MAGEB4 and UQCRB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MAGEB4	UQCRB
Description		MAGE family member B4	ubiquinol-cytochrome c reductase binding protein
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex III Respiratory Chain Complex
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II	Oxidative Phosphorylation Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Aerobic Respiration Cellular Respiration
Pathways			Respiratory electron transport Complex III assembly Complex III assembly
Drugs			2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol 6-Hydroxy-5-undecyl-4,7-benzothiazoledione Azoxystrobin 5-Heptyl-6-hydroxy-1,3-benzothiazole-4,7-dione (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE (S)-famoxadone METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE 2-Nonyl-4-quinolinol 1-oxide Ubiquinone Q2
Diseases			Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS			Huntington's disease progression ( 28642124)
Interacting Genes		41 interacting genes: AARD ACOT11 ARID3A BLOC1S1 CCDC136 CCDC14 CIMIP2B DVL3 EEF1AKMT3 FAM136A FERD3L FLOT2 FTSJ3 GOLGA6L2 GPATCH2 H2AP HGS IHO1 KANK2 KRT38 LZTS2 MAGEA8 MED21 MESD NEUROD4 PFDN6 PICK1 PJA1 ROCK1 RUNDC3A SH2D1B THOC1 TNR TRAK1 UQCRB USHBP1 USP25 WDR62 YWHAE ZNF341 ZRANB1	9 interacting genes: ACAP1 ACCS HPCA HSPB1 LRRK2 MAGEA1 MAGEA4 MAGEB4 ZSWIM7
Entrez ID		4115	7381
HPRD ID		02150	11770
Ensembl ID		ENSG00000120289	ENSG00000156467
Uniprot IDs		O15481	P14927
PDB IDs			5XTE 5XTH 5XTI
Enriched GO Terms of Interacting Partners?			Response To Ketamine Dendrite Cytoplasm Negative Regulation Of Protein Kinase C Signaling Regulation Of Notch Signaling Pathway Negative Regulation Of Notch Signaling Pathway 1-aminocyclopropane-1-carboxylate Synthase Activity Cellular Response To Curcumin Caveola Neck Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion GTP-dependent Protein Kinase Activity Beta-catenin Destruction Complex Binding Wnt Signalosome Assembly Shu Complex Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Protein Kinase C Inhibitor Activity Positive Regulation Of Protein Autoubiquitination Response To Curcumin Perikaryon Response To Aroclor 1254 Dendritic Spine Head Regulation Of Protein Kinase C Signaling Histone Deacetylase Binding Cytoplasmic Side Of Mitochondrial Outer Membrane Positive Regulation Of Dopamine Receptor Signaling Pathway Multivesicular Body, Internal Vesicle Regulation Of CAMKK-AMPK Signaling Cascade Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Synaptic Vesicle Transport Regulation Of Protein Autoubiquitination Positive Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Protein Targeting To Mitochondrion Regulation Of Kidney Size Tangential Migration From The Subventricular Zone To The Olfactory Bulb Calcium-mediated Signaling Cellular Response To Metal Ion Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Synaptic Vesicle Recycling Cellular Response To Dopamine Intracellular Distribution Of Mitochondria Regulation Of Retrograde Transport, Endosome To Golgi Cellular Response To L-glutamate Anterograde Axonal Protein Transport Regulation Of Intrinsic Apoptotic Signaling Pathway JUN Kinase Kinase Kinase Activity Positive Regulation Of Microglial Cell Activation
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