DYRK2 and UBR5

Number of citations of the paper that reports this interaction (PubMedID 32707033)
104

Data Source:
BioGRID (affinity chromatography technology, proximity labelling technology, affinity chromatography technology, affinity chromatography technology, pull down)

		DYRK2	UBR5
Description		dual specificity tyrosine phosphorylation regulated kinase 2	ubiquitin protein ligase E3 component n-recognin 5
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Protein-containing Complex Ribonucleoprotein Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Manganese Ion Binding Protein Serine Kinase Activity	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Phosphorylation Apoptotic Process DNA Damage Response Smoothened Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Signal Transduction By P53 Class Mediator	Protein Polyubiquitination DNA Repair DNA Damage Response Response To Oxidative Stress Proteasomal Protein Catabolic Process Positive Regulation Of Gene Expression Protein Ubiquitination Estrogen Receptor Signaling Pathway Heterochromatin Boundary Formation Protein K29-linked Ubiquitination Positive Regulation Of Protein Import Into Nucleus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Smoothened Signaling Pathway Retinoic Acid Receptor Signaling Pathway Progesterone Receptor Signaling Pathway Vitamin D Receptor Signaling Pathway Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Nuclear Protein Quality Control By The Ubiquitin-proteasome System Positive Regulation Of Canonical Wnt Signaling Pathway Cytoplasm Protein Quality Control DNA Repair-dependent Chromatin Remodeling Protein Branched Polyubiquitination
Pathways		Regulation of TP53 Activity through Phosphorylation
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (C9orf72 mutation interaction) ( 22959728) Daytime sleep phenotypes ( 27126917) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Malaria ( 31844061) Metabolite levels ( 23823483) Mosquito bite size ( 28199695) Peak height velocity ( 34047840) Systemic lupus erythematosus ( 28714469)	Chromosomal aberration frequency (total) ( 31586183) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Rate of cognitive decline in mild cognitive impairment (time interaction) ( 22833209) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		23 interacting genes: APP ATM DYRK4 EIF2B5 FBXW7 H2BC21 H3-4 IKZF1 KATNA1 KXD1 LRRK2 LZTS2 MAPT MDM2 NR1I2 RAD54B SIAH2 SP100 TERT UBE2D1 UBR5 WDR62 ZBTB9	53 interacting genes: ACSL4 AKIRIN2 ATF3 BARD1 CDC20 CEBPA CIB1 CIP2A CSPP1 DYRK2 ERG ESR1 GSK3B INO80C KPNA1 KPNA2 KPNB1 MAPK1 MOAP1 MYC NFIL3 NR1I2 NR3C1 NRL OTUD5 PAIP1 PAIP2 PCK1 PGR PPP1CA PTTG1 RARA RUVBL2 RXRA SATB1 SMAD2 SMARCB1 SOX2 STIP1 TCEA1 TOPBP1 TXNIP UBE2A UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2J1 UBE2L3 UBE3A VDR
Entrez ID		8445	51366
HPRD ID		04606	06436
Ensembl ID		ENSG00000127334	ENSG00000104517
Uniprot IDs		Q92630	O95071
PDB IDs		3K2L 3KVW 4AZF 5LXC 5LXD 5ZTN 6HDP 6HDR 6K0J 7AKF 7AKH 7DG4 7DH3 7DH9 7DHC 7DHH 7DHK 7DHN 7DHO 7DHV 7DJO 7DL6 8HLT	1I2T 2QHO 3PT3 8BJA 8C06 8C07 8D4X 8E0Q 8EWI 8P82 8P83
Enriched GO Terms of Interacting Partners?		Amyloid Fibril Formation Regulation Of Apoptotic Signaling Pathway Regulation Of Protein Localization Regulation Of Wnt Signaling Pathway Regulation Of Establishment Of Protein Localization Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Nucleus Negative Regulation Of Cell Communication Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Determination Of Adult Lifespan Cellular Response To Reactive Oxygen Species Regulation Of Canonical Wnt Signaling Pathway Main Axon Cellular Response To Stress DNA Binding Proteasomal Protein Catabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Negative Regulation Of Biosynthetic Process Cellular Response To Manganese Ion Regulation Of Protein Localization To Nucleus Regulation Of Cellular Response To Stress Identical Protein Binding Response To Reactive Oxygen Species DNA Damage Response DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Distribution Of Mitochondria Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Microtubule Severing Response To Metal Ion Regulation Of Programmed Cell Death Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Chromosome, Telomeric Region Response To Oxidative Stress Positive Regulation Of Neuron Apoptotic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Stability Protein Ubiquitination Regulation Of Protein Ubiquitination Protein Catabolic Process Positive Regulation Of Proteolysis Response To Manganese Ion Regulation Of Gene Expression Positive Regulation Of Protein Catabolic Process Cellular Response To Oxidative Stress Regulation Of Signal Transduction Replicative Senescence	Positive Regulation Of Metabolic Process Ubiquitin Conjugating Enzyme Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Nucleus Chromatin Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process DNA-binding Transcription Factor Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Nuclear Receptor Activity Negative Regulation Of Macromolecule Metabolic Process Protein Polyubiquitination Response To Lipid Protein K48-linked Ubiquitination Negative Regulation Of RNA Metabolic Process Cellular Response To Stress RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Metabolic Process Ubiquitin-protein Transferase Activity DNA Damage Response Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Developmental Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Modification Process Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Proteolysis
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