MAFG and PIDD1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		MAFG	PIDD1
Description		MAF bZIP transcription factor G	p53-induced death domain protein 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm RNA Polymerase II Transcription Regulator Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Endopeptidase Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific Double-stranded DNA Binding	Endopeptidase Activity Death Receptor Binding Protein Binding Hydrolase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Adult Behavior Regulation Of Cell Population Proliferation Regulation Of Epidermal Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Apoptotic Process DNA Damage Response Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Autoprocessing DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway
Pathways		Nuclear events mediated by NFE2L2 NFE2L2 regulates pentose phosphate pathway genes Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production	TP53 Regulates Transcription of Caspase Activators and Caspases
Drugs
Diseases
GWAS			Breast cancer ( 29059683)
Interacting Genes		24 interacting genes: ATF3 BATF3 CHD3 CREBBP CYP2E1 DDIT3 GTF2A1L HIF1A HOMEZ HOXD12 MAF MAPK3 MED31 NFE2 NFE2L1 NFE2L2 NFIL3 PAX6 PIDD1 PPP1CA PRRX1 RBM48 SNRPN VIM	17 interacting genes: AFP ATM CASP2 CCDC85B CRADD EFEMP2 FADD HSD17B14 KHDC4 MADD MAFG MDFI MTNR1B POGZ PRKDC SOX8 TEAD3
Entrez ID		4097	55367
HPRD ID		03605	11284
Ensembl ID		ENSG00000197063	ENSG00000177595
Uniprot IDs		O15525	Q9HB75
PDB IDs		7X5E 7X5F 7X5G	2OF5
Enriched GO Terms of Interacting Partners?		Chromatin RNA Polymerase II Transcription Regulator Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Integrated Stress Response Signaling DNA Binding DNA-binding Transcription Factor Activity Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Nucleus Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To Stress Nucleoplasm Regulation Of Metabolic Process DNA-templated Transcription DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific CHOP-ATF3 Complex Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Astrocyte Differentiation Negative Regulation Of Biosynthetic Process Cellular Response To Cytokine Stimulus Negative Regulation Of Metabolic Process Embryonic Morphogenesis Transcription Cis-regulatory Region Binding Cell Redox Homeostasis	DNA-dependent Protein Kinase Activity Histone H2AXS139 Kinase Activity Endopeptidase Complex Cell Death Programmed Cell Death Signal Transduction In Response To DNA Damage DNA Damage Response, Signal Transduction By P53 Class Mediator Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Mechanical Stimulus Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death V(D)J Recombination Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription By RNA Polymerase II Ectopic Germ Cell Programmed Cell Death Death Receptor Binding Reproductive Process Extrinsic Apoptotic Signaling Pathway Programmed Cell Death Involved In Cell Development Execution Phase Of Apoptosis Double-strand Break Repair Via Homologous Recombination Recombinational Repair Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of RNA Biosynthetic Process Intrinsic Apoptotic Signaling Pathway Positive Regulation Of DNA-templated Transcription Cell Fate Commitment Cellular Developmental Process Ovulation Cycle Process Somitogenesis Peptidyl-serine Phosphorylation DNA Damage Response Somatic Cell DNA Recombination Response To Mechanical Stimulus T Cell Differentiation In Thymus Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Smooth Muscle Cell-matrix Adhesion D-threo-aldose 1-dehydrogenase Activity Thymus Development Positive Regulation Of RNA Metabolic Process Double-strand Break Repair Developmental Process Involved In Reproduction Regulation Of DNA-templated Transcription
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