RIPK2 and MAVS

Number of citations of the paper that reports this interaction (PubMedID 21903422)
55

Data Source:
BioGRID (pull down)

		RIPK2	MAVS
Description		receptor interacting serine/threonine kinase 2	mitochondrial antiviral signaling protein
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol Cytoskeleton Plasma Membrane Membrane Vesicle Protein-containing Complex	Ubiquitin Ligase Complex Mitochondrion Mitochondrial Outer Membrane Peroxisome Peroxisomal Membrane Membrane Mitochondrial Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity LIM Domain Binding Signaling Adaptor Activity Identical Protein Binding Protein Homodimerization Activity CARD Domain Binding Caspase Binding Protein Serine Kinase Activity	Protein Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Signaling Adaptor Activity Identical Protein Binding CARD Domain Binding Molecular Adaptor Activity Protein Serine/threonine Kinase Binding DNA-binding Transcription Factor Binding Molecular Condensate Scaffold Activity
	Biological Process	Positive Regulation Of Cytokine Production Positive Regulation Of Cytokine-mediated Signaling Pathway Adaptive Immune Response Immune System Process Positive Regulation Of T-helper 1 Type Immune Response Apoptotic Process Inflammatory Response Signal Transduction Canonical NF-kappaB Signal Transduction JNK Cascade Cytokine-mediated Signaling Pathway Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Immature T Cell Proliferation In Thymus Positive Regulation Of Immature T Cell Proliferation In Thymus Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway CD4-positive, Alpha-beta T Cell Proliferation P38MAPK Cascade T Cell Proliferation Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-positive Bacterium T Cell Receptor Signaling Pathway Protein Homooligomerization Stress-activated MAPK Cascade Positive Regulation Of Macrophage Cytokine Production ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Response To Interleukin-1 Response To Interleukin-12 Response To Interleukin-18 Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Peptidoglycan Cellular Response To Muramyl Dipeptide Regulation Of Primary Metabolic Process Protein Linear Polyubiquitination Xenophagy Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Xenophagy Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation	Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Immune System Process Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway Signal Transduction MRNA Transcription Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction NLRP3 Inflammasome Complex Assembly Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Protein Localization To Mitochondrion Cellular Response To Exogenous DsRNA Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of IP-10 Production Antiviral Innate Immune Response Regulation Of Peroxisome Organization Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Pathways		NOD1/2 Signaling Pathway NOD1/2 Signaling Pathway Downstream TCR signaling p75NTR recruits signalling complexes TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Ovarian tumor domain proteases Interleukin-1 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses	DDX58/IFIH1-mediated induction of interferon-alpha/beta Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses PKR-mediated signaling
Drugs		Fostamatinib
Diseases
GWAS		Cerebral amyloid deposition (PET imaging) ( 26252872) Cognitive performance ( 20125193) Crohn's disease ( 23128233) Leprosy ( 20018961 25642632 27976721)	Platelet distribution width ( 32888494)
Interacting Genes		38 interacting genes: ATG16L1 BCL10 BECN1 BIRC2 CARD16 CARD6 CASP1 CASP8 CD40 CFLAR CHUK IKBKG IRAK1 KDM3A LRRK2 MAVS NGFR NOD1 NOD2 PELI3 PRMT2 SMAD4 SMURF1 TLR2 TLR4 TNFRSF1A TRAF1 TRAF2 TRAF5 TRAF6 UBC UBE2I ULK1 YWHAB YWHAE YWHAG YWHAQ ZNRF4	32 interacting genes: ABL1 CCDC50 CNTN1 DDX3X EIF2AK2 IKBKB IRF3 IRF5 IRF7 KCNIP3 MAP1LC3A MAP3K7 OAS3 OTUD4 RIGI RIPK2 RNF115 RNF125 RNF135 RNF34 SMURF2 STAT1 TBK1 TICAM1 TNKS TNKS2 TRAF3 TRAF6 TRIM31 UBC UBE4A USP25
Entrez ID		8767	57506
HPRD ID		04585	13847
Ensembl ID		ENSG00000104312	ENSG00000088888
Uniprot IDs		A0A0S2Z4Z8 O43353	Q7Z434
PDB IDs		2N7Z 2N83 4C8B 5AR2 5AR3 5AR4 5AR5 5AR7 5AR8 5J79 5J7B 5NG0 5NG2 5NG3 5W5J 5W5O 5YRN 6ES0 6FU5 6GFJ 6GGS 6HMX 6RN8 6RNA 6S1F 6SZE 6SZJ 6UL8 7OBS 7OBT 8AZA 8X2O 9F3V	2MS7 2MS8 2VGQ 3J6C 3J6J 3RC5 4P4H 4Z8M 5JEK 7DNI 8WKW
Enriched GO Terms of Interacting Partners?		Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Activation Of Innate Immune Response Regulation Of Apoptotic Process Positive Regulation Of Defense Response Regulation Of Programmed Cell Death Identical Protein Binding Immune Response-regulating Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Immune Response Immune Response-activating Signaling Pathway Regulation Of Immune Response Regulation Of Defense Response Signal Transduction CD40 Receptor Complex Intracellular Signaling Cassette Positive Regulation Of Innate Immune Response Positive Regulation Of Immune System Process Intracellular Signal Transduction Activation Of Immune Response Protein-containing Complex Binding Response To External Biotic Stimulus CARD Domain Binding Cellular Response To Oxygen-containing Compound Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cytokine Production Response To Other Organism Regulation Of Cytokine Production Regulation Of Cytokine-mediated Signaling Pathway Signaling Adaptor Activity Cell Surface Receptor Signaling Pathway Defense Response Regulation Of Immune System Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Response To Stress	Positive Regulation Of Type I Interferon Production Pattern Recognition Receptor Signaling Pathway Regulation Of Type I Interferon Production Innate Immune Response-activating Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Activation Of Innate Immune Response Immune Response-activating Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Interferon-beta Production Positive Regulation Of Interferon-beta Production Immune Response-regulating Signaling Pathway Activation Of Immune Response Intracellular Receptor Signaling Pathway Response To Virus Regulation Of Defense Response Positive Regulation Of Defense Response Defense Response To Virus Positive Regulation Of Interferon-alpha Production Antiviral Innate Immune Response Positive Regulation Of Cytokine Production Regulation Of Immune Response Positive Regulation Of Immune Response Regulation Of Cytokine Production Protein Polyubiquitination Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Innate Immune Response Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Defense Response To Symbiont MyD88-independent Toll-like Receptor Signaling Pathway Protein Ubiquitination Defense Response To Other Organism Response To Other Organism Response To External Biotic Stimulus Regulation Of Immune System Process Immune Response Protein Modification By Small Protein Conjugation Immune System Process Positive Regulation Of Immune System Process Defense Response Protein Modification Process Cytokine-mediated Signaling Pathway Post-translational Protein Modification Positive Regulation Of Gene Expression Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cytosol
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