NTS and PREP

Number of citations of the paper that reports this interaction (PubMedID 3525564)
0

Data Source:
HPRD (in vitro)

		NTS	PREP
Description		neurotensin	prolyl endopeptidase
Image
GO Annotations	Cellular Component	Extracellular Region Transport Vesicle Cytoplasmic Vesicle Axon Terminus	Extracellular Region Nucleus Cytoplasm Cytosol Membrane
	Molecular Function	Neuropeptide Hormone Activity Protein Binding Receptor Ligand Activity Neuropeptide Receptor Binding	Metallocarboxypeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Oligopeptidase Activity
	Biological Process	Signal Transduction Neuropeptide Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Killing Of Cells Of Another Organism Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Blood Vessel Diameter Maintenance	Angiotensin Maturation Proteolysis
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events
Drugs			1-Hydroxy-1-Thio-Glycerol S-oxy-L-cysteine Z-Pro-Prolinal Monothioglycerol (6S)-1-chloro-3-[(4-fluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)pyrrolo[1,2-a]pyrazin-4(6H)-one 1-{3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propyl}-3-phenylquinoxalin-2(1H)-one 2-{3-[(2S)-4,4-difluoro-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-3-oxopropyl}-isoindole-1,3(2H)-dione
Diseases
GWAS		Metabolite levels ( 23823483)	Asthma ( 27611488) Beard thickness ( 26926045) Blood protein levels ( 30072576) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Multiple sclerosis ( 31604244) Response to (pegylated) interferon in HBeAG-positive hepatitis B ( 30715261) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		10 interacting genes: ACE2 ARRB2 CPE MEP1A MFF NLN NTSR1 NTSR2 PREP SORT1	7 interacting genes: AGT BRCA1 KNG1 NTS OXT SNCA TAC1
Entrez ID		4922	5550
HPRD ID		08878	02673
Ensembl ID		ENSG00000133636	ENSG00000085377
Uniprot IDs		P30990 Q6FH20	B2RAH7 P48147
PDB IDs		2LNE 2LNF 2LNG 2LYW 2OYV 2OYW 3F6K 4PO7 5LUZ 6UP7 8VJY	3DDU
Enriched GO Terms of Interacting Partners?		Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Neuropeptide Signaling Pathway Metallocarboxypeptidase Activity G Protein-coupled Neurotensin Receptor Activity Metallopeptidase Activity Hormone Metabolic Process Peptidase Activity Protein Processing Proteolysis Protein Maturation Angiotensin Maturation G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Amino Acid Transport Carboxypeptidase Activity Regulation Of Biological Quality Regulation Of Hormone Levels Import Into Cell Peptide Metabolic Process Neurotensin Receptor Activity, Non-G Protein-coupled Plasma Membrane Endocytic Vesicle Membrane Angiotensin Receptor Binding Clathrin-coated Pit Adult Locomotory Behavior Cytoplasmic Vesicle Epidermal Growth Factor Receptor Ligand Maturation Meprin A Complex Inositol Phosphate Catabolic Process Regulation Of Amine Transport Oligopeptidase Activity Nerve Growth Factor Receptor Activity Positive Regulation Of L-proline Import Across Plasma Membrane Angiotensin-mediated Drinking Behavior Peptidyl-dipeptidase Activity Regulation Of Striated Muscle Cell Differentiation Hydrolase Activity Metalloendopeptidase Activity Positive Regulation Of Synaptic Transmission, Dopaminergic Regulation Of Membrane Potential Membrane Protein Localization To Secretory Granule Positive Regulation Of Gamma-aminobutyric Acid Secretion Entry Receptor-mediated Virion Attachment To Host Cell Endocytosis Amino Acid Transport Symmetric Synapse Regulation Of Skeletal Muscle Fiber Differentiation Viral Translation Viral Life Cycle	Positive Regulation Of Cellular Component Biogenesis Blood Vessel Diameter Maintenance Hormone Activity Regulation Of Reactive Oxygen Species Metabolic Process Receptor Ligand Activity Regulation Of Tube Size Regulation Of Lipid Transport Extracellular Region Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Cytosolic Calcium Ion Concentration Antimicrobial Humoral Response Killing Of Cells Of Another Organism Positive Regulation Of Synaptic Transmission Positive Regulation Of Inflammatory Response Regulation Of Blood Pressure Neuronal Dense Core Vesicle Regulation Of Secretion By Cell Cell Killing Regulation Of Heart Contraction Regulation Of Secretion Neuropeptide Hormone Activity Regulation Of Biological Quality Cysteine-type Endopeptidase Inhibitor Activity Extracellular Space System Process Regulation Of Blood Circulation Regulation Of Catecholamine Secretion Terminal Bouton Regulation Of Cell Junction Assembly Vascular Process In Circulatory System Regulation Of Microtubule-based Process Humoral Immune Response Response To Cocaine Regulation Of Multicellular Organismal Process Negative Regulation Of Blood Pressure Positive Regulation Of Secretion By Cell Positive Regulation Of Cell Communication Positive Regulation Of Signaling Circulatory System Process Axon Terminus Positive Regulation Of Secretion Positive Regulation Of Ossification Regulation Of Lipid Metabolic Process Regulation Of Small Molecule Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Response To Activity Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Hindgut Contraction Oxytocin Receptor Binding
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