MEF2A and DNMT3L

Number of citations of the paper that reports this interaction (PubMedID 24952347)
0

Data Source:
BioGRID (pull down)

		MEF2A	DNMT3L
Description		myocyte enhancer factor 2A	DNA methyltransferase 3 like
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol	Heterochromatin Condensed Nuclear Chromosome Nucleus Cytoplasm Cytosol ESC/E(Z) Complex Catalytic Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Histone Acetyltransferase Binding Histone Deacetylase Binding Sequence-specific DNA Binding SMAD Binding Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding	Protein Binding Enzyme Activator Activity Zinc Ion Binding Enzyme Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade DNA-templated Transcription Regulation Of DNA-templated Transcription Apoptotic Process Nervous System Development Heart Development Muscle Organ Development Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of D-glucose Import Mitochondrion Distribution Animal Organ Development Dendrite Morphogenesis Ventricular Cardiac Myofibril Assembly Cardiac Conduction ERK5 Cascade Cellular Response To Calcium Ion	Placenta Development DNA Methylation-dependent Constitutive Heterochromatin Formation Male Meiosis I Spermatogenesis Post-embryonic Development Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Cell Differentiation Methylation Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Epigenetic Programing Of Female Pronucleus Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Stem Cell Differentiation Chorionic Trophoblast Cell Differentiation Genomic Imprinting Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Transposable Element Silencing By Heterochromatin Formation Autosome Genomic Imprinting Transposable Element Silencing By PiRNA-mediated DNA Methylation
Pathways		ERK/MAPK targets Myogenesis	DNA methylation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Drugs
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Cervical cancer ( 28806749) Dental caries (decayed and filled deciduous teeth) ( 31533690) Gestational age at birth (maternal effect) ( 28598419) Systolic blood pressure ( 30224653 30578418)
Interacting Genes		30 interacting genes: ACTN4 ASCL1 CASP3 CASP7 CDK5 DDB1 DNMT3L EP300 ERBIN GABARAPL2 HAND1 HDAC4 HDAC5 HDAC7 HDAC9 HSF2BP MAPK14 MAPK7 MEF2D MEOX1 MYOD1 MYOG NDUFB9 PHB2 SMAD2 SMAD4 SUMO1 TEAD1 THRA VGLL4	78 interacting genes: - ASH2L ATF1 ATF2 ATF3 ATF4 BLZF1 CDX2 CREB1 CREBL2 CREM DDIT3 DLX4 DMTF1 DNMT3A DNMT3B DR1 E2F3 E2F5 E2F6 EGR1 EGR2 EGR4 ESR1 ESR2 ETS1 F2RL1 FOS FOSB FOSL1 FOSL2 GATA1 GMEB1 GSK3B GTF2H2 GTF2I GTF3C5 H2AC20 H2BC21 H3C14 H4C14 HAND1 HAND2 HDAC1 HNF4G HOXA5 HOXC11 ID1 JUN JUNB KLF12 LDB1 LHX2 MAFK MECP2 MED7 MEF2A MEF2D NFIL3 NFKB1 NR1H2 NR1I2 NR1I3 NR2E1 NR3C1 NR6A1 NUDT21 PDZD4 PHPT1 RELA RSL24D1 RXRA SMAD1 SMAD3 SMAD4 TLE5 TP53 YY1
Entrez ID		4205	29947
HPRD ID		02807	09417
Ensembl ID		ENSG00000068305	ENSG00000142182
Uniprot IDs		A0A0S2Z417 A0A0S2Z453 A0A0S2Z454 A0A0S2Z4C8 A0A0S2Z4N0 A0A8I5KVQ4 A8K720 Q02078	Q9UJW3
PDB IDs		1C7U 1EGW 1LEW 3KOV 3MU6 3P57 6BYY 6BZ1 7XUZ	2PV0 2PVC 2QRV 4U7P 4U7T 5YX2 6BRR 6F57 6KDA 6KDB 6KDL 6KDP 6KDT 6U8P 6U8V 6U8W 6U8X 6U90 6U91 6W89 6W8B 6W8D 6W8J 7X9D 8TCI 8XEE
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Cellular Developmental Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Cell Differentiation Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Myotube Differentiation Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Macromolecule Metabolic Process Developmental Process Nucleus Positive Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Macromolecule Biosynthetic Process Animal Organ Development Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Protein Lysine Deacetylase Activity Positive Regulation Of Biosynthetic Process Regulation Of Muscle Cell Differentiation DNA-binding Transcription Factor Activity Positive Regulation Of RNA Metabolic Process Heart Development Cell Fate Commitment DNA-binding Transcription Factor Binding Histone Deacetylase Activity Positive Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity Skeletal Muscle Tissue Development Striated Muscle Tissue Development Nucleoplasm Chromatin Striated Muscle Cell Differentiation	DNA-binding Transcription Factor Activity Chromatin DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Sequence-specific Double-stranded DNA Binding Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Transcription Cis-regulatory Region Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA Metabolic Process Cell Differentiation Regulation Of MiRNA Transcription Negative Regulation Of Metabolic Process Positive Regulation Of MiRNA Metabolic Process DNA-templated Transcription Positive Regulation Of MiRNA Transcription Cellular Developmental Process
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