NTS and NLN

Number of citations of the paper that reports this interaction (PMID 7836437)
11

Data Source:
HPRD (in vitro)

		NTS	NLN
Gene Name		neurotensin	neurolysin (metallopeptidase M3 family)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Transport Vesicle	Mitochondrial Intermembrane Space Plasma Membrane
	Molecular Function	Neuropeptide Hormone Activity Protein Binding	Metalloendopeptidase Activity Peptide Binding Metal Ion Binding
	Biological Process	Signal Transduction Regulation Of Blood Vessel Size	Proteolysis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: ACE2 ARRB2 CPE MEP1A NLN NTSR1 NTSR2 PREP SORT1	2 interactors: APP NTS
Entrez ID		4922	57486
HPRD ID		08878	07495
Ensembl ID		ENSG00000133636	ENSG00000123213
Uniprot IDs		P30990 Q6FH20	Q9BYT8
PDB IDs		2LNE 2LNF 2LNG 2LYW 3F6K
Enriched GO Terms of Interacting Partners?		Neuropeptide Signaling Pathway Proteolysis G-protein Coupled Receptor Signaling Pathway Peptide Hormone Processing Receptor Metabolic Process Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Adult Locomotory Behavior Digestion Angiotensin-mediated Drinking Behavior Angiotensin Catabolic Process In Blood Behavior Peptide Metabolic Process Multicellular Organismal Protein Catabolic Process Adult Behavior Receptor-mediated Virion Attachment To Host Cell Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Follicle-stimulating Hormone Signaling Pathway Insulin Processing Negative Regulation Of Smooth Muscle Cell Apoptotic Process Multicellular Organismal Protein Metabolic Process Hormone Metabolic Process Endosome Transport Via Multivesicular Body Sorting Pathway Receptor Biosynthetic Process Drinking Behavior Virion Attachment To Host Cell Positive Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Lipoprotein Lipase Activity Plasma Membrane To Endosome Transport Cell Surface Receptor Signaling Pathway Glucose Import Brain Renin-angiotensin System Locomotory Behavior Protein Processing Insulin Metabolic Process Adhesion Of Symbiont To Host Cellular Amide Metabolic Process Regulation Of Hormone Levels Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Regulation Of Smooth Muscle Cell Apoptotic Process Peptide Catabolic Process Regulation Of Blood Volume By Renin-angiotensin G-protein Coupled Receptor Internalization Negative Regulation Of Interleukin-1 Beta Production Nerve Growth Factor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Cardiac Left Ventricle Morphogenesis Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Synaptic Transmission, Dopaminergic	Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Neuron Remodeling Cellular Copper Ion Homeostasis Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Neuron Recognition RNA Polyadenylation Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Axon Cargo Transport Mating Neuromuscular Junction Development Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Neuron Apoptotic Process Regulation Of Protein Tyrosine Kinase Activity Visual Learning Glutamate Receptor Signaling Pathway Visual Behavior Neuron Death Platelet Degranulation Regulation Of Blood Vessel Size Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Tube Size Neuromuscular Process Controlling Balance Synapse Assembly MRNA 3'-end Processing Regulation Of ERBB Signaling Pathway Associative Learning Developmental Cell Growth Regulation Of Synapse Structure Or Activity Feeding Behavior Regulation Of Multicellular Organism Growth RNA 3'-end Processing Cholesterol Metabolic Process Adult Locomotory Behavior Positive Regulation Of Mitotic Cell Cycle
Tagcloud ?		acts autocrine cascades competing directed document embedded gxkkxxk homopolymeric localizes mediator mid motif mutagenesis nucleolin nucleolus paracrine parathyroid predict preservation pthrp representing ribonucleoprotein rna rnas salt secreted shared translated	augment axillary ccr7 cd45 clue conditioned cues deadly drained emerge fivefold infiltrated infiltrating intriguingly leukocyte leukocytes lymph mcf microenvironment nlns nodes pln plns secreted secretions skbr3 subsets tals tributaries
Tagcloud (Difference) ?		acts autocrine cascades competing directed document embedded gxkkxxk homopolymeric localizes mediator mid motif mutagenesis nucleolin nucleolus paracrine parathyroid predict preservation pthrp representing ribonucleoprotein rna rnas salt shared translated	augment axillary ccr7 cd45 clue conditioned cues deadly drained emerge fivefold infiltrated infiltrating intriguingly leukocyte leukocytes lymph mcf microenvironment nlns nodes pln plns secretions skbr3 subsets tals tributaries
Tagcloud (Intersection) ?		secreted