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MCL1 and PCNA
Number of citations of the paper that reports this interaction (PubMedID
15554878
)
32
Data Source:
BioGRID
(two hybrid, affinity chromatography technology)
HPRD
(in vivo, two hybrid, in vitro)
MCL1
PCNA
Description
MCL1 apoptosis regulator, BCL2 family member
proliferating cell nuclear antigen
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Cytosol
Membrane
Bcl-2 Family Protein Complex
Cyclin-dependent Protein Kinase Holoenzyme Complex
Chromosome, Telomeric Region
Chromatin
Male Germ Cell Nucleus
Nucleus
Nuclear Lamina
Nucleoplasm
Replication Fork
Centrosome
Nuclear Body
Replisome
Nuclear Replication Fork
PCNA Complex
Extracellular Exosome
PCNA-p21 Complex
Molecular Function
Protein Binding
Protein Transmembrane Transporter Activity
Channel Activity
Protein Heterodimerization Activity
BH Domain Binding
BH3 Domain Binding
Purine-specific Mismatch Base Pair DNA N-glycosylase Activity
DNA Binding
Chromatin Binding
Damaged DNA Binding
Protein Binding
Enzyme Binding
Nuclear Estrogen Receptor Binding
DNA Polymerase Processivity Factor Activity
Receptor Tyrosine Kinase Binding
Dinucleotide Insertion Or Deletion Binding
MutLalpha Complex Binding
Histone Acetyltransferase Binding
Identical Protein Binding
Protein-containing Complex Binding
DNA Polymerase Binding
Biological Process
Cell Fate Determination
Release Of Cytochrome C From Mitochondria
Apoptotic Process
DNA Damage Response
Mitochondrial Fusion
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Negative Regulation Of Autophagy
Cellular Homeostasis
Cell Differentiation
Response To Cytokine
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Transmembrane Transport
Protein Transmembrane Transport
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Anoikis
Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Negative Regulation Of Transcription By RNA Polymerase II
DNA Replication
Leading Strand Elongation
Regulation Of DNA Replication
DNA Repair
Base-excision Repair, Gap-filling
Mismatch Repair
Chromatin Organization
DNA Damage Response
Response To Oxidative Stress
Heart Development
Translesion Synthesis
Epithelial Cell Differentiation
Replication Fork Processing
Positive Regulation Of Deoxyribonuclease Activity
Response To Estradiol
Response To Lipid
Cellular Response To UV
Estrous Cycle
Positive Regulation Of DNA Repair
Positive Regulation Of DNA Replication
Response To Cadmium Ion
Cellular Response To Hydrogen Peroxide
Cellular Response To Xenobiotic Stimulus
Response To Dexamethasone
Liver Regeneration
Positive Regulation Of DNA-directed DNA Polymerase Activity
Response To L-glutamate
Mitotic Telomere Maintenance Via Semi-conservative Replication
Pathways
Interleukin-4 and Interleukin-13 signaling
Signaling by ALK fusions and activated point mutants
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Transcription of E2F targets under negative control by DREAM complex
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Removal of the Flap Intermediate from the C-strand
SUMOylation of DNA replication proteins
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand
G1/S-Specific Transcription
E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Liothyronine
Acetylsalicylic acid
Diseases
GWAS
Blood protein levels (
30072576
)
Coffee consumption (
31959922
)
Coronary artery disease (
29212778
)
Eosinophil count (
27863252
)
FEV1 (
30804560
)
Lung function (FEV1) (
26635082
)
Lung function (FVC) (
26635082
30804560
)
Mean corpuscular hemoglobin (
32888494
)
Melanoma (
21983785
)
Monocyte count (
29403010
)
Multiple sclerosis (
31604244
)
Refractive error (
32231278
)
Rhegmatogenous retinal detachment (
23585552
)
Sum eosinophil basophil counts (
27863252
)
White matter hyperintensity volume (
33293549
)
White matter hyperintensity volume (adjusted for hypertension) (
33293549
)
White matter hyperintensity volume x hypertension interaction (2df) (
33293549
)
Interacting Genes
40 interacting genes:
APEX1
BAD
BAK1
BAX
BBC3
BCL2L1
BCL2L11
BID
BIK
BMF
BOK
BTRC
CASP3
CDC20
CHRM4
DAD1
FBXW11
GSK3A
GSK3B
HIF1A
HRK
HUWE1
KCNF1
MAPK1
MAPK10
PCNA
PIN1
PMAIP1
SIRT1
SIRT2
SIRT3
STX8
TNKS
TPT1
TRAF6
TRIM11
UBXN6
UHRF2
USP9X
VDAC1
142 interacting genes:
ALDOA
APEX1
APEX2
ATAD5
ATM
BAZ1B
CBX1
CCNB1
CCND1
CCND3
CCNO
CDC25C
CDC6
CDK1
CDK2
CDK5
CDK6
CDKN1A
CDKN1C
CDKN2A
CDT1
CHAF1A
CHTF18
CHTF8
CMTM5
CREBBP
DHX9
DNMT1
DNTT
DNTTIP2
DSCC1
DTL
EGFR
ENO1
EP300
ERCC5
ERCC6
ERRFI1
ESCO2
EXO1
FAN1
FANCD2
FANCL
FBH1
FEN1
GADD45A
GADD45B
GADD45G
GAPDH
GCK
GPI
HDAC1
HUS1
ING1
KCTD13
KMT5A
LDHA
LIG1
MCL1
MGMT
MLH1
MLH3
MSH2
MSH3
MSH6
MTOR
MUTYH
MYBBP1A
NEDD8
NIPBL
NMRAL1
NSD2
NTHL1
NUTF2
PARP1
PARP10
PARPBP
PCLAF
PFKM
PGAM1
PGK1
PKLR
PMS2
POLB
POLD1
POLD2
POLD3
POLD4
POLDIP2
POLE
POLH
POLI
POLK
POLL
POLM
PPP1CA
PRKDC
PTEN
PTMA
RAD18
RAD9A
RBBP8
RECQL5
RFC1
RFC2
RFC3
RFC4
RFC5
RFWD3
RPA1
S100A8
SDE2
SEC23IP
SIVA1
SLC30A8
SMARCAD1
SPG21
SUB1
SUMO1
TCOF1
TDG
TIRAP
TMEM218
TPI1
UBB
UBC
UBE2A
UBE2B
UBE2D3
UBE2I
UBE3D
UHRF1
UNG
USP4
WDR48
WRN
XPA
XRCC1
XRCC5
XRCC6
YBX1
ZBTB1
Entrez ID
4170
5111
HPRD ID
08870
01456
Ensembl ID
ENSG00000143384
ENSG00000132646
Uniprot IDs
A0A087WT64
C8YZ26
Q07820
P12004
PDB IDs
2KBW
2MHS
2NL9
2NLA
2PQK
3D7V
3IO9
3KJ0
3KJ1
3KJ2
3KZ0
3MK8
3PK1
3TWU
3WIX
3WIY
4BPI
4BPJ
4HW2
4HW3
4HW4
4OQ5
4OQ6
4WGI
4WMR
4WMS
4WMT
4WMU
4WMV
4WMW
4WMX
4ZBF
4ZBI
5C3F
5C6H
5FC4
5FDO
5FDR
5IEZ
5IF4
5JSB
5KU9
5LOF
5MES
5MEV
5UUM
5VKC
5VX2
5W89
5W8F
6B4L
6B4U
6BW2
6BW8
6FS0
6FS1
6FS2
6MBD
6MBE
6NE5
6O4U
6O6F
6O6G
6OQB
6OQC
6OQD
6OQN
6OVC
6P3P
6QB3
6QB4
6QB6
6QFC
6QFI
6QFM
6QFQ
6QGD
6QXJ
6QYK
6QYL
6QYN
6QYO
6QYP
6QZ5
6QZ6
6QZ7
6QZ8
6QZB
6STJ
6U63
6U64
6U65
6U67
6U6F
6UA3
6UAB
6UD2
6UDI
6UDT
6UDU
6UDV
6UDX
6UDY
6VBX
6YBG
6YBJ
6YBK
6YBL
6ZIE
7NB4
7NB7
7XGE
8AV9
8EKX
8EL0
8EL1
8G3S
8G3T
8G3U
8G3W
8G3X
8G3Y
8H7B
8IQM
8QSO
8SVY
8T6F
8VJP
8Y1Y
8Y1Z
8Y20
9BCG
9CKN
1AXC
1U76
1U7B
1UL1
1VYJ
1VYM
1W60
2ZVK
2ZVL
2ZVM
3JA9
3P87
3TBL
3VKX
3WGW
4D2G
4RJF
4ZTD
5E0T
5E0U
5E0V
5IY4
5MAV
5MLO
5MLW
5MOM
5YCO
5YD8
6CBI
6EHT
6FCM
6FCN
6GIS
6GWS
6HVO
6K3A
6QC0
6QCG
6S1M
6S1N
6S1O
6TNY
6TNZ
6VVO
7EFA
7KQ0
7KQ1
7M5L
7M5M
7M5N
7NV0
7NV1
7QNZ
7QO1
8B8T
8COB
8E84
8F5Q
8GCJ
8GL9
8GLA
8UI7
8UI8
8UI9
8UII
8UMT
8UMU
8UMV
8UMW
8UMY
8UN0
8YJH
8YJL
8YJQ
8YJR
8YJS
8YJU
8YJV
8YJW
8YJZ
9B8S
9B8T
9CG4
9CHM
9CL7
9CMA
9EOA
9F6D
9F6E
9F6F
9GY0
Enriched GO Terms of Interacting Partners
?
Regulation Of Mitochondrion Organization
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Regulation Of Release Of Cytochrome C From Mitochondria
Regulation Of Mitochondrial Membrane Permeability
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Release Of Cytochrome C From Mitochondria
Apoptotic Mitochondrial Changes
Regulation Of Membrane Permeability
Regulation Of Apoptotic Process
Positive Regulation Of Organelle Organization
Regulation Of Programmed Cell Death
Regulation Of Organelle Organization
Cellular Response To Stress
Bcl-2 Family Protein Complex
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Apoptotic Signaling Pathway
Apoptotic Process
Programmed Cell Death
Cell Death
Mitochondrial Membrane Organization
Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Mitochondrial Membrane Permeability
Regulation Of Intrinsic Apoptotic Signaling Pathway
Mitochondrion Organization
Positive Regulation Of Membrane Permeability
DNA Damage Response
Mitochondrial Outer Membrane
Regulation Of Autophagy
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Response To Endoplasmic Reticulum Stress
Intrinsic Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Cell Communication
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signaling
Regulation Of Cellular Response To Stress
Regulation Of Neuron Apoptotic Process
Mitochondrion
Leukocyte Apoptotic Process
Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Regulation Of Response To Endoplasmic Reticulum Stress
Response To Stress
Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response
Positive Regulation Of Signal Transduction
Organelle Organization
Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Cellular Component Organization
DNA Damage Response
DNA Repair
DNA Metabolic Process
Cellular Response To Stress
Nucleobase-containing Compound Metabolic Process
Nucleic Acid Metabolic Process
Nucleus
Nucleoplasm
Response To Stress
DNA Replication
DNA Recombination
Macromolecule Metabolic Process
Damaged DNA Binding
Double-strand Break Repair
DNA Biosynthetic Process
Regulation Of DNA Metabolic Process
Response To Radiation
DNA Binding
Postreplication Repair
Response To UV
Positive Regulation Of DNA Metabolic Process
DNA Synthesis Involved In DNA Repair
Recombinational Repair
Base-excision Repair
Chromosome Organization
DNA-templated DNA Replication
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Double-strand Break Repair Via Homologous Recombination
Mismatch Repair
DNA-directed DNA Polymerase Activity
Response To Light Stimulus
Translesion Synthesis
Somatic Hypermutation Of Immunoglobulin Genes
Regulation Of DNA Recombination
Negative Regulation Of Metabolic Process
DNA Clamp Loader Activity
Somatic Diversification Of Immune Receptors Via Somatic Mutation
Regulation Of Cell Cycle Phase Transition
Nucleobase-containing Compound Biosynthetic Process
Regulation Of Primary Metabolic Process
Mitotic DNA Integrity Checkpoint Signaling
Somatic Diversification Of Immunoglobulins
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Cell Cycle Process
Negative Regulation Of DNA Metabolic Process
DNA Polymerase Activity
Somatic Cell DNA Recombination
Ctf18 RFC-like Complex
Glycolytic Process
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Tagcloud (Intersection)
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