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HIST2H3A and MECP2
Number of citations of the paper that reports this interaction (PMID
12427740
)
165
Data Source:
BioGRID
(pull down)
HIST2H3A
MECP2
Gene Name
histone cluster 2, H3a
methyl CpG binding protein 2
Image
Gene Ontology Annotations
Cellular Component
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Extracellular Vesicular Exosome
Heterochromatin
Extracellular Space
Nucleus
Nucleoplasm
Cytosol
Molecular Function
DNA Binding
Protein Binding
Protein Heterodimerization Activity
DNA Binding
Chromatin Binding
Sequence-specific DNA Binding Transcription Factor Activity
Transcription Corepressor Activity
MRNA Binding
Protein Binding
Transcription Factor Binding
Methyl-CpG Binding
Double-stranded Methylated DNA Binding
Protein Domain Specific Binding
SiRNA Binding
Poly(A) RNA Binding
Protein N-terminus Binding
Biological Process
Chromatin Silencing At RDNA
Blood Coagulation
Gene Expression
DNA Methylation On Cytosine
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Behavioral Fear Response
Response To Hypoxia
Startle Response
Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure
Regulation Of Respiratory Gaseous Exchange By Neurological System Process
Inositol Metabolic Process
Mitochondrial Electron Transport, Ubiquinol To Cytochrome C
Chromatin Silencing
Regulation Of Gene Expression By Genetic Imprinting
Transcription, DNA-templated
Glutamine Metabolic Process
Synapse Assembly
Respiratory Gaseous Exchange
Long-term Memory
Protein Localization
Glucocorticoid Metabolic Process
Positive Regulation Of Cell Proliferation
Adult Locomotory Behavior
Visual Learning
Pathogenesis
Post-embryonic Development
Dendrite Development
Histone Methylation
Histone Acetylation
Proprioception
Sensory Perception Of Pain
Cerebellum Development
Ventricular System Development
Negative Regulation Of Histone Methylation
Cardiolipin Metabolic Process
Negative Regulation Of Histone Acetylation
Social Behavior
Neuron Maturation
Negative Regulation Of Neuron Apoptotic Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Phosphatidylcholine Metabolic Process
Catecholamine Secretion
Positive Regulation Of Synapse Assembly
Regulation Of Excitatory Postsynaptic Membrane Potential
Long-term Synaptic Potentiation
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
PKMTs methylate histone lysines
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
HDMs demethylate histones
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
Factors involved in megakaryocyte development and platelet production
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Red blood cell traits (
23446634
)
Protein-Protein Interactions
16 interactors:
CBX5
DNTTIP2
EHMT2
GTF3C4
HDAC9
ING1
KDM5A
KDM5C
LALBA
MECP2
PADI4
PRDM1
PRMT6
SETDB1
SUV39H1
UHRF1
17 interactors:
DNMT1
GTF2B
HDAC1
HIPK2
HIST2H3A
HMGB1
LBR
NCOR1
PRPF40A
PRPF40B
RNF4
SIN3A
SKI
SMARCA2
SMARCB1
SOX18
SPI1
Entrez ID
333932
4204
HPRD ID
02050
Ensembl ID
ENSG00000169057
Uniprot IDs
Q71DI3
D3YJ43
P51608
Q59FJ6
PDB IDs
2IIJ
2X4W
2X4X
2X4Y
3AV1
3DB3
3MO8
3QO2
3R93
1QK9
3C2I
Enriched GO Terms of Interacting Partners
?
Chromatin Modification
Chromatin Organization
Histone Modification
Chromosome Organization
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Methylation
Regulation Of RNA Metabolic Process
Histone H3-K9 Modification
Negative Regulation Of Cellular Metabolic Process
Peptidyl-lysine Modification
Histone Methylation
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Organelle Organization
RNA Metabolic Process
Peptidyl-amino Acid Modification
Protein Methylation
Gene Expression
Cellular Macromolecule Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Macromolecule Biosynthetic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Histone H3-K9 Methylation
Biosynthetic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
Cellular Protein Modification Process
Regulation Of Gene Expression, Epigenetic
Histone H3-K9 Trimethylation
Histone Lysine Methylation
Peptidyl-lysine Dimethylation
DNA Methylation On Cytosine
Peptidyl-lysine Methylation
Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Protein Metabolic Process
Peptidyl-lysine Trimethylation
Chromatin Silencing
Regulation Of Cellular Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Gene Expression
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Nitrogen Compound Metabolic Process
RNA Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Gene Expression
Nitrogen Compound Metabolic Process
Negative Regulation Of Gene Expression, Epigenetic
Transcription, DNA-templated
Chromatin Modification
Positive Regulation Of Transcription, DNA-templated
RNA Biosynthetic Process
Regulation Of Chromosome Organization
Positive Regulation Of Cellular Metabolic Process
Chromatin Organization
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of Cellular Metabolic Process
Regulation Of RNA Biosynthetic Process
Regulation Of Histone Modification
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of RNA Metabolic Process
Transcription From RNA Polymerase II Promoter
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Chromosome Organization
Positive Regulation Of Metabolic Process
Regulation Of Gene Expression, Epigenetic
Regulation Of DNA Binding
Cellular Macromolecule Biosynthetic Process
Negative Regulation Of Chromosome Organization
Macromolecule Biosynthetic Process
Biosynthetic Process
Regulation Of Cellular Component Organization
Positive Regulation Of DNA Binding
Transforming Growth Factor Beta Receptor Signaling Pathway
Transcription Initiation From RNA Polymerase II Promoter
Chromatin Remodeling
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Transforming Growth Factor Beta
Tagcloud
?
ache
ahr
antimirs
arguing
cholinergic
cns
correlates
creb
detrusor
ep300
influences
jarid1a
limits
micrornas
mimics
mir
mirna
mirnas
nuclei
obstruction
outlet
outside
plasticity
pnkd
referenced
synapse
transfection
unrelated
urethra
Tagcloud (Difference)
?
ache
ahr
antimirs
arguing
cholinergic
cns
correlates
creb
detrusor
ep300
influences
jarid1a
limits
micrornas
mimics
mir
mirna
mirnas
nuclei
obstruction
outlet
outside
plasticity
pnkd
referenced
synapse
transfection
unrelated
urethra
Tagcloud (Intersection)
?