DYRK2 and DYRK4

Number of citations of the paper that reports this interaction (PMID 23602568)
8

Data Source:
BioGRID (affinity chromatography technology, fluorescent resonance energy transfer, affinity chromatography technology)

		DYRK2	DYRK4
Gene Name		dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Ribonucleoprotein Complex	Nucleus Cytoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Manganese Ion Binding Ubiquitin Binding	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Protein Phosphorylation Cellular Response To DNA Damage Stimulus Smoothened Signaling Pathway Peptidyl-tyrosine Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Glycogen Biosynthetic Process Negative Regulation Of NFAT Protein Import Into Nucleus	Peptidyl-tyrosine Phosphorylation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: APP ATM DDB1 DYRK4 HIST2H2BE HIST3H3 IKZF1 KATNA1 KXD1 LZTS2 MDM2 NR1I2 RAD54B SIAH2 SP100 TERT UBC UBR5 WDR62 ZBTB9	6 interactors: CUL3 DYRK2 FBXO25 MID1 NEDD4 PPP1CC
Entrez ID		8445	8798
HPRD ID		04606	10926
Ensembl ID			ENSG00000010219
Uniprot IDs		Q92630	B4E1A4 D3JEN2 Q9NR20
PDB IDs		3K2L 3KVW 4AZF
Enriched GO Terms of Interacting Partners?		Telomere Maintenance Intracellular Receptor Signaling Pathway DNA Damage Response, Signal Transduction By P53 Class Mediator Chromosome Organization Regulation Of Mitotic Cell Cycle Phase Transition Signal Transduction In Response To DNA Damage DNA Metabolic Process Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cellular Metabolic Process Signal Transduction By P53 Class Mediator Cellular Response To DNA Damage Stimulus Regulation Of Wnt Signaling Pathway Cell Cycle Protein Catabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Mitotic Cell Cycle Chromatin Organization Mitotic G1 DNA Damage Checkpoint Replicative Senescence Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Arrest Microtubule Severing Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Arrest Mitotic DNA Damage Checkpoint Proteolysis Involved In Cellular Protein Catabolic Process Organelle Organization Positive Regulation Of Cell Cycle Cellular Protein Catabolic Process Protein Ubiquitination Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Repair Chromatin Modification Protein Modification By Small Protein Conjugation	Protein Monoubiquitination Cell Surface Receptor Signaling Pathway Cellular Protein Modification Process Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Protein Ubiquitination Negative Regulation Of Cellular Response To Growth Factor Stimulus Protein Modification By Small Protein Conjugation Catabolic Process Depurination Trophectodermal Cellular Morphogenesis Protein Polyubiquitination Cellular Macromolecule Catabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Intrinsic Apoptotic Signaling Pathway Cellular Protein Metabolic Process Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation Positive Regulation Of Protein Catabolic Process Progesterone Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage DNA Dealkylation Involved In DNA Repair Negative Regulation Of Signal Transduction Base-excision Repair, AP Site Formation Positive Regulation Of Mitotic Metaphase/anaphase Transition Protein Localization To Microtubule Glucocorticoid Receptor Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of NFAT Protein Import Into Nucleus Regulation Of Signal Transduction Signal Transduction Response To Light Stimulus Protein Targeting To Lysosome Apoptotic Signaling Pathway Embryonic Cleavage Negative Regulation Of Sodium Ion Transport Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Metabolic Process Positive Regulation Of Glycogen Biosynthetic Process Regulation Of Signaling Protein Localization To Lysosome Stress Fiber Assembly Signaling Regulation Of Protein Catabolic Process Negative Regulation Of Transport Cell Communication Positive Regulation Of Chromosome Segregation Deoxyribose Phosphate Catabolic Process Cellular Response To Stress
Tagcloud ?		better clinicopathological closely december dual free grade histological hormone hundred ihc immunohistochemical involvement january lymph metastasis node predict predictive prognosis recurrence seventy specificity stage status surgery ten underwent
Tagcloud (Difference) ?		better clinicopathological closely december dual free grade histological hormone hundred ihc immunohistochemical involvement january lymph metastasis node predict predictive prognosis recurrence seventy specificity stage status surgery ten underwent
Tagcloud (Intersection) ?