LRRC25 and FPR2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LRRC25	FPR2
Description		leucine rich repeat containing 25	formyl peptide receptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol Microtubule Cytoskeleton Membrane	Cytoplasm Plasma Membrane Membrane Specific Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding	Amyloid-beta Binding Complement Receptor Activity G Protein-coupled Receptor Activity N-formyl Peptide Receptor Activity Scavenger Receptor Binding Protein Binding Signaling Receptor Activity Cargo Receptor Activity RAGE Receptor Binding
	Biological Process		Microglial Cell Activation Complement Receptor Mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Receptor-mediated Endocytosis Chemotaxis Inflammatory Response Cell Communication Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Signaling Positive Regulation Of Superoxide Anion Generation Defense Response To Bacterium Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Innate Immune Response Astrocyte Activation Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Positive Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Monocyte Chemotaxis Dentinogenesis Cellular Response To Amyloid-beta
Pathways			G alpha (q) signalling events G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands Neutrophil degranulation
Drugs
Diseases
GWAS		Body size at age 10 ( 32376654) Hyperemesis gravidarum ( 29563502) Monocyte percentage of white cells ( 27863252 32888494) Severity of nausea and vomiting of pregnancy ( 29563502) Systemic lupus erythematosus ( 28714469 33536424) White blood cell count ( 32888494)	Alopecia areata ( 25608926) Multiple sclerosis ( 24076602 31604244) Tourette syndrome ( 30818990)
Interacting Genes		38 interacting genes: ACD AGPAT4 ANKRD46 APOL3 ATP6V0C BMP10 BRICD5 C3orf52 CD72 CLDN19 CLEC1A CLN6 CLRN2 CNIH3 CXCL9 DEFB121 DNAJC30 EDDM3B FAM3C FATE1 FPR2 GPRC5D LHFPL5 MAL OPRM1 PKMYT1 PNLIPRP1 SEC22A SEC61G SMCO4 SPNS3 TMEM120A TMEM201 TNF TRAF3IP3 TSPAN4 VAMP5 YIPF6	5 interacting genes: APOD CAMP FXYD6 LRRC25 SSMEM1
Entrez ID		126364	2358
HPRD ID		09597	00647
Ensembl ID		ENSG00000175489	ENSG00000171049
Uniprot IDs		Q8N386	P25090
PDB IDs			6LW5 6OMM 7T6S 7T6U 7T6V 7WVV 7WVW 7WVX 7WVY 8Y62 8Y63
Enriched GO Terms of Interacting Partners?		Membrane Detection Of Mechanical Stimulus Involved In Sensory Perception	Regulation Of Chemokine Production Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Cellular Response To Butyrate Prostaglandin Production Involved In Inflammatory Response Positive Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Response To Butyrate I-kappaB Phosphorylation Presynaptic Membrane Regulation Of Smooth Muscle Cell-matrix Adhesion Arachidonate Metabolite Production Involved In Inflammatory Response Negative Regulation Of Lipoprotein Metabolic Process Peripheral Nervous System Axon Regeneration Negative Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of T Cell Migration Cellular Response To Peptidoglycan Dentinogenesis Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Positive Regulation Of Antimicrobial Humoral Response Structural Constituent Of Presynaptic Active Zone IkappaB Kinase Complex Ion Channel Regulator Activity Maintenance Of Presynaptic Active Zone Structure Positive Regulation Of Sodium Ion Export Across Plasma Membrane Chronic Inflammatory Response Presynaptic Active Zone Organization Cytolysis By Host Of Symbiont Cells Antifungal Humoral Response Regulation Of Antimicrobial Humoral Response Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Lipoprotein Metabolic Process Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Specific Granule Positive Regulation Of Monocyte Chemotactic Protein-1 Production Production Of Molecular Mediator Involved In Inflammatory Response Cytolysis Response To Peptidoglycan Presynaptic Active Zone Cytoplasmic Component Negative Regulation Of Lymphocyte Migration Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Response To Yeast
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