MAP3K11 and KIF17

Number of citations of the paper that reports this interaction (PubMedID 9427749)
51

Data Source:
BioGRID (two hybrid)

		MAP3K11	KIF17
Description		mitogen-activated protein kinase kinase kinase 11	kinesin family member 17
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Membrane	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Microtubule Organizing Center Cytosol Cytoskeleton Kinesin Complex Microtubule Cilium Axoneme Microtubule Cytoskeleton Dendrite Photoreceptor Connecting Cilium Dendrite Cytoplasm Ciliary Basal Body Cell Projection Neuron Projection Postsynapse Periciliary Membrane Compartment
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Small GTPase Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine Kinase Activity	Nucleotide Binding Microtubule Motor Activity ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity ATP Hydrolysis Activity
	Biological Process	MAPK Cascade Protein Phosphorylation Microtubule-based Process JNK Cascade Positive Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Apoptotic Process Cell Cycle G1/S Phase Transition Positive Regulation Of JNK Cascade Protein Autophosphorylation	Microtubule-based Process Microtubule-based Movement Protein Transport Vesicle-mediated Transport Cell Projection Organization Protein-containing Complex Localization Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex
Pathways		RAF activation Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF CDC42 GTPase cycle RHOG GTPase cycle RHOV GTPase cycle Signaling downstream of RAS mutants	Intraflagellar transport Assembly and cell surface presentation of NMDA receptors
Drugs		Fostamatinib
Diseases
GWAS		Acne (severe) ( 24927181 30542056) Coronary artery disease ( 29212778) Eosinophil count ( 27863252) Estimated glomerular filtration rate ( 31015462) Gout ( 25646370) Mean platelet volume ( 27863252) Refractive error ( 32231278) Serum uric acid levels ( 32514006) Sum eosinophil basophil counts ( 27863252) Type 2 diabetes ( 28566273 30297969) Waist circumference adjusted for body mass index ( 34021172)	Ceramide levels (C24:0) ( 32489964) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Type 1 diabetes (age at diagnosis) ( 33179336)
Interacting Genes		29 interacting genes: AKT1 APP CDC42 CHUK CLEC4G COPS5 DSCAM EPS8 IKBKB KIF17 KIF3A KIF3B KIFAP3 LATS1 MAP2K4 MAP2K7 MAP3K12 MAP3K21 MAP4K1 MAP4K2 MAPK8IP1 MAPK8IP2 MAPK8IP3 PIN1 RAC1 RHOG SH3RF1 STUB1 TRAF6	8 interacting genes: APBA1 FHL5 FXR1 GFI1B MAP3K10 MAP3K11 PHAF1 XPO1
Entrez ID		4296	57576
HPRD ID		02502	10388
Ensembl ID		ENSG00000173327	ENSG00000117245
Uniprot IDs		Q16584	A0A0A0MRS8 Q9P2E2
PDB IDs		5K26 5K28 6AQB 6CQ7
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette MAPK Cascade Intracellular Signal Transduction Regulation Of JNK Cascade Regulation Of MAPK Cascade JNK Cascade Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Postsynapse Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Positive Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Nucleotide Binding Kinesin II Complex MAP-kinase Scaffold Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Axo-dendritic Transport Protein Kinase Binding Protein Serine Kinase Activity Regulation Of Apoptotic Process Protein Kinase Activity Transport Along Microtubule Regulation Of Programmed Cell Death Signal Transduction Glutamatergic Synapse Cytoskeleton-dependent Intracellular Transport Fc-epsilon Receptor Signaling Pathway Plus-end-directed Vesicle Transport Along Microtubule Regulation Of Signal Transduction ATP Binding Microtubule-based Transport Kinase Activity Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Plus-end-directed Organelle Transport Along Microtubule Regulation Of Postsynapse Organization Cell Projection Organization CD40 Receptor Complex Anterograde Dendritic Transport JUN Kinase Binding Regulation Of Phosphorus Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of Phosphorylation Photoreceptor Connecting Cilium Kinesin Binding Kinesin Complex Establishment Of Vesicle Localization Cytoplasm	JUN Kinase Kinase Kinase Activity Positive Regulation Of JUN Kinase Activity MAP Kinase Kinase Kinase Activity Positive Regulation Of MAP Kinase Activity Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Protein Serine/threonine Kinase Activity JNK Cascade Regulation Of MAP Kinase Activity Cellular Localization Dendritic Spine Regulation Of Macromolecule Metabolic Process Gamma-aminobutyric Acid Secretion Positive Regulation Of Kinase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Protein Kinase Activity Negative Regulation Of RNA Metabolic Process Protein Autophosphorylation Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of JNK Cascade Protein Homodimerization Activity Regulation Of JNK Cascade Regulation Of Protein Metabolic Process Annulate Lamellae Cellular Response To Salt Ribosomal Small Subunit Export From Nucleus Response To Triglyceride Ribosomal Large Subunit Export From Nucleus MRNA Transport Cellular Response To Triglyceride RNA Transport RNA Strand Annealing Activity Nuclear Pore Localization Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Intracellular Membraneless Organelle Regulation Of Metabolic Process Nucleobase-containing Compound Transport Nuclear Envelope Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Protein Phosphorylation MAPK Cascade Mitogen-activated Protein Kinase Kinase Binding Nuclear Export Signal Receptor Activity Ribosomal Subunit Export From Nucleus Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of MiRNA-mediated Gene Silencing Nuclear Pore Complex Assembly Positive Regulation Of Phosphorylation Regulation Of Kinase Activity
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