RIPK2 and CASP1

Number of citations of the paper that reports this interaction (PubMedID 9705938)
0

Data Source:
HPRD (in vivo)

		RIPK2	CASP1
Description		receptor interacting serine/threonine kinase 2	caspase 1
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol Cytoskeleton Plasma Membrane Membrane Vesicle Protein-containing Complex	Nucleolus Cytoplasm Cytosol Microtubule Plasma Membrane Membrane Protein-containing Complex Canonical Inflammasome Complex IPAF Inflammasome Complex NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex Protease Inhibitor Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity LIM Domain Binding Signaling Adaptor Activity Identical Protein Binding Protein Homodimerization Activity CARD Domain Binding Caspase Binding Protein Serine Kinase Activity	Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Hydrolase Activity Enzyme Binding Kinase Binding Cytokine Binding Identical Protein Binding CARD Domain Binding
	Biological Process	Positive Regulation Of Cytokine Production Positive Regulation Of Cytokine-mediated Signaling Pathway Adaptive Immune Response Immune System Process Positive Regulation Of T-helper 1 Type Immune Response Apoptotic Process Inflammatory Response Signal Transduction Canonical NF-kappaB Signal Transduction JNK Cascade Cytokine-mediated Signaling Pathway Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Immature T Cell Proliferation In Thymus Positive Regulation Of Immature T Cell Proliferation In Thymus Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway CD4-positive, Alpha-beta T Cell Proliferation P38MAPK Cascade T Cell Proliferation Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-positive Bacterium T Cell Receptor Signaling Pathway Protein Homooligomerization Stress-activated MAPK Cascade Positive Regulation Of Macrophage Cytokine Production ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Response To Interleukin-1 Response To Interleukin-12 Response To Interleukin-18 Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Peptidoglycan Cellular Response To Muramyl Dipeptide Regulation Of Primary Metabolic Process Protein Linear Polyubiquitination Xenophagy Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Xenophagy Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation	Negative Regulation Of Transcription By RNA Polymerase II Plasma Membrane Repair Pattern Recognition Receptor Signaling Pathway Proteolysis Apoptotic Process Inflammatory Response Signal Transduction Osmosensory Signaling Pathway Protein Secretion Protein Autoprocessing Protein Catabolic Process Response To Lipopolysaccharide Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-18 Production Interleukin-18-mediated Signaling Pathway Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Icosanoid Biosynthetic Process Ceramide Biosynthetic Process Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Protein Maturation Defense Response To Virus Protein Poly-ADP-ribosylation Pyroptotic Inflammatory Response Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Type II Interferon Cytokine Precursor Processing Signaling Receptor Ligand Precursor Processing AIM2 Inflammasome Complex Assembly Pyroptotic Cell Death Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Pathways		NOD1/2 Signaling Pathway NOD1/2 Signaling Pathway Downstream TCR signaling p75NTR recruits signalling complexes TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Ovarian tumor domain proteases Interleukin-1 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses	NOD1/2 Signaling Pathway Interleukin-1 processing Pyroptosis TP53 Regulates Transcription of Caspase Activators and Caspases The NLRP3 inflammasome The AIM2 inflammasome The IPAF inflammasome Interleukin-37 signaling Purinergic signaling in leishmaniasis infection SARS-CoV-1 activates/modulates innate immune responses
Drugs		Fostamatinib	Acetylsalicylic acid Minocycline Pralnacasan LAX-101 Emricasan VX-765 1-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDE Z-Val-Ala-Asp fluoromethyl ketone 3-{6-[(8-HYDROXY-QUINOLINE-2-CARBONYL)-AMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-4-OXO-BUTYRI ACID
Diseases
GWAS		Cerebral amyloid deposition (PET imaging) ( 26252872) Cognitive performance ( 20125193) Crohn's disease ( 23128233) Leprosy ( 20018961 25642632 27976721)	Hip circumference adjusted for BMI ( 28552196)
Interacting Genes		38 interacting genes: ATG16L1 BCL10 BECN1 BIRC2 CARD16 CARD6 CASP1 CASP8 CD40 CFLAR CHUK IKBKG IRAK1 KDM3A LRRK2 MAVS NGFR NOD1 NOD2 PELI3 PRMT2 SMAD4 SMURF1 TLR2 TLR4 TNFRSF1A TRAF1 TRAF2 TRAF5 TRAF6 UBC UBE2I ULK1 YWHAB YWHAE YWHAG YWHAQ ZNRF4	46 interacting genes: AR ATN1 ATXN3 BCAP31 BCL2L1 BID CARD16 CARD17P CARD8 CASP10 CASP14 CASP8 CAST CDK11B CFTR EGFR FGF2 GSDMD HTT HUWE1 IL18 IL1A IL1B IL33 IL37 LMNA MAPT NEDD4 NFE2L2 NLRC4 NLRP1 NOD1 PAK1 PARP1 PLA2G4A PLA2G4B PRKN PSEN1 PSEN2 PYCARD RIPK2 RNF31 SERPINB9 TFAP2A TIRAP VAC14
Entrez ID		8767	834
HPRD ID		04585	00977
Ensembl ID		ENSG00000104312	ENSG00000137752
Uniprot IDs		A0A0S2Z4Z8 O43353	A8K249 A8K257 P29466
PDB IDs		2N7Z 2N83 4C8B 5AR2 5AR3 5AR4 5AR5 5AR7 5AR8 5J79 5J7B 5NG0 5NG2 5NG3 5W5J 5W5O 5YRN 6ES0 6FU5 6GFJ 6GGS 6HMX 6RN8 6RNA 6S1F 6SZE 6SZJ 6UL8 7OBS 7OBT 8AZA 8X2O 9F3V	1BMQ 1IBC 1ICE 1RWK 1RWM 1RWN 1RWO 1RWP 1RWV 1RWW 1RWX 1SC1 1SC3 1SC4 2FQQ 2H48 2H4W 2H4Y 2H51 2H54 2HBQ 2HBR 2HBY 2HBZ 3D6F 3D6H 3D6M 3E4C 3NS7 5FNA 5MMV 5MTK 6BZ9 6F6R 6KN0 6PZP 6VIE 7KEU 8SV1 8WRA
Enriched GO Terms of Interacting Partners?		Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Activation Of Innate Immune Response Regulation Of Apoptotic Process Positive Regulation Of Defense Response Regulation Of Programmed Cell Death Identical Protein Binding Immune Response-regulating Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Immune Response Immune Response-activating Signaling Pathway Regulation Of Immune Response Regulation Of Defense Response Signal Transduction CD40 Receptor Complex Intracellular Signaling Cassette Positive Regulation Of Innate Immune Response Positive Regulation Of Immune System Process Intracellular Signal Transduction Activation Of Immune Response Protein-containing Complex Binding Response To External Biotic Stimulus CARD Domain Binding Cellular Response To Oxygen-containing Compound Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cytokine Production Response To Other Organism Regulation Of Cytokine Production Regulation Of Cytokine-mediated Signaling Pathway Signaling Adaptor Activity Cell Surface Receptor Signaling Pathway Defense Response Regulation Of Immune System Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Response To Stress	Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Programmed Cell Death Cell Death Response To Stress Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Positive Regulation Of Cell Communication Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Gene Expression Regulation Of Interleukin-1 Beta Production Regulation Of Multicellular Organismal Process Regulation Of Defense Response Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Inflammatory Response Regulation Of Interleukin-1 Production Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Signaling Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Communication Regulation Of Cytokine Production Regulation Of Immune Response Positive Regulation Of Cytokine Production Response To External Biotic Stimulus Positive Regulation Of Interleukin-1 Beta Production Apoptotic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Metabolic Process Positive Regulation Of Programmed Cell Death Defense Response Positive Regulation Of Defense Response Positive Regulation Of Interleukin-1 Production Defense Response To Bacterium Identical Protein Binding Negative Regulation Of Apoptotic Signaling Pathway Cytosol Protein-containing Complex Negative Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Regulation Of Innate Immune Response Response To Lipid Regulation Of Immune System Process Canonical Inflammasome Complex Intracellular Signal Transduction
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