MAP3K11 and MAP3K21

Number of citations of the paper that reports this interaction (PubMedID 28757353)
33

Data Source:
BioGRID (pull down, affinity chromatography technology)

		MAP3K11	MAP3K21
Description		mitogen-activated protein kinase kinase kinase 11	mitogen-activated protein kinase kinase kinase 21
Image
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Membrane	Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Small GTPase Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Homodimerization Activity Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Protein Phosphorylation Microtubule-based Process JNK Cascade Positive Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Apoptotic Process Cell Cycle G1/S Phase Transition Positive Regulation Of JNK Cascade Protein Autophosphorylation	MAPK Cascade Protein Phosphorylation Signal Transduction Protein Autophosphorylation
Pathways		RAF activation Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF CDC42 GTPase cycle RHOG GTPase cycle RHOV GTPase cycle Signaling downstream of RAS mutants
Drugs		Fostamatinib
Diseases
GWAS		Acne (severe) ( 24927181 30542056) Coronary artery disease ( 29212778) Eosinophil count ( 27863252) Estimated glomerular filtration rate ( 31015462) Gout ( 25646370) Mean platelet volume ( 27863252) Refractive error ( 32231278) Serum uric acid levels ( 32514006) Sum eosinophil basophil counts ( 27863252) Type 2 diabetes ( 28566273 30297969) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		29 interacting genes: AKT1 APP CDC42 CHUK CLEC4G COPS5 DSCAM EPS8 IKBKB KIF17 KIF3A KIF3B KIFAP3 LATS1 MAP2K4 MAP2K7 MAP3K12 MAP3K21 MAP4K1 MAP4K2 MAPK8IP1 MAPK8IP2 MAPK8IP3 PIN1 RAC1 RHOG SH3RF1 STUB1 TRAF6	3 interacting genes: CLK1 MAP3K11 STUB1
Entrez ID		4296	84451
HPRD ID		02502	10087
Ensembl ID		ENSG00000173327	ENSG00000143674
Uniprot IDs		Q16584	Q5TCX8
PDB IDs		5K26 5K28 6AQB 6CQ7	4UYA
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette MAPK Cascade Intracellular Signal Transduction Regulation Of JNK Cascade Regulation Of MAPK Cascade JNK Cascade Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Postsynapse Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Positive Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Nucleotide Binding Kinesin II Complex MAP-kinase Scaffold Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Axo-dendritic Transport Protein Kinase Binding Protein Serine Kinase Activity Regulation Of Apoptotic Process Protein Kinase Activity Transport Along Microtubule Regulation Of Programmed Cell Death Signal Transduction Glutamatergic Synapse Cytoskeleton-dependent Intracellular Transport Fc-epsilon Receptor Signaling Pathway Plus-end-directed Vesicle Transport Along Microtubule Regulation Of Signal Transduction ATP Binding Microtubule-based Transport Kinase Activity Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Plus-end-directed Organelle Transport Along Microtubule Regulation Of Postsynapse Organization Cell Projection Organization CD40 Receptor Complex Anterograde Dendritic Transport JUN Kinase Binding Regulation Of Phosphorus Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of Phosphorylation Photoreceptor Connecting Cilium Kinesin Binding Kinesin Complex Establishment Of Vesicle Localization Cytoplasm	Positive Regulation Of Chaperone-mediated Protein Complex Assembly Protein Serine/threonine Kinase Activity Transferase Activity Protein Serine Kinase Activity Protein Kinase Activity Mitogen-activated Protein Kinase Kinase Binding Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Modification Process Positive Regulation Of Apoptotic Process JUN Kinase Kinase Kinase Activity Positive Regulation Of JUN Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding MAPK Cascade Chaperone-mediated Autophagy Positive Regulation Of ERAD Pathway Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Ubiquitin-ubiquitin Ligase Activity Nuclear Inclusion Body Regulation Of Glucocorticoid Metabolic Process Negative Regulation Of Vasoconstriction Regulation Of Vascular Associated Smooth Muscle Contraction Negative Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Vascular Associated Smooth Muscle Contraction Response To Misfolded Protein Cellular Response To Misfolded Protein TPR Domain Binding Ubiquitin Conjugating Enzyme Complex Positive Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Misfolded Protein Binding Negative Regulation Of Smooth Muscle Contraction Kinase Activity Regulation Of Protein Modification Process MAP Kinase Kinase Kinase Activity Negative Regulation Of Muscle Contraction ERBB2 Signaling Pathway Positive Regulation Of Mitophagy Protein Serine/threonine/tyrosine Kinase Activity Protein Homodimerization Activity Positive Regulation Of Autophagy Of Mitochondrion Regulation Of ERAD Pathway Cellular Response To Topologically Incorrect Protein R-SMAD Binding Protein Folding Chaperone Complex Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Positive Regulation Of Protein Metabolic Process Positive Regulation Of MAP Kinase Activity Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Hormone Metabolic Process Negative Regulation Of Cardiac Muscle Hypertrophy
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?