AGRP

Name	agouti related neuropeptide
Structure
Interactors	4 interactors: GHRL MC3R MC4R MC5R
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Golgi Lumen Neuronal Cell Body
	Molecular Function	Signaling Receptor Binding Neuropeptide Hormone Activity Type 1 Melanocortin Receptor Binding
	Biological Process	Neuropeptide Signaling Pathway Circadian Rhythm Feeding Behavior Adult Feeding Behavior Hormone-mediated Signaling Pathway Response To Insulin Eating Behavior Long-day Photoperiodism Maternal Process Involved In Female Pregnancy Regulation Of Feeding Behavior Positive Regulation Of Feeding Behavior
Pathways	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
GWAS	Blood protein levels ( 30072576 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Refractive error ( 32231278 )
Entrez ID	181
HPRD ID	09079
Ensembl ID	ENSG00000159723
Uniprot IDs	C6SUN5 O00253
PDB IDs	1HYK 1MR0
GO Terms Enriched among Interactors ?	Melanocortin Receptor Activity Regulation Of Feeding Behavior Melanocyte-stimulating Hormone Receptor Activity Regulation Of Behavior Regulation Of Eating Behavior Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Neuropeptide Binding G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Peptide Hormone Secretion Peptide Secretion Feeding Behavior Hormone Transport Hormone Secretion Peptide Transport Ghrelin Receptor Binding Cortisol Secretion Positive Regulation Of Gastric Mucosal Blood Circulation Homoiothermy Amide Transport Response To Melanocyte-stimulating Hormone Growth Hormone-releasing Hormone Activity Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Small Intestinal Transit Positive Regulation Of Growth Rate Signal Release Positive Regulation Of Small Intestine Smooth Muscle Contraction Positive Regulation Of Bone Development Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Eating Behavior Positive Regulation Of Cortisol Secretion Positive Regulation Of Response To Food Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Appetite Regulation Of Gastric Motility Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Neuronal Dense Core Vesicle Lumen Regulation Of Growth Rate Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction Regulation Of Blood Circulation Growth Hormone Secretion Positive Regulation Of Corticotropin Secretion Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Corticotropin Secretion Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Gastric Acid Secretion Positive Regulation Of Growth Hormone Secretion