H3C15

Description		H3 clustered histone 15
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GO Annotations	Cellular Component	Chromatin Nucleosome Extracellular Region Nucleus Nucleoplasm Chromosome Extracellular Exosome
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Nucleosome Assembly Gene Expression
Pathways		Interleukin-7 signaling Interleukin-7 signaling Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) HDACs deacetylate histones PKMTs methylate histone lysines HDMs demethylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines Chromatin modifying enzymes SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Assembly of the ORC complex at the origin of replication RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Factors involved in megakaryocyte development and platelet production MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS
Interacting Genes		17 interacting genes: ANP32A CBX5 DNTTIP2 EHMT2 GTF3C4 HDAC9 KDM5A KDM5C LALBA MECP2 PADI4 PRDM1 PRMT6 SETDB1 SUV39H1 UBR7 UHRF1
Entrez ID		333932
HPRD ID
Ensembl ID		ENSG00000203852
Uniprot IDs		Q71DI3
PDB IDs		2IIJ 2X4W 2X4X 2X4Y 3AV1 3DB3 3MO8 3QO2 3R93 4MZF 4MZG 4MZH 4OUC 5B0Y 5B0Z 5B40 5BO0 5CIU 5VAC 6ACE 6FML 6T79 6T7A 6T7B 6T7C 6T7D 6X59 6X5A 6XJD 6Y5D 6Y5E 7BQZ 7BU9 7JO9 7JOA 7JZV 7PET 7PEU 7PEV 7PEW 7PEX 7PEY 7PEZ 7PF0 7PF2 7PF3 7PF4 7PF5 7PF6 7PFA 7PFC 7PFD 7PFE 7PFF 7PFT 7PFU 7PFV 7PFW 7PFX 7TAN 7U50 7U51 7U52 7U53 7UV9 7UVA 7XCR 7XCT 7XD0 7YRD 8AAG 8ATF 8AV6 8GRQ 8HQY 8HR1 8JLB 8JLD 8OL1 8VMJ 8VMN 8VO0 8VOB 8VWS 8VWT 8VWU 8VWV 8X7I 8X7J 8X7K 9DWF 9DWG 9DWH 9DWI 9DWJ 9DWK 9DWL 9DWM 9GMK 9GMR 9IPU
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromatin Organization Negative Regulation Of Gene Expression, Epigenetic Heterochromatin Formation Epigenetic Regulation Of Gene Expression Histone H3 Methyltransferase Activity Nucleoplasm Histone Methyltransferase Activity Histone H3K9me2 Methyltransferase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Histone H3K9 Methyltransferase Activity Negative Regulation Of RNA Metabolic Process Heterochromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Methyltransferase Activity Promoter-specific Chromatin Binding Negative Regulation Of Macromolecule Biosynthetic Process Methylation Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Chromatin Binding Histone H3K9 Trimethyltransferase Activity Negative Regulation Of Metabolic Process Histone H3K4me/H3K4me2/H3K4me3 Demethylase Activity Nucleus Histone Binding Histone H3K4 Demethylase Activity Facultative Heterochromatin Formation Transferase Activity Metal Ion Binding Histone H3K9me2/3 Reader Activity Histone Demethylase Activity Nucleolus Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Response To Stress Regulation Of RNA Biosynthetic Process Zinc Ion Binding Histone Reader Activity Methyl-CpG Binding Histone Methyltransferase Complex Chromosome Regulation Of RNA Metabolic Process Epigenetic Programming Of Gene Expression DNA Methylation-dependent Constitutive Heterochromatin Formation Histone Deacetylase Complex
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