ESCO2 and MCM5

Number of citations of the paper that reports this interaction (PubMedID 30100344)
0

Data Source:
BioGRID (pull down)

		ESCO2	MCM5
Description		establishment of sister chromatid cohesion N-acetyltransferase 2	minichromosome maintenance complex component 5
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin XY Body Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin Golgi Apparatus Chromocenter Cell Junction Site Of Double-strand Break	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Membrane MCM Complex CMG Complex
	Molecular Function	L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Protein Binding N-acetyltransferase Activity Zinc Ion Binding Acetyltransferase Activity Transferase Activity Acyltransferase Activity Metal Ion Binding Protein-lysine-acetyltransferase Activity	Nucleotide Binding DNA Binding DNA Replication Origin Binding Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity 3'-5' DNA Helicase Activity
	Biological Process	Hematopoietic Progenitor Cell Differentiation Regulation Of DNA Replication Double-strand Break Repair Chromosome Segregation Sister Chromatid Cohesion Mitotic Sister Chromatid Cohesion Post-translational Protein Acetylation Protein Localization To Chromatin	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Regulation Of DNA-templated DNA Replication Initiation
Pathways		Establishment of Sister Chromatid Cohesion	Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence
Drugs
Diseases		ESCO2-related disorders, including: Roberts syndrome; SC phocomelia syndrome
GWAS			Chronotype ( 30696823) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		12 interacting genes: FXR1 GOLGA2 MCM2 MCM4 MCM5 MCM6 MCM7 MMS22L PCNA PICK1 RABEP1 SMC3	30 interacting genes: APP ATRIP CDC5L CDC7 CDKN2A CEBPA EP300 ESCO2 FBXO7 KRTAP10-7 LMNA MCM2 MCM3 MCM7 MCMBP MCPH1 MDFI NFKBIA NUDT3 ORC1 ORC2 ORC3 ORC5 ORC6 PTEN RBPMS RPA2 STAT1 TRIM28 YWHAG
Entrez ID		157570	4174
HPRD ID		18564	04075
Ensembl ID		ENSG00000171320	ENSG00000100297
Uniprot IDs		Q56NI9	B1AHB0 P33992
PDB IDs			6XTX 6XTY 7PFO 7PLO 7W1Y 7W68 8B9D 8S09 8S0A 8S0B 8S0D 8S0E 8S0F 8W0E 8W0F 8W0G 8W0I 9CAQ
Enriched GO Terms of Interacting Partners?		MCM Complex CMG Complex Double-strand Break Repair Via Break-induced Replication Regulation Of DNA-templated DNA Replication Initiation Regulation Of DNA Replication DNA Replication Initiation Single-stranded DNA Binding Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Repair DNA Replication Single-stranded DNA Helicase Activity Chromosome, Telomeric Region Double-strand Break Repair DNA Metabolic Process DNA Recombination DNA Damage Response DNA Helicase Activity Regulation Of DNA Metabolic Process Helicase Activity Cellular Response To Stress ATP Hydrolysis Activity DNA Strand Elongation Involved In DNA Replication Chromosome DNA Strand Elongation Mitotic DNA Replication Initiation Nucleic Acid Metabolic Process Response To Stress 3'-5' DNA Helicase Activity DNA Replication Origin Binding Nucleobase-containing Compound Metabolic Process Nuclear Replication Fork Macromolecule Metabolic Process ATP Binding DNA Binding Replication Fork Processing Mitotic Spindle Assembly Nucleotide Binding PCNA Complex Replisome Membraneless Organelle Assembly Cellular Response To Xenobiotic Stimulus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Receptor Internalization PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Nucleoplasm Mitotic Spindle Organization	DNA Replication Initiation Nuclear Origin Of Replication Recognition Complex DNA Replication Origin Recognition Complex DNA Metabolic Process Nucleoplasm Nucleic Acid Metabolic Process DNA Replication Origin Binding Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA Metabolic Process Chromosome, Telomeric Region Regulation Of DNA Replication Nucleobase-containing Compound Metabolic Process MCM Complex Double-strand Break Repair Via Break-induced Replication Regulation Of Primary Metabolic Process Cellular Response To Stress Macromolecule Metabolic Process Response To Stress Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle DNA Repair Regulation Of Protein Localization To Nucleus DNA Damage Response Regulation Of Cell Cycle Phase Transition CMG Complex Regulation Of Cell Cycle Chromatin Double-strand Break Repair Negative Regulation Of Cell Cycle Phase Transition Regulation Of DNA-templated DNA Replication Initiation Regulation Of Cell Cycle Process DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination Single-stranded DNA Helicase Activity Recombinational Repair Negative Regulation Of Cell Cycle Process Protein Localization To Organelle Mitotic DNA Replication Initiation Identical Protein Binding Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Intracellular Signal Transduction NF-kappaB Binding Regulation Of Protein Stability Single-stranded DNA Binding Negative Regulation Of DNA-templated Transcription
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