AGRP and MC4R

Number of citations of the paper that reports this interaction (PMID 10318826)
8

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro, in vivo)

		AGRP	MC4R
Gene Name		agouti related neuropeptide	melanocortin 4 receptor
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Golgi Lumen Neuronal Cell Body Extracellular Vesicular Exosome	Nucleus Plasma Membrane Integral Component Of Membrane
	Molecular Function	Receptor Binding Neuropeptide Hormone Activity	Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Protein Binding Peptide Hormone Binding Ubiquitin Protein Ligase Binding Neuropeptide Binding
	Biological Process	Neuropeptide Signaling Pathway Feeding Behavior Adult Feeding Behavior Photoperiodism Hormone-mediated Signaling Pathway Response To Insulin Eating Behavior Maternal Process Involved In Female Pregnancy Regulation Of Feeding Behavior Positive Regulation Of Feeding Behavior	Diet Induced Thermogenesis Energy Reserve Metabolic Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Feeding Behavior Insulin Secretion Positive Regulation Of CAMP Biosynthetic Process Response To Insulin Positive Regulation Of Bone Resorption Negative Regulation Of Feeding Behavior Regulation Of Grooming Behavior
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Antipsychotic drug-induced weight gain ( 22566560) Body mass index ( 22344221 23563607 19079260 19079261 23669352 18454148 20935630) HDL cholesterol ( 20686565) Height ( 20881960) Obesity ( 23563607 19151714) Obesity (early onset extreme) ( 23563609) Obesity (extreme) ( 20421936) Obesity and blood pressure ( 22013104) Urate levels ( 23263486) Waist circumference ( 19557197) Waist circumference and related phenotypes ( 18454146) Weight ( 19079260)
Protein-Protein Interactions		4 interactors: GHRL MC3R MC4R MC5R	9 interactors: ADRBK1 AGRP ASIP ATRNL1 IL1RAP MC1R NPY POMC PRKACA
Entrez ID		181	4160
HPRD ID		09079	01116
Ensembl ID		ENSG00000159723	ENSG00000166603
Uniprot IDs		C6SUN5 O00253	P32245
PDB IDs		1HYK 1MR0 2IQV	2IQP 2IQR 2IQS 2IQU 2IQV 2IQW
Enriched GO Terms of Interacting Partners?		Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Coupled Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Peptide Hormone Secretion Peptide Secretion Hormone Secretion Hormone Transport Peptide Transport Feeding Behavior Positive Regulation Of Cellular Metabolic Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cortisol Secretion Amide Transport Cell Surface Receptor Signaling Pathway Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Homoiothermy Regulation Of Behavior Positive Regulation Of Metabolic Process Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Cortisol Secretion Positive Regulation Of Corticotropin Secretion Positive Regulation Of Appetite Regulation Of Hormone Levels Regulation Of Corticotropin Secretion Regulation Of Growth Hormone Receptor Signaling Pathway Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle, REM Sleep Negative Regulation Of Interleukin-6 Biosynthetic Process Negative Regulation Of Feeding Behavior Diet Induced Thermogenesis Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Growth Hormone Secretion Regulation Of Grooming Behavior Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Adult Feeding Behavior Regulation Of Growth Hormone Secretion Gastric Acid Secretion Growth Hormone Secretion Response To Nutrient Levels Regulation Of Nitrogen Compound Metabolic Process Response To Extracellular Stimulus Metal Ion Homeostasis Regulation Of Feeding Behavior	Adult Feeding Behavior G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Feeding Behavior Cell Surface Receptor Signaling Pathway Signal Transduction Signaling Cell Communication Neuropeptide Signaling Pathway Feeding Behavior Pigmentation Cellular Response To Stimulus Regulation Of Feeding Behavior Positive Regulation Of Behavior Melanin Biosynthetic Process Melanin Metabolic Process Adult Behavior Regulation Of Appetite Secondary Metabolite Biosynthetic Process Regulation Of Behavior Regulation Of The Force Of Heart Contraction Response To Stimulus Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Peptidyl-threonine Phosphorylation Activation Of Phospholipase C Activity Blood Circulation Positive Regulation Of Phospholipase C Activity Response To Light Stimulus Pigment Biosynthetic Process Cellular Pigmentation Cell-cell Signaling Positive Regulation Of CAMP Biosynthetic Process Cellular Response To Organic Substance Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Phospholipase Activity Positive Regulation Of Dense Core Granule Biogenesis Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Generation Of Precursor Metabolites And Energy Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of Phospholipase Activity Regulation Of Striated Muscle Contraction Positive Regulation Of Lipase Activity Regulation Of CAMP Biosynthetic Process Response To Radiation Single-organism Behavior Cellular Response To Light Stimulus Regulation Of Tumor Necrosis Factor Production Phenol-containing Compound Metabolic Process Regulation Of CAMP Metabolic Process Histone H3-T6 Phosphorylation
Tagcloud ?		agouti amphetamine atrophy cart cocaine contributor dawley focuses harvested histidine hypothalamic hypothalamus intraperitoneally ligases lps mafbx mh murf muscle neuropeptide neuropeptides npy pomc proopiomelanocortin sepsis septic sprague twelve wasting	5i correcting d90n delta88 f261s functionally g98r hek293 i102s i335s impermeable inactivating intracellularly ipsen mc3r mc4rs melanocortin misrouted mutants n274s opioid permeable pharmacoperone rescue rescued retained s58c trafficking y157s
Tagcloud (Difference) ?		agouti amphetamine atrophy cart cocaine contributor dawley focuses harvested histidine hypothalamic hypothalamus intraperitoneally ligases lps mafbx mh murf muscle neuropeptide neuropeptides npy pomc proopiomelanocortin sepsis septic sprague twelve wasting	5i correcting d90n delta88 f261s functionally g98r hek293 i102s i335s impermeable inactivating intracellularly ipsen mc3r mc4rs melanocortin misrouted mutants n274s opioid permeable pharmacoperone rescue rescued retained s58c trafficking y157s
Tagcloud (Intersection) ?