LRRC25 and DEFB121

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LRRC25	DEFB121
Description		leucine rich repeat containing 25	defensin beta 121
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol Microtubule Cytoskeleton Membrane	Extracellular Region
	Molecular Function	Protein Binding	Protein Binding
	Biological Process		Defense Response Defense Response To Bacterium Innate Immune Response Defense Response To Gram-negative Bacterium
Pathways			Beta defensins Defensins
Drugs
Diseases
GWAS		Body size at age 10 ( 32376654) Hyperemesis gravidarum ( 29563502) Monocyte percentage of white cells ( 27863252 32888494) Severity of nausea and vomiting of pregnancy ( 29563502) Systemic lupus erythematosus ( 28714469 33536424) White blood cell count ( 32888494)	Liver enzyme levels (alkaline phosphatase) ( 33972514) Prudent dietary pattern ( 28644415)
Interacting Genes		38 interacting genes: ACD AGPAT4 ANKRD46 APOL3 ATP6V0C BMP10 BRICD5 C3orf52 CD72 CLDN19 CLEC1A CLN6 CLRN2 CNIH3 CXCL9 DEFB121 DNAJC30 EDDM3B FAM3C FATE1 FPR2 GPRC5D LHFPL5 MAL OPRM1 PKMYT1 PNLIPRP1 SEC22A SEC61G SMCO4 SPNS3 TMEM120A TMEM201 TNF TRAF3IP3 TSPAN4 VAMP5 YIPF6	10 interacting genes: CD40 CLEC2D FAM209A GJA8 IL27RA LAYN LRRC25 NECTIN4 SSMEM1 SYNE4
Entrez ID		126364	245934
HPRD ID		09597	16791
Ensembl ID		ENSG00000175489	ENSG00000204548
Uniprot IDs		Q8N386	A0A384MDM0 Q5GRF9 Q5J5C9
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Detection Of Mechanical Stimulus Involved In Sensory Perception	Regulation Of Isotype Switching To IgG Isotypes Regulation Of Isotype Switching Regulation Of Lymphocyte Mediated Immunity Membrane Negative Regulation Of T Cell Extravasation Regulation Of Immunoglobulin Production Interleukin-27 Receptor Activity Positive Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Protein Kinase C Signaling Response To Cobalamin
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