NTS and ACE2

Number of citations of the paper that reports this interaction (PMID 11815627)
122

Data Source:
HPRD (in vitro)

		NTS	ACE2
Gene Name		neurotensin	angiotensin I converting enzyme 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Transport Vesicle	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Cell Surface Integral Component Of Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Neuropeptide Hormone Activity Protein Binding	Virus Receptor Activity Glycoprotein Binding Endopeptidase Activity Carboxypeptidase Activity Protein Binding Metallopeptidase Activity Peptidyl-dipeptidase Activity Zinc Ion Binding Peptide Hormone Binding
	Biological Process	Signal Transduction Regulation Of Blood Vessel Size	Regulation Of Cytokine Production Angiotensin Maturation Angiotensin Catabolic Process In Blood Angiotensin-mediated Drinking Behavior Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Proteolysis Response To Virus Regulation Of Vasoconstriction Receptor Biosynthetic Process Regulation Of Cell Proliferation Regulation Of Vasodilation Cellular Protein Metabolic Process Viral Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Regulation Of Inflammatory Response Maternal Process Involved In Female Pregnancy Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Peptide hormone metabolism Metabolism of Angiotensinogen to Angiotensins
Drugs			Moexipril Lisinopril
Diseases
GWAS
Protein-Protein Interactions		9 interactors: ACE2 ARRB2 CPE MEP1A NLN NTSR1 NTSR2 PREP SORT1	3 interactors: AGT GHRL NTS
Entrez ID		4922	59272
HPRD ID		08878	02274
Ensembl ID		ENSG00000133636	ENSG00000130234
Uniprot IDs		P30990 Q6FH20	Q9BYF1
PDB IDs		2LNE 2LNF 2LNG 2LYW 3F6K	1R42 1R4L 1XJP 2AJF 3D0G 3D0H 3D0I 3KBH 3SCI 3SCJ
Enriched GO Terms of Interacting Partners?		Neuropeptide Signaling Pathway Proteolysis G-protein Coupled Receptor Signaling Pathway Peptide Hormone Processing Receptor Metabolic Process Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Adult Locomotory Behavior Digestion Angiotensin-mediated Drinking Behavior Angiotensin Catabolic Process In Blood Behavior Peptide Metabolic Process Multicellular Organismal Protein Catabolic Process Adult Behavior Receptor-mediated Virion Attachment To Host Cell Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Follicle-stimulating Hormone Signaling Pathway Insulin Processing Negative Regulation Of Smooth Muscle Cell Apoptotic Process Multicellular Organismal Protein Metabolic Process Hormone Metabolic Process Endosome Transport Via Multivesicular Body Sorting Pathway Receptor Biosynthetic Process Drinking Behavior Virion Attachment To Host Cell Positive Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Lipoprotein Lipase Activity Plasma Membrane To Endosome Transport Cell Surface Receptor Signaling Pathway Glucose Import Brain Renin-angiotensin System Locomotory Behavior Protein Processing Insulin Metabolic Process Adhesion Of Symbiont To Host Cellular Amide Metabolic Process Regulation Of Hormone Levels Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Regulation Of Smooth Muscle Cell Apoptotic Process Peptide Catabolic Process Regulation Of Blood Volume By Renin-angiotensin G-protein Coupled Receptor Internalization Negative Regulation Of Interleukin-1 Beta Production Nerve Growth Factor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Cardiac Left Ventricle Morphogenesis Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Synaptic Transmission, Dopaminergic	Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Multicellular Organism Growth Regulation Of Protein Tyrosine Kinase Activity Regulation Of Blood Vessel Size Regulation Of Tube Size Negative Regulation Of Angiogenesis Feeding Behavior Regulation Of Multicellular Organism Growth Uterine Smooth Muscle Contraction Cortisol Secretion Angiotensin Mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Developmental Growth Regulation Of Peptidyl-tyrosine Phosphorylation Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Positive Regulation Of Protein Kinase C Activity Catenin Import Into Nucleus Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Renal Response To Blood Flow Involved In Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure Regulation Of Angiogenesis Positive Regulation Of Growth Female Pregnancy Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Angiotensin-mediated Drinking Behavior Smooth Muscle Cell Proliferation Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of NAD(P)H Oxidase Activity Positive Regulation Of Extracellular Matrix Constituent Secretion G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Ovarian Follicle Rupture Regulation Of Renal Output By Angiotensin Regulation Of Hormone Levels Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Inflammatory Response Regulation Of Developmental Growth Positive Regulation Of Appetite Positive Regulation Of Cortisol Secretion Positive Regulation Of Corticotropin Secretion Fibroblast Proliferation Astrocyte Activation Renin-angiotensin Regulation Of Aldosterone Production Blood Circulation Positive Regulation Of Secretion Regulation Of Corticotropin Secretion Regulation Of Growth Hormone Receptor Signaling Pathway Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Regulation Of Blood Vessel Size By Renin-angiotensin Negative Regulation Of Interleukin-6 Biosynthetic Process Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
Tagcloud ?		acts autocrine cascades competing directed document embedded gxkkxxk homopolymeric localizes mediator mid motif mutagenesis nucleolin nucleolus paracrine parathyroid predict preservation pthrp representing ribonucleoprotein rna rnas salt secreted shared translated	aav adeno blunt blunted blunts bp contribution cre doca floxed gfp hace2 harboring hypertension icv infused neurogenic nt paraventricular pvn recombinase salt sfo sham sl subfornical transgene transgenic tudca
Tagcloud (Difference) ?		acts autocrine cascades competing directed document embedded gxkkxxk homopolymeric localizes mediator mid motif mutagenesis nucleolin nucleolus paracrine parathyroid predict preservation pthrp representing ribonucleoprotein rna rnas secreted shared translated	aav adeno blunt blunted blunts bp contribution cre doca floxed gfp hace2 harboring hypertension icv infused neurogenic nt paraventricular pvn recombinase sfo sham sl subfornical transgene transgenic tudca
Tagcloud (Intersection) ?		salt