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UBA52 and ACVR1
Number of citations of the paper that reports this interaction (PubMedID
15761153
)
0
Data Source:
HPRD
(in vivo)
UBA52
ACVR1
Description
ubiquitin A-52 residue ribosomal protein fusion product 1
activin A receptor type 1
Image
GO Annotations
Cellular Component
Extracellular Space
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrial Outer Membrane
Lysosomal Membrane
Endoplasmic Reticulum Membrane
Cytosol
Ribosome
Plasma Membrane
Endosome Membrane
Large Ribosomal Subunit
Cytosolic Large Ribosomal Subunit
Cytosolic Ribosome
Endocytic Vesicle Membrane
Vesicle
Extracellular Exosome
Ribonucleoprotein Complex
Plasma Membrane
Membrane
Apical Part Of Cell
Activin Receptor Complex
BMP Receptor Complex
Molecular Function
Structural Constituent Of Ribosome
Protein Binding
Protein Tag Activity
Ubiquitin Protein Ligase Binding
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta Receptor Activity, Type I
Protein Binding
ATP Binding
Kinase Activity
Activin Receptor Activity, Type I
Transferase Activity
Peptide Hormone Binding
Growth Factor Binding
Protein Homodimerization Activity
Cadherin Binding
SMAD Binding
Metal Ion Binding
Activin Binding
Transforming Growth Factor Beta Binding
BMP Receptor Activity
Protein Tyrosine Kinase Binding
Biological Process
Cytoplasmic Translation
Translation
Protein Ubiquitination
Response To Insecticide
Modification-dependent Protein Catabolic Process
Protein Modification Process
Branching Involved In Blood Vessel Morphogenesis
Osteoblast Differentiation
In Utero Embryonic Development
Gastrulation With Mouth Forming Second
Mesoderm Formation
Neural Crest Cell Migration
Acute Inflammatory Response
Embryonic Heart Tube Morphogenesis
Outflow Tract Septum Morphogenesis
Atrioventricular Valve Morphogenesis
Mitral Valve Morphogenesis
Endocardial Cushion Formation
Endocardial Cushion Fusion
Atrial Septum Primum Morphogenesis
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Germ Cell Development
Determination Of Left/right Symmetry
Gastrulation
Mesoderm Development
Heart Development
Dorsal/ventral Pattern Formation
Negative Regulation Of Signal Transduction
Cell Differentiation
Regulation Of Ossification
Positive Regulation Of Cell Migration
Positive Regulation Of Bone Mineralization
BMP Signaling Pathway
Activin Receptor Signaling Pathway
Negative Regulation Of Activin Receptor Signaling Pathway
Endothelial Cell Differentiation
Positive Regulation Of Cell Differentiation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Smooth Muscle Cell Differentiation
Positive Regulation Of Multicellular Organismal Process
Pharyngeal System Development
Positive Regulation Of SMAD Protein Signal Transduction
Ventricular Septum Morphogenesis
Epithelial Tube Morphogenesis
Cardiac Muscle Cell Fate Commitment
Endocardial Cushion Cell Fate Commitment
Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition
Cellular Response To Growth Factor Stimulus
Cellular Response To BMP Stimulus
Circulatory System Development
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Determination Of Dorsal Identity
Regulation Of Multicellular Organismal Development
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Activation of NF-kappaB in B cells
ISG15 antiviral mechanism
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
ER-Phagosome pathway
Downregulation of ERBB4 signaling
Spry regulation of FGF signaling
Downregulation of ERBB2:ERBB3 signaling
L13a-mediated translational silencing of Ceruloplasmin expression
Peptide chain elongation
Budding and maturation of HIV virion
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
DDX58/IFIH1-mediated induction of interferon-alpha/beta
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Membrane binding and targetting of GAG proteins
Assembly Of The HIV Virion
APC-Cdc20 mediated degradation of Nek2A
SRP-dependent cotranslational protein targeting to membrane
SRP-dependent cotranslational protein targeting to membrane
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
EGFR downregulation
SCF(Skp2)-mediated degradation of p27/p21
Viral mRNA Translation
Degradation of beta-catenin by the destruction complex
TCF dependent signaling in response to WNT
Downstream TCR signaling
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
Regulation of activated PAK-2p34 by proteasome mediated degradation
NOTCH1 Intracellular Domain Regulates Transcription
Activated NOTCH1 Transmits Signal to the Nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Selenocysteine synthesis
Separation of Sister Chromatids
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Regulation of PLK1 Activity at G2/M Transition
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Stimuli-sensing channels
Constitutive Signaling by NOTCH1 HD Domain Mutants
FCERI mediated NF-kB activation
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
Regulation of innate immune responses to cytosolic DNA
Glycogen synthesis
Autodegradation of the E3 ubiquitin ligase COP1
Deactivation of the beta-catenin transactivating complex
Myoclonic epilepsy of Lafora
ABC-family proteins mediated transport
TAK1-dependent IKK and NF-kappa-B activation
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Regulation of FZD by ubiquitination
PINK1-PRKN Mediated Mitophagy
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Hedgehog 'on' state
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
Negative regulation of MAPK pathway
Regulation of necroptotic cell death
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAP3K8 (TPL2)-dependent MAPK1/3 activation
HDR through Homologous Recombination (HRR)
MAPK6/MAPK4 signaling
UCH proteinases
UCH proteinases
Josephin domain DUBs
Ub-specific processing proteases
Ovarian tumor domain proteases
Metalloprotease DUBs
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Processing of DNA double-strand break ends
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Fanconi Anemia Pathway
Major pathway of rRNA processing in the nucleolus and cytosol
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
Regulation of TP53 Activity through Methylation
Negative regulation of MET activity
Assembly of the pre-replicative complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Cyclin D associated events in G1
G2/M Checkpoints
Stabilization of p53
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Formation of a pool of free 40S subunits
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Termination
Ubiquitin-dependent degradation of Cyclin D
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Downregulation of ERBB2 signaling
VLDLR internalisation and degradation
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
InlB-mediated entry of Listeria monocytogenes into host cell
InlB-mediated entry of Listeria monocytogenes into host cell
InlA-mediated entry of Listeria monocytogenes into host cells
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN localization
Regulation of PTEN stability and activity
Neddylation
ER Quality Control Compartment (ERQC)
Regulation of expression of SLITs and ROBOs
Regulation of expression of SLITs and ROBOs
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH3 Activation and Transmission of Signal to the Nucleus
TICAM1-dependent activation of IRF3/IRF7
TICAM1,TRAF6-dependent induction of TAK1 complex
Interleukin-1 signaling
Peroxisomal protein import
Peroxisomal protein import
Interferon alpha/beta signaling
Regulation of signaling by CBL
Endosomal Sorting Complex Required For Transport (ESCRT)
Iron uptake and transport
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
Negative regulation of NOTCH4 signaling
Chaperone Mediated Autophagy
Late endosomal microautophagy
Response of EIF2AK4 (GCN2) to amino acid deficiency
Prevention of phagosomal-lysosomal fusion
Modulation by Mtb of host immune system
Alpha-protein kinase 1 signaling pathway
Aggrephagy
Aggrephagy
RAS processing
Pexophagy
Signaling by CSF1 (M-CSF) in myeloid cells
Maturation of protein E
SARS-CoV-1 activates/modulates innate immune responses
Maturation of protein E
Inactivation of CSF3 (G-CSF) signaling
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Negative regulation of FLT3
FLT3 signaling by CBL mutants
Regulation of BACH1 activity
Signaling by ALK fusions and activated point mutants
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
KEAP1-NFE2L2 pathway
Regulation of NF-kappa B signaling
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Degradation of CDH1
Amyloid fiber formation
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
Antigen processing: Ubiquitination & Proteasome degradation
Evasion by RSV of host interferon responses
Regulation of pyruvate metabolism
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
SPOP-mediated proteasomal degradation of PD-L1(CD274)
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
PD-L1(CD274) glycosylation and translocation to plasma membrane
Degradation of CRY and PER proteins
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
ATP
Dorsomorphin
Fostamatinib
Diseases
Fibrodysplasia ossificans progressiva (FOP)
GWAS
A body shape index (
34021172
)
Severe gingival inflammation (
28459102
)
Waist circumference adjusted for body mass index (
34021172
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
44 interacting genes:
ACVR1
ARRDC3
BMPR1B
DAZAP2
DESI1
DNAJB2
EPN2
EPN3
FAM168A
FILNC1
FNDC3B
FSHR
GRB2
HERC3
HGS
KHDRBS1
LAPTM5
LITAF
MAPK6
MTURN
NCK1
PLEKHB2
PLSCR4
POLI
RABGEF1
RAD23A
RNF11
SEC23B
SLC2A4
SMAD1
SMAD2
SMAD4
SMURF1
SNCA
SQSTM1
TAX1BP1
TGFBR1
TSG101
UBQLN1
UBQLN2
USP46
USP7
VPS28
WBP2
70 interacting genes:
AP2B1
BAMBI
BMP2
BMP6
BMP7
BMPR1A
BMPR2
CDK14
CHN1
CREBBP
CRIPTO
DCAF6
DUSP13B
ENG
FANCL
FBXO30
FBXO7
FCHO1
FGD6
FKBP4
FNTA
GDF2
GDF5
IGSF1
IKBKB
INHBA
INHBB
INHBC
KLHL35
NEK8
NKIRAS1
NRAS
NUAK2
OTUB1
PAK1
PLEK
PLEKHB1
PLEKHJ1
RAB17
RAB25
RAB33B
RAB3B
RAB6B
RAP2A
RASD2
RASL12
RHEBL1
RHOD
RHOJ
RPS27A
RRAS2
RXRA
SKIC8
SMAD1
SMAD5
SMAD9
SOCS6
STIP1
STX8
TGFBR1
TGFBR2
THRB
TTC17
TTC27
UBA52
UBE2E3
UBXN1
USP39
VDR
VEPH1
Entrez ID
7311
90
HPRD ID
08931
00021
Ensembl ID
ENSG00000221983
ENSG00000115170
Uniprot IDs
P62987
Q3MIH3
Q7Z4P3
D3DPA4
Q04771
PDB IDs
2LJ5
2MBH
2MJB
2MUR
2N3U
2N3V
2N3W
2NBD
2NBE
2RSU
4HJK
4JIO
4P4H
4PIG
4PIH
4PIJ
4RF0
4RF1
4S1Z
4UG0
4V6X
4XKL
5AJ0
5GO7
5GO8
5GOB
5GOC
5GOD
5GOG
5GOH
5GOI
5GOJ
5GOK
5HPK
5HPL
5HPS
5HPT
5J26
5J8P
5JBV
5JBY
5LKS
5T2C
6IP5
6IP6
6IP8
6LQM
6OLE
6OLF
6OLG
6OLI
6OLZ
6OM0
6OM7
6QZP
6XA1
6Y0G
6Y2L
6Y57
6Y6X
6Z6L
6Z6M
6Z6N
6ZM7
6ZME
6ZMI
6ZMO
7AY1
7BHP
7F5S
7M3Q
7OWC
7UN3
7WFC
7XD0
7XNX
7XNY
7ZF1
7ZH3
7ZH4
8A3D
8IFD
8IFE
8IK6
8IKM
8IKT
8IKV
8IPJ
8JDJ
8JDK
8JDL
8JDM
8K2C
8OHD
8OJ0
8OJ5
8OJ8
8QFD
8QOI
8QYX
8UKB
8XSX
8XSY
8XSZ
8Y0W
8Y0X
8YOO
8YOP
9C3H
9G8M
9GMO
3H9R
3MTF
3OOM
3Q4U
4BGG
4C02
4DYM
5OXG
5OY6
5S75
5S76
5S77
5S78
5S79
5S7A
5S7B
5S7C
5S7D
5S7E
5S7F
5S7G
5S7H
5S7I
5S7J
5S7K
5S7L
5S7M
5S7N
5S7O
5S7P
5S7Q
5S7R
5S7S
5S7T
5S7U
5S7V
5S7W
5S7X
5S7Y
5S7Z
5S80
5S81
5S82
5S83
5S84
5S85
5S86
5S87
5S88
5S89
5S8A
5S8B
5S9K
6ACR
6EIX
6GI6
6GIN
6GIP
6I1S
6JUX
6SRH
6SZM
6T6D
6T8N
6TN8
6UNQ
6UNR
6UNS
6Z36
6ZGC
7A21
7C3G
7NNS
7YRU
8C7W
8C7Z
8POD
8R7G
8UWR
9D8E
9D8F
9D8Z
Enriched GO Terms of Interacting Partners
?
Endosome
I-SMAD Binding
SMAD Binding
Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Establishment Of Protein Localization To Vacuole
Regulation Of Cell Communication
Regulation Of Signaling
Negative Regulation Of Signal Transduction
Regulation Of Protein Catabolic Process
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Positive Regulation Of Metabolic Process
Protein Localization To Vacuole
Transforming Growth Factor Beta Receptor Activity, Type I
Ubiquitin Binding
Protein-containing Complex
Positive Regulation Of Macromolecule Metabolic Process
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
SMAD Protein Complex
Regulation Of Protein Ubiquitination
Heteromeric SMAD Protein Complex
Ubiquitin Protein Ligase Binding
Cytoplasm
Activin Receptor Signaling Pathway
Positive Regulation Of Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Regulation Of Primary Metabolic Process
Modification-dependent Protein Catabolic Process
BMP Signaling Pathway
Polyubiquitin Modification-dependent Protein Binding
Regulation Of Post-translational Protein Modification
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Vacuolar Transport
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Protein Sequestering Activity
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Proteolysis
Proteolysis
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Homomeric SMAD Protein Complex
Positive Regulation Of Ubiquitin-dependent Endocytosis
Regulation Of Metabolic Process
Proteolysis Involved In Protein Catabolic Process
Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Protein Targeting To Vacuole
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Positive Regulation Of SMAD Protein Signal Transduction
Regulation Of SMAD Protein Signal Transduction
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
BMP Signaling Pathway
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
GTP Binding
Signal Transduction
Regulation Of Signal Transduction
Activin Receptor Signaling Pathway
Cellular Response To BMP Stimulus
GTPase Activity
Regulation Of Intracellular Signal Transduction
Osteoblast Differentiation
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Bone Mineralization
Response To Growth Factor
Cartilage Development
Positive Regulation Of Biomineral Tissue Development
Regulation Of Cell Communication
Regulation Of Signaling
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Ossification
Positive Regulation Of Cartilage Development
Growth Factor Activity
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Cartilage Development
Positive Regulation Of Osteoblast Differentiation
GDP Binding
Regulation Of Bone Mineralization
Nucleotide Binding
Anatomical Structure Morphogenesis
Positive Regulation Of Signal Transduction
SMAD Protein Signal Transduction
Enzyme Activator Complex
Intracellular Signal Transduction
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Heart Development
Regulation Of Osteoblast Differentiation
Positive Regulation Of Epithelial To Mesenchymal Transition
Tricuspid Valve Morphogenesis
Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Intracellular Signaling Cassette
Morphogenesis Of A Branching Structure
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Cell Differentiation
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