MAP3K4 and EPHB4

		MAP3K4	EPHB4
Description		mitogen-activated protein kinase kinase kinase 4	EPH receptor B4
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Perinuclear Region Of Cytoplasm	Extracellular Region Cytosol Plasma Membrane Membrane Receptor Complex Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	MAPK Cascade Placenta Development Response To UV-C Regulation Of Gene Expression Male Germ-line Sex Determination Positive Regulation Of Telomere Maintenance Intracellular Signal Transduction P38MAPK Cascade Positive Regulation Of JUN Kinase Activity Chorionic Trophoblast Cell Differentiation Positive Regulation Of P38MAPK Cascade	Angiogenesis Cell Migration Involved In Sprouting Angiogenesis Heart Morphogenesis Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Signaling Pathway
Pathways			EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells
Drugs		Fostamatinib	Dasatinib N-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3,4,5- TRIMETHOXYPHENYL)PYRIMIDINE-2,4-DIAMINE N'-(3-CHLORO-4-METHOXY-PHENYL)-N-(3,4,5-TRIMETHOXYPHENYL)-1,3,5-TRIAZINE-2,4-DIAMINE 3-({4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl}amino)benzenesulfonamide N'-(5-chloro-1,3-benzodioxol-4-yl)-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine N-[3-[[4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL]AMINO]PHENYL]METHANESULFONAMIDE N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3-MORPHOLIN-4-YLPHENYL)PYRIMIDINE-2,4-DIAMINE 3-({4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL}AMINO)BENZAMIDE Tesevatinib Fostamatinib
Diseases
GWAS		Aging ( 22773346) Cognitive decline rate in late mild cognitive impairment ( 26252872) Lipoprotein (a) levels ( 26377243) Ovarian disease with few adhesions ( 28333195)	Bipolar disorder ( 31043756) Blond vs. brown/black hair color ( 30531825) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020) Platelet distribution width ( 32888494) Resting heart rate ( 27798624) Takayasu arteritis ( 33308445)
Interacting Genes		26 interacting genes: ANXA2 AXIN1 BUB1B CDC42 CHUK CNTRL DIXDC1 GADD45A GADD45B GADD45G GSK3B MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPK13 MFHAS1 PTK2B PTPN11 RAC1 RACGAP1 RUNX2 TPR TRAF4 YWHAZ	7 interacting genes: APP DTX3 EFNB2 FBXO7 GRIN1 SDC3 VCP
Entrez ID		4216	2050
HPRD ID		03886	02481
Ensembl ID		ENSG00000085511	ENSG00000196411
Uniprot IDs		F5H538 J3KNB8 Q9P1M2 Q9Y6R4	P54760 Q541P7 Q96L35
PDB IDs			2BBA 2E7H 2HLE 2QKQ 2VWU 2VWV 2VWW 2VWX 2VWY 2VWZ 2VX0 2VX1 2X9F 2XVD 2YN8 3ZEW 4AW5 4BB4 6FNI 6FNJ 6FNK 6FNL 6FNM
Enriched GO Terms of Interacting Partners?		Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Protein Kinase Binding Regulation Of Intracellular Signal Transduction Positive Regulation Of JNK Cascade Intracellular Signal Transduction Positive Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction MAP Kinase Kinase Activity Regulation Of JNK Cascade Signal Transduction Protein Kinase Activity Intracellular Signaling Cassette Regulation Of Cell Communication Kinase Activity Protein Tyrosine Kinase Activity Cytoplasm Protein Serine/threonine Kinase Activity Apoptotic Process Cellular Senescence Protein Serine Kinase Activity Nucleotide Binding MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Programmed Cell Death Cell Death Positive Regulation Of P38MAPK Cascade Cytosol Cell Surface Receptor Signaling Pathway Thioesterase Binding ATP Binding Regulation Of P38MAPK Cascade Regulation Of Organelle Organization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Modification Process Developmental Process Cellular Response To Sorbitol JUN Kinase Kinase Activity Regulation Of Cell Cycle Response To Stress Transferase Activity Regulation Of Protein Modification Process Regulation Of ERK1 And ERK2 Cascade Cellular Developmental Process Cytoskeleton Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Acetylcholine Receptor Activator Activity Amyloid-beta Complex Regulation Of Cellular Component Organization Regulation Of Neuronal Synaptic Plasticity Glutamate Receptor Signaling Pathway Regulation Of ATP Metabolic Process Positive Regulation Of Phosphate Metabolic Process Growth Cone Lamellipodium Synaptic Membrane Ionotropic Glutamate Receptor Signaling Pathway Response To Light Stimulus Regulation Of Cell Activation Visual Behavior Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Locomotion Perinuclear Region Of Cytoplasm Regulation Of Biological Quality Amylin Binding Response To Amyloid-beta Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of ATP Metabolic Process Ephrin Receptor Binding Positive Regulation Of Toll Signaling Pathway Visual Learning Cellular Response To Amyloid-beta Cell Adhesion Protein-containing Complex Lipoprotein Particle Extracellular Matrix Organization Regulation Of Receptor Internalization Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Protein Import Ligand-gated Ion Channel Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Extracellular Structure Organization Identical Protein Binding Negative Regulation Of Phosphate Transmembrane Transport Positive Regulation Of Wound Healing Establishment Of Endothelial Blood-brain Barrier Positive Regulation Of Aorta Morphogenesis Response To Glycine Propylene Metabolic Process Male Germ-line Sex Determination Flavin Adenine Dinucleotide Catabolic Process VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of Protein K63-linked Deubiquitination EMILIN Complex
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