immune System Process Positive Regulation Of Innate Immune Response Toll-like Receptor 3 Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Cell Death Death Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Programmed Cell Death Regulation Of Metabolic Process Response To Stimulus TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Modification Process MyD88-independent Toll-like Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Phosphorylation Response To Stress
Tagcloud ?		acceleration activate agar besides carcinogenesis cdk2 colony crkl cycle cycling1 facilitate g1 htert mb mda methylate methyltransferase mynd oncogenes phenotypes pik3cb riz set smyd3 soft stat1 transduction transformed wnt10b	accentuated analog analogs antineoplastic attributes coincided confined correspond cyclooxygenase encountered govern implying instance krox microtubule modulates oligoadenylate oncology originate prompts questions simply stabilization taxane taxol taxotere termed traits unidentified
Tagcloud (Difference) ?		acceleration activate agar besides carcinogenesis cdk2 colony crkl cycle cycling1 facilitate g1 htert mb mda methylate methyltransferase mynd oncogenes phenotypes pik3cb riz set smyd3 soft stat1 transduction transformed wnt10b	accentuated analog analogs antineoplastic attributes coincided confined correspond cyclooxygenase encountered govern implying instance krox microtubule modulates oligoadenylate oncology originate prompts questions simply stabilization taxane taxol taxotere termed traits unidentified
Tagcloud (Intersection) ?