HIST2H3A and DNTTIP2

Number of citations of the paper that reports this interaction (PMID 12786946)
3

Data Source:
BioGRID (pull down)

		HIST2H3A	DNTTIP2
Gene Name		histone cluster 2, H3a	deoxynucleotidyltransferase, terminal, interacting protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleosome Extracellular Region Nucleus Nucleoplasm Extracellular Vesicular Exosome	Nucleus Nucleolus
	Molecular Function	DNA Binding Protein Binding Protein Heterodimerization Activity	Poly(A) RNA Binding
	Biological Process	Chromatin Silencing At RDNA Blood Coagulation Gene Expression DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression Factors involved in megakaryocyte development and platelet production PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: CBX5 DNTTIP2 EHMT2 GTF3C4 HDAC9 ING1 KDM5A KDM5C LALBA MECP2 PADI4 PRDM1 PRMT6 SETDB1 SUV39H1 UHRF1	11 interactors: DNTT ESR1 ESR2 HIST1H2BA HIST2H3A HIST3H2A HIST4H4 PCNA PPARG RXRA SPP1
Entrez ID		333932	30836
HPRD ID			09994
Ensembl ID
Uniprot IDs		Q71DI3	Q5QJE6
PDB IDs		2IIJ 2X4W 2X4X 2X4Y 3AV1 3DB3 3MO8 3QO2 3R93
Enriched GO Terms of Interacting Partners?		Chromatin Modification Chromatin Organization Histone Modification Chromosome Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Methylation Regulation Of RNA Metabolic Process Histone H3-K9 Modification Negative Regulation Of Cellular Metabolic Process Peptidyl-lysine Modification Histone Methylation Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Organelle Organization RNA Metabolic Process Peptidyl-amino Acid Modification Protein Methylation Gene Expression Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone H3-K9 Methylation Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Protein Modification Process Regulation Of Gene Expression, Epigenetic Histone H3-K9 Trimethylation Histone Lysine Methylation Peptidyl-lysine Dimethylation DNA Methylation On Cytosine Peptidyl-lysine Methylation Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Metabolic Process Peptidyl-lysine Trimethylation Chromatin Silencing Regulation Of Cellular Process	Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Developmental Process Involved In Reproduction Nucleobase-containing Compound Metabolic Process Response To Lipid Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Steroid Hormone Intracellular Receptor Signaling Pathway Reproductive Structure Development Cellular Nitrogen Compound Metabolic Process Reproductive System Development Epithelial Cell Differentiation Peroxisome Proliferator Activated Receptor Signaling Pathway DNA-templated Transcription, Initiation DNA Metabolic Process Prostate Gland Development Nitrogen Compound Metabolic Process Single Organism Reproductive Process Regulation Of Branching Involved In Prostate Gland Morphogenesis Maternal Process Involved In Female Pregnancy DNA Modification Reproductive Process Negative Regulation Of Gene Expression DNA Methylation On Cytosine Vagina Development Multicellular Organismal Reproductive Process Uterus Development Multicellular Organism Reproduction Nucleosome Disassembly Cellular Response To Organic Cyclic Compound Chromatin Silencing At RDNA Response To Organic Cyclic Compound Cellular Response To Lipid Intracellular Estrogen Receptor Signaling Pathway Epithelial Cell Differentiation Involved In Prostate Gland Development Nucleosome Organization Response To Hormone Female Genitalia Development Negative Regulation Of Cell Growth Chromatin Assembly Or Disassembly Tissue Development Chromosome Organization Reproduction Epithelium Development Chromatin Remodeling Negative Regulation Of Transcription, DNA-templated Placenta Development
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