LRRC25 and SEC61G

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LRRC25	SEC61G
Description		leucine rich repeat containing 25	SEC61 translocon subunit gamma
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol Microtubule Cytoskeleton Membrane	Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Cytosol Membrane Ssh1 Translocon Complex
	Molecular Function	Protein Binding	Protein Binding Protein Transmembrane Transporter Activity Ribosome Binding
	Biological Process		Protein Targeting Intracellular Protein Transport Protein Transport Post-translational Protein Targeting To Membrane, Translocation Protein Targeting To ER
Pathways			ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS		Body size at age 10 ( 32376654) Hyperemesis gravidarum ( 29563502) Monocyte percentage of white cells ( 27863252 32888494) Severity of nausea and vomiting of pregnancy ( 29563502) Systemic lupus erythematosus ( 28714469 33536424) White blood cell count ( 32888494)	Metabolite levels ( 23823483) Systemic lupus erythematosus ( 24871463) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		38 interacting genes: ACD AGPAT4 ANKRD46 APOL3 ATP6V0C BMP10 BRICD5 C3orf52 CD72 CLDN19 CLEC1A CLN6 CLRN2 CNIH3 CXCL9 DEFB121 DNAJC30 EDDM3B FAM3C FATE1 FPR2 GPRC5D LHFPL5 MAL OPRM1 PKMYT1 PNLIPRP1 SEC22A SEC61G SMCO4 SPNS3 TMEM120A TMEM201 TNF TRAF3IP3 TSPAN4 VAMP5 YIPF6	10 interacting genes: AQP6 CREB3 CREB3L1 FAM209A LCN2 LRRC25 PEX12 SEC61A1 SFTPC TMEM51
Entrez ID		126364	23480
HPRD ID		09597	15318
Ensembl ID		ENSG00000175489	ENSG00000132432
Uniprot IDs		Q8N386	P60059
PDB IDs			6W6L 8B6L 8DNV 8DNW 8DNX 8DNY 8DNZ 8DO0 8DO1 8DO2 8DO3 8OJ0 8OJ8
Enriched GO Terms of Interacting Partners?		Membrane Detection Of Mechanical Stimulus Involved In Sensory Perception	Intracellular Protein Transmembrane Transport Protein Transmembrane Transporter Activity Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport Positive Regulation Of Iron Ion Import Across Plasma Membrane Positive Regulation Of Hippocampal Neuron Apoptotic Process Enterobactin Binding Positive Regulation Of Endothelial Tube Morphogenesis Iron Ion Sequestering Activity Protein Transmembrane Transport Response To Unfolded Protein Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Deacetylase Activity Negative Regulation Of Response To Endoplasmic Reticulum Stress Pronephric Nephron Development Regulation Of Response To Endoplasmic Reticulum Stress Siderophore Transport Cellular Response To Reactive Oxygen Species Peroxisomal Importomer Complex Extracellular Matrix Constituent Secretion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Cytoplasmic Vesicle Lumen Negative Regulation Of Hippocampal Neuron Apoptotic Process Response To Kainic Acid Endoplasmic Reticulum Membrane Signal Sequence Binding Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Response To Herbicide Regulation Of Hippocampal Neuron Apoptotic Process Response To Mycotoxin Release From Viral Latency Regulation Of Iron Ion Transport Response To Blue Light Protein Import Into Peroxisome Matrix, Substrate Release Multivesicular Body Lumen Alveolar Lamellar Body CCR1 Chemokine Receptor Binding Sec61 Translocon Complex Response To Reactive Oxygen Species Response To Iron(II) Ion Regulation Of Endothelial Tube Morphogenesis Lamellar Body Monoatomic Anion Channel Activity Renal Water Transport SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Post-translational Protein Targeting To Membrane, Translocation
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