GLRX and NFIC

Number of citations of the paper that reports this interaction (PubMedID 9417094)
0

Data Source:
HPRD (in vitro, in vivo)

		GLRX	NFIC
Description		glutaredoxin	nuclear factor I C
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome	Chromatin Fibrillar Center Nucleus Nucleoplasm
	Molecular Function	Protein Binding Disulfide Oxidoreductase Activity Glutathione Disulfide Oxidoreductase Activity Sodium Channel Regulator Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Nucleobase-containing Small Molecule Interconversion Positive Regulation Of Membrane Potential	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Odontogenesis Of Dentin-containing Tooth Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Interconversion of nucleotide di- and triphosphates	RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation
Drugs		Glutathione
Diseases
GWAS		hemolysis of donated blood (oxidative) ( 34014839) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Metabolite levels ( 23823483) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)	Alzheimer's disease (APOE e4 interaction) ( 28183528) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Automobile speeding propensity ( 30643258) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Height ( 20881960 31562340 28552196 25282103) High light scatter reticulocyte count ( 32888494) Hip circumference ( 28552196) Hip circumference adjusted for BMI ( 28552196) Monocyte count ( 32888494) Nevus count or cutaneous melanoma ( 30429480) Platelet count ( 32888494) Plateletcrit ( 32888494) Serum urate levels in chronic kidney disease ( 30181573) Weight ( 28552196) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		8 interacting genes: AQP5 CASP3 GOT2 MAP3K5 MMP23B NFIC PTPN1 TRIM62	54 interacting genes: CBLC CREBBP ELK3 EPHA2 ERG ETV7 FBXO7 FOS FOXL1 GATA2 GATA3 GLIS1 GLIS2 GLRX KLF16 KLF8 LATS2 LHX2 LHX3 LHX4 LLPH MAP2K3 MAPK14 MYC NFIB NSD3 PAX2 PAX6 PAX7 PAX8 PRDM1 RFX1 SFN SOX10 SOX15 SOX17 SOX2 SOX3 SOX5 SOX6 SOX9 SP7 TBR1 TBXT TEAD2 TKTL2 TLX1 TLX2 TLX3 TPD52L3 UBC YY1 ZCCHC14 ZKSCAN7
Entrez ID		2745	4782
HPRD ID		02707	09009
Ensembl ID		ENSG00000173221	ENSG00000141905
Uniprot IDs		P35754	B7Z4T6 P08651
PDB IDs		1B4Q 1JHB 4RQR
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Cellular Response To Reactive Nitrogen Species Cellular Response To Osmotic Stress Cellular Response To Chemical Stress Regulation Of Cardiac Muscle Cell Apoptotic Process Response To Osmotic Stress Odontogenesis Response To Hydrogen Peroxide Phospholipase A2 Activator Activity L-glutamate Catabolic Process To Aspartate L-aspartate:2-oxoglutarate Aminotransferase Activity Aspartate Biosynthetic Process Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of JNK Cascade Pancreatic Juice Secretion Positive Regulation Of Programmed Cell Death Anterior Neural Tube Closure Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Positive Regulation Of Apoptotic Process Response To Tumor Necrosis Factor Cellular Response To Staurosporine Neuron Apoptotic Process Luteolysis Glial Cell Apoptotic Process Response To Reactive Oxygen Species L-aspartate Catabolic Process Trans-4-hydroxy-L-proline Catabolic Process Kynurenine-oxoglutarate Transaminase Activity Protein Kinase Complex IRE1-TRAF2-ASK1 Complex Regulation Of JNK Cascade Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Insulin Receptor Recycling Positive Regulation Of Antifungal Innate Immune Response Saliva Secretion Response To Anesthetic Intrinsic Apoptotic Signaling Pathway Sorting Endosome Endoplasmic Reticulum Death-inducing Signaling Complex Aspartate Metabolic Process Cellular Response To Stress Oxaloacetate Metabolic Process L-glutamate Catabolic Process Malate-aspartate Shuttle Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of IRE1-mediated Unfolded Protein Response Mitochondrial Crista Positive Regulation Of Pyroptotic Inflammatory Response	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Regulation Of Transcription By RNA Polymerase II DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Animal Organ Development Cellular Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Neuron Differentiation Nucleus Sequence-specific DNA Binding Cell Fate Specification Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Developmental Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Developmental Process Positive Regulation Of Metabolic Process Cell Fate Commitment Regulation Of Cell Differentiation Anatomical Structure Morphogenesis Negative Regulation Of Developmental Process Regulation Of MiRNA Transcription Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process
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