HIST2H3A and KDM5A

Number of citations of the paper that reports this interaction (PMID 17320161)
120

Data Source:
BioGRID (pull down)

		HIST2H3A	KDM5A
Gene Name		histone cluster 2, H3a	lysine (K)-specific demethylase 5A
Image
Gene Ontology Annotations	Cellular Component	Nucleosome Extracellular Region Nucleus Nucleoplasm Extracellular Vesicular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Cyclin-dependent Protein Kinase Activating Kinase Holoenzyme Complex
	Molecular Function	DNA Binding Protein Binding Protein Heterodimerization Activity	DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Zinc Ion Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors
	Biological Process	Chromatin Silencing At RDNA Blood Coagulation Gene Expression DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic	Chromatin Organization Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Chromatin Modification Circadian Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Oxidation-reduction Process Negative Regulation Of Histone Deacetylase Activity
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression Factors involved in megakaryocyte development and platelet production PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes	Chromatin modifying enzymes Chromatin organization HDMs demethylate histones
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: CBX5 DNTTIP2 EHMT2 GTF3C4 HDAC9 ING1 KDM5A KDM5C LALBA MECP2 PADI4 PRDM1 PRMT6 SETDB1 SUV39H1 UHRF1	10 interactors: ESR1 HIST2H3A HIST3H3 LMO2 NR3C1 RARA RB1 RBL1 TBP VDR
Entrez ID		333932	5927
HPRD ID			08915
Ensembl ID			ENSG00000073614
Uniprot IDs		Q71DI3	P29375
PDB IDs		2IIJ 2X4W 2X4X 2X4Y 3AV1 3DB3 3MO8 3QO2 3R93	2JXJ 2KGG 2KGI 3GL6
Enriched GO Terms of Interacting Partners?		Chromatin Modification Chromatin Organization Histone Modification Chromosome Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Methylation Regulation Of RNA Metabolic Process Histone H3-K9 Modification Negative Regulation Of Cellular Metabolic Process Peptidyl-lysine Modification Histone Methylation Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Organelle Organization RNA Metabolic Process Peptidyl-amino Acid Modification Protein Methylation Gene Expression Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone H3-K9 Methylation Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Protein Modification Process Regulation Of Gene Expression, Epigenetic Histone H3-K9 Trimethylation Histone Lysine Methylation Peptidyl-lysine Dimethylation DNA Methylation On Cytosine Peptidyl-lysine Methylation Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Metabolic Process Peptidyl-lysine Trimethylation Chromatin Silencing Regulation Of Cellular Process	Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Positive Regulation Of Transcription, DNA-templated Intracellular Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Steroid Hormone Mediated Signaling Pathway Regulation Of Lipid Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Gene Expression Hormone-mediated Signaling Pathway Cellular Nitrogen Compound Metabolic Process Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Nitrogen Compound Metabolic Process Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Cellular Metabolic Process Mammary Gland Branching Involved In Pregnancy Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Lipid Kinase Activity Mammary Gland Duct Morphogenesis Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Response To Hormone Stimulus Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Mammary Gland Morphogenesis Tube Development Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Mammary Gland Epithelium Development Multicellular Organismal Reproductive Process Cellular Macromolecule Biosynthetic Process Multicellular Organism Reproduction Macromolecule Biosynthetic Process Epithelial Tube Morphogenesis Cellular Response To Organic Cyclic Compound
Tagcloud ?			blast blastic bp called cml demethylase demethylating downregulated epigenetically fatal h3k4 inhibits jarid1a leukemia locus lysine mir myeloid pdcd4 poorly rbp2 responds stimulates transformation treatments trimethylated turn underexpressed usually
Tagcloud (Difference) ?			blast blastic bp called cml demethylase demethylating downregulated epigenetically fatal h3k4 inhibits jarid1a leukemia locus lysine mir myeloid pdcd4 poorly rbp2 responds stimulates transformation treatments trimethylated turn underexpressed usually
Tagcloud (Intersection) ?