AGRP and GHRL

Number of citations of the paper that reports this interaction (PMID 11196643)
316

Data Source:
HPRD (in vivo)

		AGRP	GHRL
Gene Name		agouti related neuropeptide	ghrelin/obestatin prepropeptide
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Golgi Lumen Neuronal Cell Body Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Axon Secretory Granule Lumen
	Molecular Function	Receptor Binding Neuropeptide Hormone Activity	G-protein Coupled Receptor Binding Growth Hormone-releasing Hormone Activity Protein Tyrosine Kinase Activator Activity Ghrelin Receptor Binding
	Biological Process	Neuropeptide Signaling Pathway Feeding Behavior Adult Feeding Behavior Photoperiodism Hormone-mediated Signaling Pathway Response To Insulin Eating Behavior Maternal Process Involved In Female Pregnancy Regulation Of Feeding Behavior Positive Regulation Of Feeding Behavior	Activation Of MAPK Activity Gastric Acid Secretion Negative Regulation Of Endothelial Cell Proliferation Glucose Metabolic Process G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Actin Polymerization Or Depolymerization Adult Feeding Behavior Response To Hormone Hormone-mediated Signaling Pathway Dendrite Development Negative Regulation Of Angiogenesis Growth Hormone Secretion Positive Regulation Of Insulin Secretion Regulation Of Response To Food Positive Regulation Of Appetite Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Locomotion Positive Regulation Of Multicellular Organism Growth Regulation Of Cell Proliferation Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Negative Regulation Of Apoptotic Process Cortisol Secretion Response To Estrogen Cellular Protein Metabolic Process Negative Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Insulin Secretion Decidualization Negative Regulation Of Inflammatory Response Cartilage Development Positive Regulation Of Corticotropin Secretion Positive Regulation Of Cortisol Secretion Positive Regulation Of Synapse Assembly Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Growth Hormone Secretion Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: GHRL MC3R MC4R MC5R	8 interactors: ACE2 AGRP GHRHR GHSR LEP MLNR NPY UBQLN1
Entrez ID		181	51738
HPRD ID		09079	05638
Ensembl ID		ENSG00000159723	ENSG00000157017
Uniprot IDs		C6SUN5 O00253	Q9UBU3
PDB IDs		1HYK 1MR0 2IQV	1P7X
Enriched GO Terms of Interacting Partners?		Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Coupled Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Peptide Hormone Secretion Peptide Secretion Hormone Secretion Hormone Transport Peptide Transport Feeding Behavior Positive Regulation Of Cellular Metabolic Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cortisol Secretion Amide Transport Cell Surface Receptor Signaling Pathway Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Homoiothermy Regulation Of Behavior Positive Regulation Of Metabolic Process Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Cortisol Secretion Positive Regulation Of Corticotropin Secretion Positive Regulation Of Appetite Regulation Of Hormone Levels Regulation Of Corticotropin Secretion Regulation Of Growth Hormone Receptor Signaling Pathway Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle, REM Sleep Negative Regulation Of Interleukin-6 Biosynthetic Process Negative Regulation Of Feeding Behavior Diet Induced Thermogenesis Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Growth Hormone Secretion Regulation Of Grooming Behavior Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Adult Feeding Behavior Regulation Of Growth Hormone Secretion Gastric Acid Secretion Growth Hormone Secretion Response To Nutrient Levels Regulation Of Nitrogen Compound Metabolic Process Response To Extracellular Stimulus Metal Ion Homeostasis Regulation Of Feeding Behavior	Adult Feeding Behavior Feeding Behavior Regulation Of Response To Food Regulation Of Appetite Adult Behavior Behavior Female Pregnancy Positive Regulation Of Appetite Regulation Of Hormone Levels Peptide Hormone Secretion Peptide Secretion Response To Insulin Maternal Process Involved In Female Pregnancy Multicellular Organismal Reproductive Process Hormone Secretion Multicellular Organism Reproduction Hormone Transport Peptide Transport Growth Hormone Secretion Digestion Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Reproduction Single-organism Behavior Response To Peptide Hormone Amide Transport Response To Peptide G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Developmental Growth Regulation Of Blood Pressure Cellular Response To Hormone Stimulus Hormone Metabolic Process Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Reproductive Process Regulation Of Peptide Hormone Secretion Eating Behavior Positive Regulation Of Growth Regulation Of Hormone Secretion Negative Regulation Of Peptide Secretion Response To Organonitrogen Compound Regulation Of Developmental Growth Cell Surface Receptor Signaling Pathway Blood Circulation Cell-cell Signaling Positive Regulation Of Multicellular Organism Growth Response To Hormone Regulation Of Vasoconstriction Negative Regulation Of Hormone Secretion Response To Stimulus Regulation Of Protein Metabolic Process Response To Nutrient Levels
Tagcloud ?		agouti amphetamine atrophy cart cocaine contributor dawley focuses harvested histidine hypothalamic hypothalamus intraperitoneally ligases lps mafbx mh murf muscle neuropeptide neuropeptides npy pomc proopiomelanocortin sepsis septic sprague twelve wasting	breeding broiler bw bw49 bw70 bwg chickens desorption fcr feed fi flight genotyped ghrelin ghsr haplotypes igf1r maldi meanwhile rs14011776 rs14011780 rs14011783 rs14678932 rs14986828 rs15675065 rs15675067 rs16675844 snps yellow
Tagcloud (Difference) ?		agouti amphetamine atrophy cart cocaine contributor dawley focuses harvested histidine hypothalamic hypothalamus intraperitoneally ligases lps mafbx mh murf muscle neuropeptide neuropeptides npy pomc proopiomelanocortin sepsis septic sprague twelve wasting	breeding broiler bw bw49 bw70 bwg chickens desorption fcr feed fi flight genotyped ghrelin ghsr haplotypes igf1r maldi meanwhile rs14011776 rs14011780 rs14011783 rs14678932 rs14986828 rs15675065 rs15675067 rs16675844 snps yellow
Tagcloud (Intersection) ?