MAGEB4 and SH2D1B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MAGEB4	SH2D1B
Description		MAGE family member B4	SH2 domain containing 1B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Cytosol
	Molecular Function	Protein Binding	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II	Adaptive Immune Response Leukocyte Activation Involved In Immune Response Immune System Process Positive Regulation Of Natural Killer Cell Mediated Immunity Innate Immune Response Positive Regulation Of Innate Immune Response
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS			Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969) Takayasu arteritis ( 25604533)
Interacting Genes		41 interacting genes: AARD ACOT11 ARID3A BLOC1S1 CCDC136 CCDC14 CIMIP2B DVL3 EEF1AKMT3 FAM136A FERD3L FLOT2 FTSJ3 GOLGA6L2 GPATCH2 H2AP HGS IHO1 KANK2 KRT38 LZTS2 MAGEA8 MED21 MESD NEUROD4 PFDN6 PICK1 PJA1 ROCK1 RUNDC3A SH2D1B THOC1 TNR TRAK1 UQCRB USHBP1 USP25 WDR62 YWHAE ZNF341 ZRANB1	25 interacting genes: AGR2 APP AR BLK CD244 CD84 EGFR ERBB2 ERBB3 ERBB4 GAB1 KIT LY9 MAGEB4 MAPK8IP2 MEOX2 MET NFKBID NUTM1 PRDX1 PTK2 SLAMF1 STAT4 TNK2 TRIM54
Entrez ID		4115	117157
HPRD ID		02150	12248
Ensembl ID		ENSG00000120289	ENSG00000198574
Uniprot IDs		O15481	O14796
PDB IDs			5KAZ
Enriched GO Terms of Interacting Partners?			Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of MAPK Cascade Receptor Complex Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Protein Kinase Activity ERBB2 Signaling Pathway Basal Plasma Membrane Leukocyte Activation Immune System Process Kinase Activity Defense Response Regulation Of Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Lymphocyte Activation Cell Activation Signal Transduction Cellular Developmental Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling External Side Of Plasma Membrane Developmental Process Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Phosphorus Metabolic Process Immune Effector Process Cell Differentiation Positive Regulation Of Phosphorylation ERBB3:ERBB2 Complex Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Positive Regulation Of Biosynthetic Process Molecular Function Activator Activity Regulation Of Cell Migration Response To Stress
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