ESCO2 and MMS22L

Number of citations of the paper that reports this interaction (PubMedID 30779731)
54

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ESCO2	MMS22L
Description		establishment of sister chromatid cohesion N-acetyltransferase 2	MMS22 like, DNA repair protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin XY Body Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin Golgi Apparatus Chromocenter Cell Junction Site Of Double-strand Break	Nucleus Nucleoplasm Chromosome Cytosol FACT Complex Site Of Double-strand Break MCM Complex Nuclear Replication Fork Site Of DNA Damage
	Molecular Function	L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Protein Binding N-acetyltransferase Activity Zinc Ion Binding Acetyltransferase Activity Transferase Activity Acyltransferase Activity Metal Ion Binding Protein-lysine-acetyltransferase Activity	DNA Binding Single-stranded DNA Binding Protein Binding
	Biological Process	Hematopoietic Progenitor Cell Differentiation Regulation Of DNA Replication Double-strand Break Repair Chromosome Segregation Sister Chromatid Cohesion Mitotic Sister Chromatid Cohesion Post-translational Protein Acetylation Protein Localization To Chromatin	Double-strand Break Repair Via Homologous Recombination DNA Repair Chromatin Organization DNA Damage Response Replication Fork Processing Protein Localization To Chromatin
Pathways		Establishment of Sister Chromatid Cohesion
Drugs
Diseases		ESCO2-related disorders, including: Roberts syndrome; SC phocomelia syndrome
GWAS			Adult body size ( 32376654) Anxiety ( 33859377) Automobile speeding propensity ( 30643258) Body mass index ( 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Chronotype ( 30696823) Gut microbiota (bacterial taxa) ( 27694959) Hand grip strength ( 29691431) Morning person ( 30696823) Multiple sclerosis (OCB status) ( 23785401) Number of sexual partners ( 30643258) Photic sneeze reflex ( 27182965) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)
Interacting Genes		12 interacting genes: FXR1 GOLGA2 MCM2 MCM4 MCM5 MCM6 MCM7 MMS22L PCNA PICK1 RABEP1 SMC3	4 interacting genes: ESCO2 FBXW7 RAD51 RPA1
Entrez ID		157570	253714
HPRD ID		18564	12865
Ensembl ID		ENSG00000171320	ENSG00000146263
Uniprot IDs		Q56NI9	E2QRD4 Q6ZRQ5
PDB IDs
Enriched GO Terms of Interacting Partners?		MCM Complex CMG Complex Double-strand Break Repair Via Break-induced Replication Regulation Of DNA-templated DNA Replication Initiation Regulation Of DNA Replication DNA Replication Initiation Single-stranded DNA Binding Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Repair DNA Replication Single-stranded DNA Helicase Activity Chromosome, Telomeric Region Double-strand Break Repair DNA Metabolic Process DNA Recombination DNA Damage Response DNA Helicase Activity Regulation Of DNA Metabolic Process Helicase Activity Cellular Response To Stress ATP Hydrolysis Activity DNA Strand Elongation Involved In DNA Replication Chromosome DNA Strand Elongation Mitotic DNA Replication Initiation Nucleic Acid Metabolic Process Response To Stress 3'-5' DNA Helicase Activity DNA Replication Origin Binding Nucleobase-containing Compound Metabolic Process Nuclear Replication Fork Macromolecule Metabolic Process ATP Binding DNA Binding Replication Fork Processing Mitotic Spindle Assembly Nucleotide Binding PCNA Complex Replisome Membraneless Organelle Assembly Cellular Response To Xenobiotic Stimulus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Receptor Internalization PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Nucleoplasm Mitotic Spindle Organization	Lateral Element Site Of Double-strand Break Chromosome Organization Telomere Maintenance Via Telomere Lengthening Nuclear Chromosome Positive Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Negative Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Cellular Response To Stress Condensed Chromosome Response To Glucoside Double-strand Break Repair Condensed Nuclear Chromosome DNA Repair Male Germ Cell Nucleus Negative Regulation Of Establishment Of Blood-brain Barrier Sister Chromatid Cohesion Positive Regulation Of Translational Initiation In Response To Stress Response To Unfolded Protein Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress Mitotic Recombination-dependent Replication Fork Processing DNA Metabolic Process DNA Damage Response DNA Strand Exchange Activity Regulation Of Double-strand Break Repair Via Homologous Recombination Presynaptic Intermediate Filament Cytoskeleton Regulation Of Establishment Of Blood-brain Barrier Vitamin E Binding Dendritic Transport Of Mitochondrion Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Negative Regulation Of Hepatocyte Proliferation Phosphothreonine Residue Binding Arginyl-tRNA Aminoacylation Arginine-tRNA Ligase Activity Post-translational Protein Acetylation Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Meiotic Cell Cycle DNA Strand Invasion Telomere Maintenance Single-stranded DNA Binding DNA Recombinase Assembly Cellular Response To Cisplatin Cellular Response To Camptothecin Response To Toxic Substance PML Body Single-stranded Telomeric DNA Binding Protein Localization To Chromosome Vitamin E Metabolic Process Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Ubiquitin Recycling
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