MEF2A and ASCL1

Number of citations of the paper that reports this interaction (PubMedID 8662987)
0

Data Source:
HPRD (in vitro, in vivo)

		MEF2A	ASCL1
Description		myocyte enhancer factor 2A	achaete-scute family bHLH transcription factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol	Chromatin Nucleus Neuronal Cell Body RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Histone Acetyltransferase Binding Histone Deacetylase Binding Sequence-specific DNA Binding SMAD Binding Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Nucleic Acid Binding DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade DNA-templated Transcription Regulation Of DNA-templated Transcription Apoptotic Process Nervous System Development Heart Development Muscle Organ Development Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of D-glucose Import Mitochondrion Distribution Animal Organ Development Dendrite Morphogenesis Ventricular Cardiac Myofibril Assembly Cardiac Conduction ERK5 Cascade Cellular Response To Calcium Ion	Negative Regulation Of Transcription By RNA Polymerase II Noradrenergic Neuron Development Noradrenergic Neuron Fate Commitment Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Regulation Of Mitotic Cell Cycle Pattern Specification Process Nervous System Development Neuroblast Fate Determination Neuroblast Proliferation Sensory Organ Development Heart Development Regulation Of Notch Signaling Pathway Regulation Of Gene Expression Oligodendrocyte Development Spinal Cord Association Neuron Differentiation Spinal Cord Oligodendrocyte Cell Differentiation Spinal Cord Oligodendrocyte Cell Fate Specification Vestibular Nucleus Development Oligodendrocyte Cell Fate Commitment Forebrain Neuron Differentiation Cerebral Cortex GABAergic Interneuron Differentiation Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Central Nervous System Neuron Development Cerebral Cortex Development Neurogenesis Cell Differentiation Neuron Differentiation Regulation Of Epithelial Cell Differentiation Response To Retinoic Acid Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Sympathetic Nervous System Development Neuron Fate Commitment Neuron Fate Specification Neuron Development Generation Of Neurons Oligodendrocyte Differentiation Peripheral Nervous System Neuron Development Regulation Of Neurogenesis Positive Regulation Of Neurogenesis Musculoskeletal Movement, Spinal Reflex Action Response To Folic Acid Subpallium Neuron Fate Commitment Regulation Of Timing Of Subpallium Neuron Differentiation Olfactory Pit Development Lung Epithelial Cell Differentiation Ventral Spinal Cord Interneuron Fate Commitment Lung Neuroendocrine Cell Differentiation Neuroendocrine Cell Differentiation Stomach Neuroendocrine Cell Differentiation Carotid Body Glomus Cell Differentiation Adrenal Chromaffin Cell Differentiation Neural Precursor Cell Proliferation Sympathetic Ganglion Development Response To Epidermal Growth Factor Cellular Response To Magnetism GABAergic Neuron Differentiation Motor Neuron Migration Positive Regulation Of Neural Precursor Cell Proliferation
Pathways		ERK/MAPK targets Myogenesis	NGF-stimulated transcription NGF-stimulated transcription
Drugs
Diseases			Congenital central hypoventilation syndrome (CCHS)
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Cervical cancer ( 28806749) Dental caries (decayed and filled deciduous teeth) ( 31533690) Gestational age at birth (maternal effect) ( 28598419) Systolic blood pressure ( 30224653 30578418)	C-reactive protein levels ( 21300955 30388399) Menopause (age at onset) ( 26414677) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259)
Interacting Genes		30 interacting genes: ACTN4 ASCL1 CASP3 CASP7 CDK5 DDB1 DNMT3L EP300 ERBIN GABARAPL2 HAND1 HDAC4 HDAC5 HDAC7 HDAC9 HSF2BP MAPK14 MAPK7 MEF2D MEOX1 MYOD1 MYOG NDUFB9 PHB2 SMAD2 SMAD4 SUMO1 TEAD1 THRA VGLL4	13 interacting genes: BMP2 EP300 HUNK MEF2A MEF2C MEF2D MTNR1A NEUROG2 RSPH1 TCF4 UBQLN1 UBQLN2 USP20
Entrez ID		4205	429
HPRD ID		02807	00011
Ensembl ID		ENSG00000068305	ENSG00000139352
Uniprot IDs		A0A0S2Z417 A0A0S2Z453 A0A0S2Z454 A0A0S2Z4C8 A0A0S2Z4N0 A0A8I5KVQ4 A8K720 Q02078	P50553
PDB IDs		1C7U 1EGW 1LEW 3KOV 3MU6 3P57 6BYY 6BZ1 7XUZ
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Cellular Developmental Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Cell Differentiation Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Myotube Differentiation Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Macromolecule Metabolic Process Developmental Process Nucleus Positive Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Macromolecule Biosynthetic Process Animal Organ Development Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Protein Lysine Deacetylase Activity Positive Regulation Of Biosynthetic Process Regulation Of Muscle Cell Differentiation DNA-binding Transcription Factor Activity Positive Regulation Of RNA Metabolic Process Heart Development Cell Fate Commitment DNA-binding Transcription Factor Binding Histone Deacetylase Activity Positive Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity Skeletal Muscle Tissue Development Striated Muscle Tissue Development Nucleoplasm Chromatin Striated Muscle Cell Differentiation	System Development Nervous System Development Protein Dimerization Activity Heart Development DNA-binding Transcription Factor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Cardiac Chamber Formation Positive Regulation Of Neuron Differentiation Autophagosome Assembly Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Autophagosome Organization Positive Regulation Of ERAD Pathway Regulation Of Cardiac Muscle Cell Differentiation Muscle Organ Development Positive Regulation Of RNA Metabolic Process Platelet Formation Regulation Of Autophagy Histone Deacetylase Binding Muscle Structure Development Regulation Of ERAD Pathway Regulation Of Smooth Muscle Cell Proliferation Muscle Tissue Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process Vacuole Organization Cardiac Muscle Cell Differentiation Animal Organ Development Cellular Developmental Process Regulation Of Neuron Differentiation Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Bone Mineralization Positive Regulation Of Ossification Cell Differentiation Cardiocyte Differentiation Positive Regulation Of Biomineral Tissue Development Negative Regulation Of Calcium-independent Cell-cell Adhesion Regulation Of Transport Transcription Regulator Complex Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity
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