DYRK2 and UBR5

Number of citations of the paper that reports this interaction (PMID 19287380)
32

Data Source:
BioGRID (affinity chromatography technology, pull down)

		DYRK2	UBR5
Gene Name		dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	ubiquitin protein ligase E3 component n-recognin 5
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Membrane
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Manganese Ion Binding Ubiquitin Binding	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Binding
	Biological Process	Protein Phosphorylation Cellular Response To DNA Damage Stimulus Smoothened Signaling Pathway Peptidyl-tyrosine Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Glycogen Biosynthetic Process Negative Regulation Of NFAT Protein Import Into Nucleus	Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Cell Proliferation Positive Regulation Of Protein Import Into Nucleus, Translocation Positive Regulation Of Catenin Import Into Nucleus Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Progesterone Receptor Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Histone H2A K63-linked Ubiquitination Negative Regulation Of Double-strand Break Repair
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: APP ATM DDB1 DYRK4 HIST2H2BE HIST3H3 IKZF1 KATNA1 KXD1 LZTS2 MDM2 NR1I2 RAD54B SIAH2 SP100 TERT UBC UBR5 WDR62 ZBTB9	23 interactors: BARD1 CIB1 DYRK2 GSK3B KPNA1 KPNA2 KPNB1 MAPK1 NR1I2 PAIP1 PAIP2 PGR SATB1 SMAD2 TCEA1 TOPBP1 TP53 UBC UBE2A UBE2B UBE2D2 UBE2D3 UBE2L3
Entrez ID		8445	51366
HPRD ID		04606	06436
Ensembl ID			ENSG00000104517
Uniprot IDs		Q92630	E7EMW7 O95071
PDB IDs		3K2L 3KVW 4AZF	1I2T 2QHO 3PT3
Enriched GO Terms of Interacting Partners?		Telomere Maintenance Intracellular Receptor Signaling Pathway DNA Damage Response, Signal Transduction By P53 Class Mediator Chromosome Organization Regulation Of Mitotic Cell Cycle Phase Transition Signal Transduction In Response To DNA Damage DNA Metabolic Process Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cellular Metabolic Process Signal Transduction By P53 Class Mediator Cellular Response To DNA Damage Stimulus Regulation Of Wnt Signaling Pathway Cell Cycle Protein Catabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Mitotic Cell Cycle Chromatin Organization Mitotic G1 DNA Damage Checkpoint Replicative Senescence Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Arrest Microtubule Severing Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Arrest Mitotic DNA Damage Checkpoint Proteolysis Involved In Cellular Protein Catabolic Process Organelle Organization Positive Regulation Of Cell Cycle Cellular Protein Catabolic Process Protein Ubiquitination Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Repair Chromatin Modification Protein Modification By Small Protein Conjugation	Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Response To Organic Substance Nitrogen Compound Metabolic Process Cellular Response To Stress Protein Polyubiquitination DNA Repair Cellular Response To Stimulus Protein K11-linked Ubiquitination Response To Organic Substance Apoptotic Process Programmed Cell Death Cell Death Death Response To Stimulus Viral Process Cellular Macromolecule Catabolic Process Protein K48-linked Ubiquitination Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Protein Import Into Nucleus Nuclear Import Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Nucleocytoplasmic Transport Regulation Of Intracellular Transport Nuclear Transport Negative Regulation Of Gene Expression Protein Import Positive Regulation Of Metabolic Process Response To Abiotic Stimulus TRIF-dependent Toll-like Receptor Signaling Pathway Protein Localization To Nucleus Positive Regulation Of Macromolecule Biosynthetic Process MyD88-independent Toll-like Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Toll-like Receptor 3 Signaling Pathway Cellular Response To Growth Factor Stimulus Protein Ubiquitination Cellular Response To Cytokine Stimulus Positive Regulation Of Cellular Biosynthetic Process Transcription From RNA Polymerase II Promoter Response To Growth Factor NLS-bearing Protein Import Into Nucleus Toll-like Receptor 4 Signaling Pathway
Tagcloud ?		better clinicopathological closely december dual free grade histological hormone hundred ihc immunohistochemical involvement january lymph metastasis node predict predictive prognosis recurrence seventy specificity stage status surgery ten underwent	aberrations abt achilles atm aurora birc3 bruton continues descending driver engagement exploited give heel ibrutinib impressive lethal mantle mcl microenvironment nevertheless noncanonical notch1 recurrently ribose sox traf2 underscored vulnerabilities
Tagcloud (Difference) ?		better clinicopathological closely december dual free grade histological hormone hundred ihc immunohistochemical involvement january lymph metastasis node predict predictive prognosis recurrence seventy specificity stage status surgery ten underwent	aberrations abt achilles atm aurora birc3 bruton continues descending driver engagement exploited give heel ibrutinib impressive lethal mantle mcl microenvironment nevertheless noncanonical notch1 recurrently ribose sox traf2 underscored vulnerabilities
Tagcloud (Intersection) ?