UBA52 and USP46

Number of citations of the paper that reports this interaction (PubMedID 22043315)
23

Data Source:
BioGRID (enzymatic study)

		UBA52	USP46
Description		ubiquitin A-52 residue ribosomal protein fusion product 1	ubiquitin specific peptidase 46
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GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrial Outer Membrane Lysosomal Membrane Endoplasmic Reticulum Membrane Cytosol Ribosome Plasma Membrane Endosome Membrane Large Ribosomal Subunit Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Endocytic Vesicle Membrane Vesicle Extracellular Exosome Ribonucleoprotein Complex	Nucleus Cytoplasm Cytosol Synapse Glutamatergic Synapse
	Molecular Function	Structural Constituent Of Ribosome Protein Binding Protein Tag Activity Ubiquitin Protein Ligase Binding	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Metal Ion Binding Deubiquitinase Activity
	Biological Process	Cytoplasmic Translation Translation Protein Ubiquitination Response To Insecticide Modification-dependent Protein Catabolic Process Protein Modification Process	Behavioral Fear Response Proteolysis Adult Feeding Behavior Protein Deubiquitination Regulation Of Protein Stability Regulation Of Synaptic Transmission, GABAergic Behavioral Response To Ethanol Righting Reflex Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Activation of NF-kappaB in B cells ISG15 antiviral mechanism Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants ER-Phagosome pathway Downregulation of ERBB4 signaling Spry regulation of FGF signaling Downregulation of ERBB2:ERBB3 signaling L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation Budding and maturation of HIV virion NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment DDX58/IFIH1-mediated induction of interferon-alpha/beta APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Membrane binding and targetting of GAG proteins Assembly Of The HIV Virion APC-Cdc20 mediated degradation of Nek2A SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G EGFR downregulation SCF(Skp2)-mediated degradation of p27/p21 Viral mRNA Translation Degradation of beta-catenin by the destruction complex TCF dependent signaling in response to WNT Downstream TCR signaling NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival Regulation of activated PAK-2p34 by proteasome mediated degradation NOTCH1 Intracellular Domain Regulates Transcription Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Selenocysteine synthesis Separation of Sister Chromatids Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Regulation of PLK1 Activity at G2/M Transition Constitutive Signaling by NOTCH1 PEST Domain Mutants Stimuli-sensing channels Constitutive Signaling by NOTCH1 HD Domain Mutants FCERI mediated NF-kB activation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus Regulation of innate immune responses to cytosolic DNA Glycogen synthesis Autodegradation of the E3 ubiquitin ligase COP1 Deactivation of the beta-catenin transactivating complex Myoclonic epilepsy of Lafora ABC-family proteins mediated transport TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Regulation of FZD by ubiquitination PINK1-PRKN Mediated Mitophagy N-glycan trimming in the ER and Calnexin/Calreticulin cycle Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Hedgehog 'on' state Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway Negative regulation of MAPK pathway Regulation of necroptotic cell death NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAP3K8 (TPL2)-dependent MAPK1/3 activation HDR through Homologous Recombination (HRR) MAPK6/MAPK4 signaling UCH proteinases UCH proteinases Josephin domain DUBs Ub-specific processing proteases Ovarian tumor domain proteases Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Processing of DNA double-strand break ends DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Fanconi Anemia Pathway Major pathway of rRNA processing in the nucleolus and cytosol Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation Negative regulation of MET activity Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 Cyclin D associated events in G1 G2/M Checkpoints Stabilization of p53 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Ubiquitin-dependent degradation of Cyclin D PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Downregulation of ERBB2 signaling VLDLR internalisation and degradation Synthesis of active ubiquitin: roles of E1 and E2 enzymes Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins InlB-mediated entry of Listeria monocytogenes into host cell InlB-mediated entry of Listeria monocytogenes into host cell InlA-mediated entry of Listeria monocytogenes into host cells RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN localization Regulation of PTEN stability and activity Neddylation ER Quality Control Compartment (ERQC) Regulation of expression of SLITs and ROBOs Regulation of expression of SLITs and ROBOs NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus TICAM1-dependent activation of IRF3/IRF7 TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling Peroxisomal protein import Peroxisomal protein import Interferon alpha/beta signaling Regulation of signaling by CBL Endosomal Sorting Complex Required For Transport (ESCRT) Iron uptake and transport Negative regulators of DDX58/IFIH1 signaling Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Negative regulation of NOTCH4 signaling Chaperone Mediated Autophagy Late endosomal microautophagy Response of EIF2AK4 (GCN2) to amino acid deficiency Prevention of phagosomal-lysosomal fusion Modulation by Mtb of host immune system Alpha-protein kinase 1 signaling pathway Aggrephagy Aggrephagy RAS processing Pexophagy Signaling by CSF1 (M-CSF) in myeloid cells Maturation of protein E SARS-CoV-1 activates/modulates innate immune responses Maturation of protein E Inactivation of CSF3 (G-CSF) signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses Negative regulation of FLT3 FLT3 signaling by CBL mutants Regulation of BACH1 activity Signaling by ALK fusions and activated point mutants TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation KEAP1-NFE2L2 pathway Regulation of NF-kappa B signaling Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Amyloid fiber formation Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation Antigen processing: Ubiquitination & Proteasome degradation Evasion by RSV of host interferon responses Regulation of pyruvate metabolism GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) PD-L1(CD274) glycosylation and translocation to plasma membrane Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS			Biochemical measures ( 19260141) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Height ( 31562340) Platelet count ( 29403010) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 30297969)
Interacting Genes		44 interacting genes: ACVR1 ARRDC3 BMPR1B DAZAP2 DESI1 DNAJB2 EPN2 EPN3 FAM168A FILNC1 FNDC3B FSHR GRB2 HERC3 HGS KHDRBS1 LAPTM5 LITAF MAPK6 MTURN NCK1 PLEKHB2 PLSCR4 POLI RABGEF1 RAD23A RNF11 SEC23B SLC2A4 SMAD1 SMAD2 SMAD4 SMURF1 SNCA SQSTM1 TAX1BP1 TGFBR1 TSG101 UBQLN1 UBQLN2 USP46 USP7 VPS28 WBP2	6 interacting genes: GRIA1 H2AC20 H2BC21 MAPK8IP2 UBA52 UBC
Entrez ID		7311	64854
HPRD ID		08931	07507
Ensembl ID		ENSG00000221983	ENSG00000109189
Uniprot IDs		P62987 Q3MIH3 Q7Z4P3	P62068
PDB IDs		2LJ5 2MBH 2MJB 2MUR 2N3U 2N3V 2N3W 2NBD 2NBE 2RSU 4HJK 4JIO 4P4H 4PIG 4PIH 4PIJ 4RF0 4RF1 4S1Z 4UG0 4V6X 4XKL 5AJ0 5GO7 5GO8 5GOB 5GOC 5GOD 5GOG 5GOH 5GOI 5GOJ 5GOK 5HPK 5HPL 5HPS 5HPT 5J26 5J8P 5JBV 5JBY 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7AY1 7BHP 7F5S 7M3Q 7OWC 7UN3 7WFC 7XD0 7XNX 7XNY 7ZF1 7ZH3 7ZH4 8A3D 8IFD 8IFE 8IK6 8IKM 8IKT 8IKV 8IPJ 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO	5CVM 5CVN 5CVO 5L8H 6JLQ
Enriched GO Terms of Interacting Partners?		Endosome I-SMAD Binding SMAD Binding Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Establishment Of Protein Localization To Vacuole Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Signal Transduction Regulation Of Protein Catabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Metabolic Process Protein Localization To Vacuole Transforming Growth Factor Beta Receptor Activity, Type I Ubiquitin Binding Protein-containing Complex Positive Regulation Of Macromolecule Metabolic Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Protein Complex Regulation Of Protein Ubiquitination Heteromeric SMAD Protein Complex Ubiquitin Protein Ligase Binding Cytoplasm Activin Receptor Signaling Pathway Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Primary Metabolic Process Modification-dependent Protein Catabolic Process BMP Signaling Pathway Polyubiquitin Modification-dependent Protein Binding Regulation Of Post-translational Protein Modification Transmembrane Receptor Protein Serine/threonine Kinase Activity Vacuolar Transport Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Sequestering Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Proteolysis Proteolysis Regulation Of Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Homomeric SMAD Protein Complex Positive Regulation Of Ubiquitin-dependent Endocytosis Regulation Of Metabolic Process Proteolysis Involved In Protein Catabolic Process Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Targeting To Vacuole	Endocytic Vesicle Membrane Protein Tag Activity Positive Regulation Of Locomotion Involved In Locomotory Behavior Axonal Spine Amyloid-beta Binding Regulation Of Nervous System Process Modulation Of Excitatory Postsynaptic Potential Cellular Response To Amine Stimulus Regulation Of Behavior Perisynaptic Space Response To Toxic Substance Modulation Of Chemical Synaptic Transmission Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic Protein Heterodimerization Activity Nucleosome Structural Constituent Of Chromatin Response To Psychosocial Stress Response To Fungicide Conditioned Place Preference Regulation Of Locomotion Involved In Locomotory Behavior Glutamate Receptor Binding Response To Sucrose Immunoglobulin Binding Response To Ammonium Ion Cellular Response To Ammonium Ion Dendritic Spine AMPA Glutamate Receptor Activity Ionotropic Glutamate Receptor Complex Learning Beta-2 Adrenergic Receptor Binding Response To Disaccharide Cellular Component Assembly Ribosome Vesicle Response To Insecticide RNA Strand Annealing Activity Nuclear Pore Localization Intracellular Membraneless Organelle Nonassociative Learning Regulation Of Synaptic Plasticity Neuron Spine Cellular Response To Brain-derived Neurotrophic Factor Stimulus Glutamate-gated Calcium Ion Channel Activity Proximal Dendrite Cellular Response To L-glutamate Mitochondrial Outer Membrane Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Non-motile Cilium Assembly Signal Complex Assembly
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