GLRX and GOT2

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		GLRX	GOT2
Name		glutaredoxin	glutamic-oxaloacetic transaminase 2
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome	Mitochondrion Mitochondrial Matrix Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Protein Binding Disulfide Oxidoreductase Activity Glutathione Disulfide Oxidoreductase Activity Sodium Channel Regulator Activity	RNA Binding Catalytic Activity L-aspartate:2-oxoglutarate Aminotransferase Activity Transaminase Activity Kynurenine-oxoglutarate Transaminase Activity Transferase Activity Pyridoxal Phosphate Binding
	Biological Process	Nucleobase-containing Small Molecule Interconversion Positive Regulation Of Membrane Potential	2-oxoglutarate Metabolic Process Oxaloacetate Metabolic Process Amino Acid Metabolic Process Aspartate Metabolic Process Aspartate Biosynthetic Process L-aspartate Catabolic Process Glutamate Metabolic Process L-glutamate Catabolic Process Lipid Transport Fatty Acid Transport Trans-4-hydroxy-L-proline Catabolic Process L-glutamate Catabolic Process To Aspartate Malate-aspartate Shuttle Response To Ethanol
Pathways		Interconversion of nucleotide di- and triphosphates	Degradation of cysteine and homocysteine Glyoxylate metabolism and glycine degradation Aspartate and asparagine metabolism Glutamate and glutamine metabolism Malate-aspartate shuttle
Drugs		Glutathione	Pyridoxal phosphate Aspartic acid Glutamic acid Cysteine 4'-Deoxy-4'-Acetylyamino-Pyridoxal-5'-Phosphate
GWAS		hemolysis of donated blood (oxidative) ( 34014839 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Immature fraction of reticulocytes ( 27863252 32888494 ) Metabolite levels ( 23823483 ) Reticulocyte count ( 27863252 32888494 ) Reticulocyte fraction of red cells ( 27863252 32888494 )	Aortic root size ( 21223598 ) Aspartate aminotransferase levels ( 29403010 33339817 33547301 ) Automobile speeding propensity ( 30643258 ) High density lipoprotein cholesterol levels ( 33339817 ) Impulsivity (attentional) ( 30718321 ) Metabolite levels ( 23823483 ) QT interval ( 19305408 ) Serum metabolite levels ( 33031748 ) Triglyceride levels ( 32203549 ) Urinary metabolite levels in chronic kidney disease ( 31959995 ) Uterine fibroid number (single vs multiple) ( 30196971 )
Novel Interactors		None recorded	2 novel interactors: BBS2 CSNK2A2
Interacting Genes		8 interacting genes: AQP5 CASP3 GOT2 MAP3K5 MMP23B NFIC PTPN1 TRIM62	10 interacting genes: APCS CCL21 GAPDH GLRX GLUD1 HSPA8 MDH2 PC THOC7 ZDHHC6
Entrez ID		2745	2806
HPRD ID		02707	00684
Ensembl ID		ENSG00000173221	ENSG00000125166
Uniprot IDs		P35754	P00505
PDB IDs		1B4Q 1JHB 4RQR	5AX8 8SKR
GO Terms Enriched among Interactors		Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Cellular Response To Reactive Nitrogen Species Cellular Response To Osmotic Stress Cellular Response To Chemical Stress Regulation Of Cardiac Muscle Cell Apoptotic Process Response To Osmotic Stress Odontogenesis Response To Hydrogen Peroxide Phospholipase A2 Activator Activity L-glutamate Catabolic Process To Aspartate L-aspartate:2-oxoglutarate Aminotransferase Activity Aspartate Biosynthetic Process Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of JNK Cascade Pancreatic Juice Secretion Positive Regulation Of Programmed Cell Death Anterior Neural Tube Closure Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Positive Regulation Of Apoptotic Process Response To Tumor Necrosis Factor Cellular Response To Staurosporine Neuron Apoptotic Process Luteolysis Glial Cell Apoptotic Process Response To Reactive Oxygen Species L-aspartate Catabolic Process Trans-4-hydroxy-L-proline Catabolic Process Kynurenine-oxoglutarate Transaminase Activity Protein Kinase Complex IRE1-TRAF2-ASK1 Complex Regulation Of JNK Cascade Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Insulin Receptor Recycling Positive Regulation Of Antifungal Innate Immune Response Saliva Secretion Response To Anesthetic Intrinsic Apoptotic Signaling Pathway Sorting Endosome Endoplasmic Reticulum Death-inducing Signaling Complex Aspartate Metabolic Process Cellular Response To Stress Oxaloacetate Metabolic Process L-glutamate Catabolic Process Malate-aspartate Shuttle Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of IRE1-mediated Unfolded Protein Response Mitochondrial Crista Positive Regulation Of Pyroptotic Inflammatory Response	Glucose Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Nicotinamide Nucleotide Metabolic Process Purine Nucleotide Metabolic Process Nucleotide Metabolic Process Hexose Metabolic Process Small Molecule Metabolic Process Monosaccharide Metabolic Process Purine-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleoside Phosphate Metabolic Process Chaperone-mediated Autophagy Translocation Complex Disassembly NAD+ Metabolic Process L-malate Dehydrogenase (NADP+) Activity Hexose Biosynthetic Process Gluconeogenesis Pyruvate Carboxylase Activity Dendritic Cell Dendrite Assembly Negative Regulation Of Dendritic Cell Dendrite Assembly Host-mediated Perturbation Of Viral Process Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Peptidyl-cysteine S-trans-nitrosylation Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Glutathione Disulfide Oxidoreductase Activity Glutamate Dehydrogenase (NAD+) Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, NAD Or NADP As Acceptor Glutamate Dehydrogenase (NADP+) Activity Glutamate Dehydrogenase [NAD(P)+] Activity Lumenal Side Of Lysosomal Membrane Viral RNA Genome Packaging Positive Regulation Of Myeloid Dendritic Cell Chemotaxis Mesangial Cell-matrix Adhesion CCR7 Chemokine Receptor Binding CCL21-activated CCR7 Signaling Pathway Cerebral Cortex Development Dicarboxylic Acid Metabolic Process Protein Kinase CK2 Complex Peptidyl-cysteine S-nitrosylase Activity Regulation Of Protein Import L-malate Dehydrogenase (NAD+) Activity Malate Dehydrogenase Activity Regulation Of Dendritic Cell Dendrite Assembly Unfolded Protein Binding Host-mediated Perturbation Of Symbiont Process Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Carbohydrate Metabolic Process Peptidyl-cysteine S-nitrosylation GAIT Complex Mitochondrial Matrix Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy