DYRK2

Name	dual specificity tyrosine phosphorylation regulated kinase 2
Structure
Interactors	23 interactors: APP ATM DYRK4 EIF2B5 FBXW7 H2BC21 H3-4 IKZF1 KATNA1 KXD1 LRRK2 LZTS2 MAPT MDM2 NR1I2 RAD54B SIAH2 SP100 TERT UBE2D1 UBR5 WDR62 ZBTB9
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Protein-containing Complex Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Manganese Ion Binding Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation Apoptotic Process DNA Damage Response Smoothened Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Signal Transduction By P53 Class Mediator
Pathways	Regulation of TP53 Activity through Phosphorylation
GWAS	Amyotrophic lateral sclerosis (C9orf72 mutation interaction) ( 22959728 ) Daytime sleep phenotypes ( 27126917 ) Itch intensity from mosquito bite ( 28199695 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Malaria ( 31844061 ) Metabolite levels ( 23823483 ) Mosquito bite size ( 28199695 ) Peak height velocity ( 34047840 ) Systemic lupus erythematosus ( 28714469 )
Entrez ID	8445
HPRD ID	04606
Ensembl ID	ENSG00000127334
Uniprot IDs	Q92630
PDB IDs	3K2L 3KVW 4AZF 5LXC 5LXD 5ZTN 6HDP 6HDR 6K0J 7AKF 7AKH 7DG4 7DH3 7DH9 7DHC 7DHH 7DHK 7DHN 7DHO 7DHV 7DJO 7DL6 8HLT
GO Terms Enriched among Interactors ?	Amyloid Fibril Formation Regulation Of Apoptotic Signaling Pathway Regulation Of Protein Localization Regulation Of Wnt Signaling Pathway Regulation Of Establishment Of Protein Localization Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Nucleus Negative Regulation Of Cell Communication Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Determination Of Adult Lifespan Cellular Response To Reactive Oxygen Species Regulation Of Canonical Wnt Signaling Pathway Main Axon Cellular Response To Stress DNA Binding Proteasomal Protein Catabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Negative Regulation Of Biosynthetic Process Cellular Response To Manganese Ion Regulation Of Protein Localization To Nucleus Regulation Of Cellular Response To Stress Identical Protein Binding Response To Reactive Oxygen Species DNA Damage Response DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Distribution Of Mitochondria Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Microtubule Severing Response To Metal Ion Regulation Of Programmed Cell Death Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Chromosome, Telomeric Region Response To Oxidative Stress Positive Regulation Of Neuron Apoptotic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Stability Protein Ubiquitination Regulation Of Protein Ubiquitination Protein Catabolic Process Positive Regulation Of Proteolysis Response To Manganese Ion Regulation Of Gene Expression Positive Regulation Of Protein Catabolic Process Cellular Response To Oxidative Stress Regulation Of Signal Transduction Replicative Senescence