CHST6 and NUP214

Data Source: HiPPIP (Novel)

		CHST6	NUP214
Name		carbohydrate sulfotransferase 6	nucleoporin 214
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Trans-Golgi Network Membrane	Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytosol Cytoplasmic Side Of Nuclear Pore
	Molecular Function	N-acetylglucosamine 6-O-sulfotransferase Activity Sulfotransferase Activity Transferase Activity Keratan Sulfotransferase Activity	Nuclear Export Signal Receptor Activity Protein Binding Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore
	Biological Process	Carbohydrate Metabolic Process N-acetylglucosamine Metabolic Process Sulfur Compound Metabolic Process Keratan Sulfate Proteoglycan Biosynthetic Process	RNA Export From Nucleus MRNA Export From Nucleus Protein Import Into Nucleus Protein Export From Nucleus Intracellular Protein Transport Nucleocytoplasmic Transport Protein Transport Regulation Of Nucleocytoplasmic Transport MRNA Transport Regulation Of Cell Cycle
Pathways		Keratan sulfate biosynthesis Defective CHST6 causes MCDC1	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins HuR (ELAVL1) binds and stabilizes mRNA SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses
Diseases		Macular corneal dystrophy (MCD); Corneal dystrophy Groenouw type II; Fehr corneal dystrophy	None
GWAS		Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143 ) Dupuytren's disease ( 28886342 ) Pancreatic cancer ( 25086665 )	Aspartate aminotransferase levels ( 31219225 )
Novel Interactors		1 novel interactors: NUP214	11 novel interactors: ASS1 CHST6 DYNC1I1 LSS MRPS6 NCBP1 NUP98 POMT1 PRRX2 STOM VAV2
Interacting Genes		None recorded	19 interacting genes: APC CLEC4G DDX19B IPO5 NUP107 NUP42 NUP88 NXF1 NXF2 SMAD2 SMAD3 SMAD4 SUMO2 TNPO1 TSG101 XPO1 XPO5 XPOT ZFP36
Entrez ID		4166	8021
HPRD ID		05597	00258
Ensembl ID		ENSG00000183196	ENSG00000126883
Uniprot IDs		Q9GZX3	B7ZAV2 P35658
PDB IDs		Not available	2OIT 3FHC 3FMO 3FMP 5DIS 7R5J 7R5K
GO Terms Enriched among Interactors		Cytoplasmic Side Of Nuclear Pore Structural Constituent Of Nuclear Pore Nuclear Export Signal Receptor Activity Nuclear Localization Sequence Binding Protein Export From Nucleus RNA Export From Nucleus MRNA Export From Nucleus RNA Transport Protein Import Into Nucleus Import Into Nucleus MRNA Transport Nuclear Export Regulation Of Nucleocytoplasmic Transport Nuclear Pore Protein Localization To Nucleus Nucleobase-containing Compound Transport Nuclear Envelope Nuclear Transport Nucleocytoplasmic Transport Regulation Of Intracellular Transport Establishment Of Protein Localization To Organelle	RNA Transport Nuclear Transport Nucleocytoplasmic Transport RNA Export From Nucleus Nuclear Export Nucleobase-containing Compound Transport MRNA Transport Nuclear Pore MRNA Export From Nucleus Intracellular Transport Cellular Localization Establishment Of Localization In Cell Intracellular Protein Transport RNA Binding Nuclear Envelope Protein Transport SMAD Protein Complex Heteromeric SMAD Protein Complex Protein Localization To Nucleus Establishment Of Protein Localization Nuclear Export Signal Receptor Activity Primary MiRNA Processing Protein Import Into Nucleus Import Into Nucleus I-SMAD Binding Cytosol MRNA Binding Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Post-transcriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Poly(A)+ MRNA Export From Nucleus Kinetochore SMAD Protein Signal Transduction R-SMAD Binding Nucleoplasm Activin Receptor Signaling Pathway Intracellular Protein Localization Establishment Of Protein Localization To Organelle Endoderm Development Protein Export From Nucleus MiRNA Processing Mesoderm Morphogenesis Pericardium Development Ribosomal Large Subunit Export From Nucleus Nucleus Trophoblast Cell Migration Ribosomal Small Subunit Export From Nucleus Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery