GLRX and MMP23B

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GLRX	MMP23B
Description		glutaredoxin	matrix metallopeptidase 23B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome	Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Extracellular Matrix
	Molecular Function	Protein Binding Disulfide Oxidoreductase Activity Glutathione Disulfide Oxidoreductase Activity Sodium Channel Regulator Activity	Metalloendopeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Nucleobase-containing Small Molecule Interconversion Positive Regulation Of Membrane Potential	Proteolysis Extracellular Matrix Organization Collagen Catabolic Process
Pathways		Interconversion of nucleotide di- and triphosphates
Drugs		Glutathione	Marimastat
Diseases
GWAS		hemolysis of donated blood (oxidative) ( 34014839) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Metabolite levels ( 23823483) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)	Body mass index ( 26426971)
Interacting Genes		8 interacting genes: AQP5 CASP3 GOT2 MAP3K5 MMP23B NFIC PTPN1 TRIM62	2 interacting genes: GLRX SRPK2
Entrez ID		2745	8510
HPRD ID		02707	04503
Ensembl ID		ENSG00000173221	ENSG00000189409
Uniprot IDs		P35754	O75900
PDB IDs		1B4Q 1JHB 4RQR
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Cellular Response To Reactive Nitrogen Species Cellular Response To Osmotic Stress Cellular Response To Chemical Stress Regulation Of Cardiac Muscle Cell Apoptotic Process Response To Osmotic Stress Odontogenesis Response To Hydrogen Peroxide Phospholipase A2 Activator Activity L-glutamate Catabolic Process To Aspartate L-aspartate:2-oxoglutarate Aminotransferase Activity Aspartate Biosynthetic Process Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of JNK Cascade Pancreatic Juice Secretion Positive Regulation Of Programmed Cell Death Anterior Neural Tube Closure Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Positive Regulation Of Apoptotic Process Response To Tumor Necrosis Factor Cellular Response To Staurosporine Neuron Apoptotic Process Luteolysis Glial Cell Apoptotic Process Response To Reactive Oxygen Species L-aspartate Catabolic Process Trans-4-hydroxy-L-proline Catabolic Process Kynurenine-oxoglutarate Transaminase Activity Protein Kinase Complex IRE1-TRAF2-ASK1 Complex Regulation Of JNK Cascade Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Insulin Receptor Recycling Positive Regulation Of Antifungal Innate Immune Response Saliva Secretion Response To Anesthetic Intrinsic Apoptotic Signaling Pathway Sorting Endosome Endoplasmic Reticulum Death-inducing Signaling Complex Aspartate Metabolic Process Cellular Response To Stress Oxaloacetate Metabolic Process L-glutamate Catabolic Process Malate-aspartate Shuttle Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of IRE1-mediated Unfolded Protein Response Mitochondrial Crista Positive Regulation Of Pyroptotic Inflammatory Response	Glutathione Disulfide Oxidoreductase Activity Methylenetetrahydrofolate Reductase (NADPH) Activity Methylenetetrahydrofolate Reductase [NAD(P)H] Activity Response To Vitamin B2 Disulfide Oxidoreductase Activity Nucleobase-containing Small Molecule Interconversion Positive Regulation Of Membrane Potential Methionine Biosynthetic Process S-adenosylmethionine Metabolic Process Modified Amino Acid Binding Heterochromatin Organization Response To Folic Acid Tetrahydrofolate Interconversion R-loop Processing Nuclear Speck Organization Methionine Metabolic Process Homocysteine Metabolic Process Sulfur Amino Acid Biosynthetic Process Tetrahydrofolate Metabolic Process Nuclear Body Organization One-carbon Metabolic Process Folic Acid-containing Compound Metabolic Process Sodium Channel Regulator Activity Sulfur Amino Acid Metabolic Process Pteridine-containing Compound Metabolic Process 14-3-3 Protein Binding Positive Regulation Of Viral Genome Replication Aspartate Family Amino Acid Metabolic Process NADP Binding FAD Binding Anatomical Structure Formation Involved In Morphogenesis Chromatin Organization Peptidyl-serine Phosphorylation Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Flavin Adenine Dinucleotide Binding Positive Regulation Of Viral Process Amino Acid Biosynthetic Process
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