ESCO2

Description		establishment of sister chromatid cohesion N-acetyltransferase 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin XY Body Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin Golgi Apparatus Chromocenter Cell Junction Site Of Double-strand Break
	Molecular Function	L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Protein Binding N-acetyltransferase Activity Zinc Ion Binding Acetyltransferase Activity Transferase Activity Acyltransferase Activity Metal Ion Binding Protein-lysine-acetyltransferase Activity
	Biological Process	Hematopoietic Progenitor Cell Differentiation Regulation Of DNA Replication Double-strand Break Repair Chromosome Segregation Sister Chromatid Cohesion Mitotic Sister Chromatid Cohesion Post-translational Protein Acetylation Protein Localization To Chromatin
Pathways		Establishment of Sister Chromatid Cohesion
Drugs
Diseases		ESCO2-related disorders, including: Roberts syndrome; SC phocomelia syndrome
GWAS
Interacting Genes		12 interacting genes: FXR1 GOLGA2 MCM2 MCM4 MCM5 MCM6 MCM7 MMS22L PCNA PICK1 RABEP1 SMC3
Entrez ID		157570
HPRD ID		18564
Ensembl ID		ENSG00000171320
Uniprot IDs		Q56NI9
PDB IDs
Enriched GO Terms of Interacting Partners?		MCM Complex CMG Complex Double-strand Break Repair Via Break-induced Replication Regulation Of DNA-templated DNA Replication Initiation Regulation Of DNA Replication DNA Replication Initiation Single-stranded DNA Binding Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Repair DNA Replication Single-stranded DNA Helicase Activity Chromosome, Telomeric Region Double-strand Break Repair DNA Metabolic Process DNA Recombination DNA Damage Response DNA Helicase Activity Regulation Of DNA Metabolic Process Helicase Activity Cellular Response To Stress ATP Hydrolysis Activity DNA Strand Elongation Involved In DNA Replication Chromosome DNA Strand Elongation Mitotic DNA Replication Initiation Nucleic Acid Metabolic Process Response To Stress 3'-5' DNA Helicase Activity DNA Replication Origin Binding Nucleobase-containing Compound Metabolic Process Nuclear Replication Fork Macromolecule Metabolic Process ATP Binding DNA Binding Replication Fork Processing Mitotic Spindle Assembly Nucleotide Binding PCNA Complex Replisome Membraneless Organelle Assembly Cellular Response To Xenobiotic Stimulus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Receptor Internalization PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Nucleoplasm Mitotic Spindle Organization
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