MCL1 and BAX

Number of citations of the paper that reports this interaction (PubMedID 10837489)
0

Data Source:
HPRD (in vitro)

		MCL1	BAX
Description		MCL1 apoptosis regulator, BCL2 family member	BCL2 associated X, apoptosis regulator
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Bcl-2 Family Protein Complex	Nucleus Nuclear Envelope Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Permeability Transition Pore Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Mitochondrial Membrane Pore Complex Extracellular Exosome Cell Periphery Bcl-2 Family Protein Complex BAX Complex BAK Complex
	Molecular Function	Protein Binding Protein Transmembrane Transporter Activity Channel Activity Protein Heterodimerization Activity BH Domain Binding BH3 Domain Binding	Protein Binding Lipid Binding Channel Activity Hsp70 Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein-folding Chaperone Binding BH3 Domain Binding
	Biological Process	Cell Fate Determination Release Of Cytochrome C From Mitochondria Apoptotic Process DNA Damage Response Mitochondrial Fusion Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Autophagy Cellular Homeostasis Cell Differentiation Response To Cytokine Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Transmembrane Transport Protein Transmembrane Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Intracellular Signal Transduction Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Anoikis Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Ovarian Follicle Development Neuron Migration Leukocyte Homeostasis T Cell Homeostatic Proliferation B Cell Homeostasis B Cell Apoptotic Process Kidney Development Release Of Cytochrome C From Mitochondria Blood Vessel Remodeling Myeloid Cell Homeostasis B Cell Negative Selection B Cell Homeostatic Proliferation Positive Regulation Of B Cell Apoptotic Process Glycosphingolipid Metabolic Process Regulation Of Nitrogen Utilization Apoptotic Process DNA Damage Response Mitochondrion Organization Germ Cell Development Spermatogenesis Nervous System Development Sex Differentiation Mitochondrial Fusion Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Apoptotic Mitochondrial Changes Fertilization Response To Wounding Response To Toxic Substance Response To Salt Stress Post-embryonic Development Response To Ionizing Radiation Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Response To Gamma Radiation Positive Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Mitochondrial Membrane Potential Hypothalamus Development Cerebral Cortex Development Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Protein Binding Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Release Of Matrix Enzymes From Mitochondria Cellular Response To Stress Regulation Of Mammary Gland Epithelial Cell Proliferation Cellular Response To Unfolded Protein Cellular Response To UV Limb Morphogenesis Ectopic Germ Cell Programmed Cell Death Odontogenesis Of Dentin-containing Tooth Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Mitochondrial Fragmentation Involved In Apoptotic Process Development Of Secondary Sexual Characteristics Retinal Cell Programmed Cell Death Positive Regulation Of Developmental Pigmentation Negative Regulation Of Fibroblast Proliferation Spermatid Differentiation Post-embryonic Camera-type Eye Morphogenesis Response To Axon Injury Homeostasis Of Number Of Cells Homeostasis Of Number Of Cells Within A Tissue Epithelial Cell Proliferation Positive Regulation Of Developmental Process Protein Insertion Into Mitochondrial Membrane Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Neuron Apoptotic Process Establishment Of Localization In Cell Regulation Of Cell Cycle Regulation Of Mitochondrial Membrane Potential Sertoli Cell Proliferation Retina Development In Camera-type Eye Apoptotic Process Involved In Mammary Gland Involution Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Vagina Development Calcium Ion Transport Into Cytosol Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Thymocyte Apoptotic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Release Of Cytochrome C From Mitochondria Motor Neuron Apoptotic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Supramolecular Fiber Organization Cellular Response To Virus Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Apoptotic Process Involved In Blood Vessel Morphogenesis Apoptotic Process Involved In Embryonic Digit Morphogenesis Regulation Of Mitochondrial Membrane Permeability Involved In Programmed Necrotic Cell Death Positive Regulation Of Apoptotic DNA Fragmentation Regulation Of Intracellular Signal Transduction Positive Regulation Of IRE1-mediated Unfolded Protein Response Epithelial Cell Apoptotic Process Positive Regulation Of Epithelial Cell Apoptotic Process B Cell Receptor Apoptotic Signaling Pathway Positive Regulation Of Reproductive Process Positive Regulation Of Motor Neuron Apoptotic Process Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Interleukin-4 and Interleukin-13 signaling Signaling by ALK fusions and activated point mutants	Release of apoptotic factors from the mitochondria Activation, translocation and oligomerization of BAX Pyroptosis TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Transcriptional regulation by RUNX2 NTRK3 as a dependence receptor
Drugs			TAK-901
Diseases			Colorectal cancer
GWAS		Blood protein levels ( 30072576) Coffee consumption ( 31959922) Coronary artery disease ( 29212778) Eosinophil count ( 27863252) FEV1 ( 30804560) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 26635082 30804560) Mean corpuscular hemoglobin ( 32888494) Melanoma ( 21983785) Monocyte count ( 29403010) Multiple sclerosis ( 31604244) Refractive error ( 32231278) Rhegmatogenous retinal detachment ( 23585552) Sum eosinophil basophil counts ( 27863252) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Asthma ( 27611488) Eosinophil count ( 27863252 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Plateletcrit ( 32888494) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494)
Interacting Genes		40 interacting genes: APEX1 BAD BAK1 BAX BBC3 BCL2L1 BCL2L11 BID BIK BMF BOK BTRC CASP3 CDC20 CHRM4 DAD1 FBXW11 GSK3A GSK3B HIF1A HRK HUWE1 KCNF1 MAPK1 MAPK10 PCNA PIN1 PMAIP1 SIRT1 SIRT2 SIRT3 STX8 TNKS TPT1 TRAF6 TRIM11 UBXN6 UHRF2 USP9X VDAC1	30 interacting genes: ANP32B BAK1 BBC3 BCL2 BCL2A1 BCL2L1 BCL2L10 BID ERN1 FBXL20 HSF2BP KCNA3 LEF1 MAP2K1 MCL1 MOAP1 NOL3 PARK7 PMAIP1 PPP1CA SFN SH3GLB1 SLC25A4 TRIM17 UHRF2 USP12 VDAC1 YWHAB YWHAQ ZBTB24
Entrez ID		4170	581
HPRD ID		08870	02498
Ensembl ID		ENSG00000143384	ENSG00000087088
Uniprot IDs		A0A087WT64 C8YZ26 Q07820	I6LPK7 Q07812 Q5ZPJ0 Q5ZPJ1
PDB IDs		2KBW 2MHS 2NL9 2NLA 2PQK 3D7V 3IO9 3KJ0 3KJ1 3KJ2 3KZ0 3MK8 3PK1 3TWU 3WIX 3WIY 4BPI 4BPJ 4HW2 4HW3 4HW4 4OQ5 4OQ6 4WGI 4WMR 4WMS 4WMT 4WMU 4WMV 4WMW 4WMX 4ZBF 4ZBI 5C3F 5C6H 5FC4 5FDO 5FDR 5IEZ 5IF4 5JSB 5KU9 5LOF 5MES 5MEV 5UUM 5VKC 5VX2 5W89 5W8F 6B4L 6B4U 6BW2 6BW8 6FS0 6FS1 6FS2 6MBD 6MBE 6NE5 6O4U 6O6F 6O6G 6OQB 6OQC 6OQD 6OQN 6OVC 6P3P 6QB3 6QB4 6QB6 6QFC 6QFI 6QFM 6QFQ 6QGD 6QXJ 6QYK 6QYL 6QYN 6QYO 6QYP 6QZ5 6QZ6 6QZ7 6QZ8 6QZB 6STJ 6U63 6U64 6U65 6U67 6U6F 6UA3 6UAB 6UD2 6UDI 6UDT 6UDU 6UDV 6UDX 6UDY 6VBX 6YBG 6YBJ 6YBK 6YBL 6ZIE 7NB4 7NB7 7XGE 8AV9 8EKX 8EL0 8EL1 8G3S 8G3T 8G3U 8G3W 8G3X 8G3Y 8H7B 8IQM 8QSO 8SVY 8T6F 8VJP 8Y1Y 8Y1Z 8Y20 9BCG 9CKN	1F16 2G5B 2K7W 2LR1 3PK1 3PL7 4BD2 4BD6 4BD7 4BD8 4BDU 4S0O 4S0P 4UF2 4ZIE 4ZIF 4ZIG 4ZIH 4ZII 5W5X 5W5Z 5W60 5W61 6EB6 6L8V 6L95 6TRR 6XY6 7ADT 8G1T 8SPE 8SPF 8SPZ 8SRX 8SRY 8SVK
Enriched GO Terms of Interacting Partners?		Regulation Of Mitochondrion Organization Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Release Of Cytochrome C From Mitochondria Apoptotic Mitochondrial Changes Regulation Of Membrane Permeability Regulation Of Apoptotic Process Positive Regulation Of Organelle Organization Regulation Of Programmed Cell Death Regulation Of Organelle Organization Cellular Response To Stress Bcl-2 Family Protein Complex Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Cell Death Mitochondrial Membrane Organization Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Membrane Permeability Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrion Organization Positive Regulation Of Membrane Permeability DNA Damage Response Mitochondrial Outer Membrane Regulation Of Autophagy Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Cellular Response To Stress Regulation Of Neuron Apoptotic Process Mitochondrion Leukocyte Apoptotic Process Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress Response To Stress Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Signal Transduction Organelle Organization Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Cellular Component Organization	Release Of Cytochrome C From Mitochondria Apoptotic Mitochondrial Changes Mitochondrion Organization Intrinsic Apoptotic Signaling Pathway Mitochondrial Outer Membrane Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Apoptotic Process Regulation Of Apoptotic Signaling Pathway Bcl-2 Family Protein Complex Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Programmed Cell Death Cell Death DNA Damage Response Mitochondrial Membrane Organization Regulation Of Mitochondrion Organization Extrinsic Apoptotic Signaling Pathway Regulation Of Membrane Permeability Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Channel Activity Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Autophagy Positive Regulation Of Release Of Cytochrome C From Mitochondria Response To Stress Cellular Response To Stress Mitochondrion Regulation Of Mitochondrial Membrane Potential Intracellular Signal Transduction Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Cellular Response To Stress Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Membrane Permeability Positive Regulation Of Intrinsic Apoptotic Signaling Pathway BH3 Domain Binding Organelle Organization Positive Regulation Of Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Autophagy Mitochondrial Membrane
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