HIST2H3A and PADI4

Number of citations of the paper that reports this interaction (PMID 15339660)
130

Data Source:
BioGRID (enzymatic study)

		HIST2H3A	PADI4
Gene Name		histone cluster 2, H3a	peptidyl arginine deiminase, type IV
Image
Gene Ontology Annotations	Cellular Component	Nucleosome Extracellular Region Nucleus Nucleoplasm Extracellular Vesicular Exosome	Nucleus Cytoplasm
	Molecular Function	DNA Binding Protein Binding Protein Heterodimerization Activity	Protein-arginine Deiminase Activity Calcium Ion Binding Protein Binding Arginine Deiminase Activity
	Biological Process	Chromatin Silencing At RDNA Blood Coagulation Gene Expression DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic	Nucleosome Assembly Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Protein Modification Process Chromatin Modification Protein Citrullination Stem Cell Maintenance Histone H3-R26 Citrullination Histone Citrullination Innate Immune Response
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression Factors involved in megakaryocyte development and platelet production PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs			L-Citrulline N-[(1S)-1-(AMINOCARBONYL)-4-(ETHANIMIDOYLAMINO)BUTYL]BENZAMIDE
Diseases
GWAS			Basal cell carcinoma ( 18849993) Rheumatoid arthritis ( 21452313 21505073)
Protein-Protein Interactions		16 interactors: CBX5 DNTTIP2 EHMT2 GTF3C4 HDAC9 ING1 KDM5A KDM5C LALBA MECP2 PADI4 PRDM1 PRMT6 SETDB1 SUV39H1 UHRF1	6 interactors: ANXA4 APP FBXO25 HDAC2 HIST2H3A NPM1
Entrez ID		333932	23569
HPRD ID			05635
Ensembl ID			ENSG00000159339
Uniprot IDs		Q71DI3	B2RBW0 Q9UM07
PDB IDs		2IIJ 2X4W 2X4X 2X4Y 3AV1 3DB3 3MO8 3QO2 3R93	1WD8 1WD9 1WDA 2DEW 2DEX 2DEY 2DW5 3APM 3APN 3B1T 3B1U 4DKT
Enriched GO Terms of Interacting Partners?		Chromatin Modification Chromatin Organization Histone Modification Chromosome Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Methylation Regulation Of RNA Metabolic Process Histone H3-K9 Modification Negative Regulation Of Cellular Metabolic Process Peptidyl-lysine Modification Histone Methylation Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Organelle Organization RNA Metabolic Process Peptidyl-amino Acid Modification Protein Methylation Gene Expression Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone H3-K9 Methylation Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Protein Modification Process Regulation Of Gene Expression, Epigenetic Histone H3-K9 Trimethylation Histone Lysine Methylation Peptidyl-lysine Dimethylation DNA Methylation On Cytosine Peptidyl-lysine Methylation Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Metabolic Process Peptidyl-lysine Trimethylation Chromatin Silencing Regulation Of Cellular Process	Chromatin Silencing Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Blood Coagulation Hemostasis ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA Regulation Of Body Fluid Levels Gene Silencing Wound Healing Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Wounding Dendrite Development Synaptic Growth At Neuromuscular Junction Negative Regulation Of Catalytic Activity Collateral Sprouting In Absence Of Injury Maintenance Of Chromatin Silencing Regulation Of Ribonuclease Activity Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Cellular Metabolic Process Chromatin Remodeling Negative Regulation Of Neuron Differentiation Negative Regulation Of Interleukin-8 Secretion Regulation Of Transcription, DNA-templated Negative Regulation Of Apoptotic Process Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Programmed Cell Death Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Gene Expression, Epigenetic Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of RNA Metabolic Process Negative Regulation Of Cell Death Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Negative Regulation Of MHC Class II Biosynthetic Process Axon Choice Point Recognition Fungiform Papilla Formation Negative Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Gene Expression Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Translation Regulation Of Nitrogen Compound Metabolic Process Regulation Of Developmental Growth Negative Regulation Of Neurogenesis Positive Regulation Of Proteolysis Fungiform Papilla Morphogenesis
Tagcloud ?			arginine barr carm1 centre compelling continuing deiminase dissect ebv epstein gc germinal hl hodgkin latent lmp1 lymphomagenesis methyltransferases modulated next precursors presumptive prmt prmt1 prmt5 reed stably sternberg transforming
Tagcloud (Difference) ?			arginine barr carm1 centre compelling continuing deiminase dissect ebv epstein gc germinal hl hodgkin latent lmp1 lymphomagenesis methyltransferases modulated next precursors presumptive prmt prmt1 prmt5 reed stably sternberg transforming
Tagcloud (Intersection) ?